630-580-1088 sales@ambeed.com
Structure Search

List Search MOL Search Structure Search

0
Chemistry
Asymmetric Synthesis >>Chiral Building BlocksChiral Catalysts, Chiral Ligands and Chiral ReagentsChiral Resolution ReagentsBoronic acids/esters >>Aliphatic BoronsAromatic BoronsOther BoronsOxaborolesCatalysis Chemistry >>Achiral Crown LigandsC-H ActivationCarbon-Donor LigandsChiral Carbon LigandsChiral Crown LigandsChiral Olefin LigandsCross-CouplingCross-Coupling Using Transition Metal CatalystsDACH or Trost LigandsChemical Biology >>Conjugation Chemistry
GlycoscienceLinkers and CrosslinkersNucleic Acid ChemistryPEGylationPeptide ChemistryPhotolabile Protecting GroupHeterocyclic Building Blocks >>AcridinesAliphatic HeterocyclesAromatic HeterocyclesAzetidinesBenzimidazolesBenzisoxazolesBenzodioxansBenzofuransBenzothiazolesInorganic reagents >>Inorganic ReagentOrganic Building Blocks >>Acid AnhydridesAcyl Chlorides
AlcoholsAldehydesAliphatic Chain HydrocarbonsAliphatic Cyclic HydrocarbonsAlkenesAlkylsAlkynesOrganometallic Reagents >>Grignard ReagentsOrganoarsenicOrganobismuthOrganoboronOrganogermaniumOrganolithiumOrganomercuryOrganosiliconOrganotinSpecialty Synthesis >>Enzyme-Mediated SynthesisFluorous SynthesisIonic Liquids
Solid Supported SynthesisStains and Dyes >>Acid DyesAzoic DyesBasic DyesDirect DyesDisperse DyesDye IntermediatesMordant DyesOil DyesOther Stains and DyesSynthetic Reagents >>Acids and BasesC-C Bond FormationC-X Bond Formation (Halogen)C-X Bond Formation (Non-Halogen)Chelation and Complexation CompoundsCondensation AgentsCouplingDehydrating ReagentsFluorination Reagent
Pharmaceutical Intermediates
Analgesics >>BenzhydrocodoneBicifadineCapsaicinCelecoxibDebio-0827DexamethasoneElagolix SodiumEsketamine HydrochlorideIbuprofen SodiumAnesthetics >>CiprofolEsketamine HydrochlorideFospropofol Fospropofol DisodiumLevobupivacaine RemimazolamRemimazolam BesilateRemimazolam BesylateRopivacaineAnti-Addiction Agents >>Kakonein
Lofexidine HydrochlorideVarenicline Anti-inflammatory Agents >>ApremilastAsunaprevirATB-346 RelatedBalsalazide BaricitinibBencycloquidium BromideBudesonideCefiderocol Sulfate TosylateCeftaroline Fosamil AcetateAntibacterials >>AFN-1252 RelatedAlatrofloxacin Bedaquiline FumarateBesifloxacin BrilacidinCaspofungin AcetateCefiderocol Sulfate TosylateCefilavancinCeftaroline Fosamil
Anticonvulsants >>BrivaracetamCannabidiolEscitalopram OxalateEslicarbazepine Acetate RelatedFosphenytoinGabapentin EnacarbilJNJ-10234094LacosamideLevetiracetam RelatedAntidementia Agents >>Azeliragon RelatedDavunetideDonepezil HydrochlorideDonepezil RelatedEnsaculinFlorbetaben Flortaucipir F 18Flutemetamol IdalopirdineAntidepressants >>4-Chlorokynurenine
AgomelatineAgomelatine RelatedAllopregnanolone RelatedAmibegronAmitifadineAripiprazole RelatedBasimglurantBefloxatoneAntiemetics >>AprepitantAprepitant RelatedDolasetron RelatedDolasetron Mesylate HydrateFosaprepitant DimeglumineFosaprepitant RelatedOlanzapinePalonosetron RelatedPalonosetron HydrochlorideAntifungals >>Anidulafungin RelatedCabotegravirMore >>
Inhibitors/Agonists
ADC >>ADC AntibodyADC LinkerADC Linker with PayloadADC ToxinAntibody-Drug Conjugates (ADCs)Drug-Linker Conjugates for ADCAngiogenesis >>ALKBcr-AblBTKEGFRFAKFGFRFLT3HER2HIFAnti-infection >>3CLproAntibacterialAntibioticAntifungal
