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Chemical Structure| 518064-25-0 Chemical Structure| 518064-25-0

Structure of 518064-25-0

Chemical Structure| 518064-25-0

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Product Details of [ 518064-25-0 ]

CAS No. :518064-25-0
Formula : C7H9N3S
M.W : 167.23
SMILES Code : NCC1=CN2C(SC(C)=C2)=N1
MDL No. :MFCD11506342

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Application In Synthesis of [ 518064-25-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 518064-25-0 ]

[ 518064-25-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 47375-34-8 ]
  • [ 518064-25-0 ]
  • [ 891845-36-6 ]
YieldReaction ConditionsOperation in experiment
77% With HATU; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20℃; for 3h; To 1-(2-methylimidazo[2,1 -jb][1 ,3]thiazol-6-yl)methanamine 3 (1.43 g, 8.51 mmol) and Fmoc~Try(t-Bu)-OH (4.30 g, 9.36 mmol) dissolved in DMF (60 mL), o-(7-azabenxotriazol- 1-yl)-N,N,N',N'-tetramethyluronium (3.56 g, 9.36 mmol) and diisopropylethyl amine (2.96 mL, 17.02 mmol) were added. After the reaction mixture was stirred at room temperature for 3 hrs under argon, the resulting mixture was concentrated and redissolved with ethyl acetate (100 mL) and water (100 mL). The aqueous phase was extracted with ethyl acetate (75 mLx2). The combined organic phase was washed with water (100 mLx3), brine (100 mL), dried over MgSC>4 and concentrated. The residue was purified by combiflash (100 g column, eluting with 10% ethyl acetate/ methylene chloride, 95% ethyl acetate/ methylene chloride) and repurified by combiflash (100 g column, eluting with 5% MeOH/ CH2CI2) to afford α(1 ,1-dimethylethyl)-/V-[(9H-fluoren-9-ylmethyl)oxy] carbonyl}- Λ/-[(2-methylimidazo[2,1 -ib][1 ,3]thiazol-6-yl)methyl]-L-tyrosinamide (9) (4.48 g, 86%) LC/MS (ESI) 609.4 [M+H]+ Rt 2.14 min
 

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