Home Cart Sign in  
Chemical Structure| 521969-44-8 Chemical Structure| 521969-44-8

Structure of 521969-44-8

Chemical Structure| 521969-44-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 521969-44-8 ]

CAS No. :521969-44-8
Formula : C10H8ClN3O
M.W : 221.64
SMILES Code : O=C1N(C)C(Cl)=NC(C2=CC=NC=C2)=C1

Safety of [ 521969-44-8 ]

Application In Synthesis of [ 521969-44-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 521969-44-8 ]

[ 521969-44-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 521969-44-8 ]
  • [ 5234-86-6 ]
  • 2-(1,3,4,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-2-yl)-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% With triethylamine; In N,N-dimethyl-formamide; for 6.0h; 2-(l,3,4,6.7,llb-Hexahvdro-pyrazino[2,l-a1isoalphauinolin-2-vl)'3-methvl-6-pvridin-4-yl-3 H-pvrimidin-4-one; 2-Chloro-3-methyl-6-pyridin-4-yl"3H-pyrimidin-4-one (332 mg, 1.5 mmol) was added to the solution of 1,3,4,6,7, llb"hexahydro-2H-pyrazino[2,l-a]isoquinoline (292 mg, 1.55 mmol), triethylamine (0.223 ml, 1.6 mmol) in N,N-dimethylformamide (8 ml) and the mixture was stirred for 6 hours and stood overnight ice -water. After addition180 <n="182"/>of ice-water the solution was partitioned between water and ethyl acetate, and the organic layer was washed with brine and dried with magnesium sulfate. The solvents were removed under reduced pressure and purification by silica gel column chromatography (eluent,' dichloromethane / methanol = 95/5) afforded title compound (530 mg, 95%). Treatment with 4N hydrogen chloride in ethyl acetate yielded corresponding hydrogen chloride salt (495 mg).
  • 2
  • [ 521969-44-8 ]
  • [ 52385-79-2 ]
  • 2-(3-(3-chlorophenyl)piperazin-1-yl)-3-methyl-6-(4-pyridyl)-3H-pyrimidin-4-one [ No CAS ]
 

Historical Records

Technical Information

Categories