AntiparasiticAntiprotozoalAntiviralArenavirusBVDVApoptosis >>Apoptosis InducerBcl-2Bcl-6BRKc-Mycc-RETC/EBPCARDCaspaseAutophagy >>Atg4ATG4BATTECsAUTACsAutophagyBeclin1
FKBPLC3LRRK2Biochemical Reagent >>Cell Cycle >>AntifolateAPCAurora KinaseBUBCasein KinaseCdc25CDKChkCRISPR/Cas9Cytoskeleton >>ActinArp2/3 ComplexCYTHCytoplasmic DyneinDynaminFAKMore >>
Material Science
Aggregation-Induced Emission >>Other AIE BlocksTetraphenylethylene SeriesCOFs Linkers >>Aldehyde COFs LinkersAlkynyl COFs LinkersAmine COFs LinkersBoric COFs LinkersCyano COFs LinkersMultifunctional COFs linkersOther COFs linkersTriptycene SeriesElectronic Materials >>Battery MaterialsDye-Sensitized Solar Cell (DSSC) MaterialsElectronic MaterialLiquid Crystal (LC) MaterialsMolecular ConductorsOrganic Light-Emitting Diode (OLED) MaterialsOrganic Solar Cell (OPV) MaterialsOrganic Transistor (OFET) MaterialsPerovskite Solar Cell (PSC) MaterialsMagnetic Materials >>Magnetic Ionic LiquidsMagnetic MaterialMagnetic Metal Complexes
Organic Radicals Material Chemical Compounds >>Ligands for Functional Metal ComplexesLiquid Crystal (LC) Building BlocksPhthalocyanine Building BlocksPolymer and Macromolecule Semiconductor Building BlocksSmall Molecule Semiconductor Building BlocksSolubility Enhancing Reagents Supramolecular Host Materials MOF Ligands >>Carboxylic Acid MOF LigandsCarboxylic Acid Nitrogen-Containing Mixed MOF LigandsNitrogen-Containing MOF LigandsOther MOF LigandsNanomaterials >>Carbon NanomaterialsCeramic MembranesDendrimersGold NanoparticlesIron Oxide NanoparticlesMaterials by ApplicationMesoporous MaterialsMetals and Metal AlloysNano Minerals: NanoclaysOLED Materials >>Dopant
HostHTMOLED IntermediatesOther OLED related materialsOptical Materials >>Coumarin DyesCyanine and Squarylium DyesDCM DyesDipyrromethene DyesFluorescence MaterialsFluorescent ProbesHeat and Pressure Sensitive DyesNear-Infrared (NIR) DyesOrganic Non-Linear Optical (NLO) MaterialsOrganic Pigments >>Organic PigmentOther Materials >>Mateial OtherPolymer Science >>MonomersPolymer AdditivesPolymerization ReagentsPolymersResins
Contact Us
Home Cart 0 Sign in  
Chemistry
Organic Building Blocks
Aryls
1,2,4,5-Tetrafluoro-3-methylbenzene
Chemistry
Organic Building Blocks
Aryls
Fluorinated Building Blocks Benzene Compounds

[ CAS No. 5230-78-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 5230-78-4
Chemical Structure| 5230-78-4
Structure of 5230-78-4 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 5230-78-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 5230-78-4 ]

SDS Specification
Alternatived Products of [ 5230-78-4 ]

Product Details of [ 5230-78-4 ]

CAS No. :5230-78-4 MDL No. :MFCD00000313
Formula : C7H4F4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 164.10 Pubchem ID :-
Synonyms :

Safety of [ 5230-78-4 ]

Signal Word:Danger Class:3
Precautionary Statements:P261-P280-P305+P351+P338 UN#:1993
Hazard Statements:H225-H302-H312-H319-H332-H335 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 5230-78-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5230-78-4 ]

[ 5230-78-4 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 5230-78-4 ]
  • [ 53001-73-3 ]
YieldReaction ConditionsOperation in experiment
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane 4 EXAMPLE 4 EXAMPLE 4 This example illustrates the preparation of 2,3,5,6-tetrafluorobenzyl bromide. A mixture of 2,3,5,6-tetrafluorotoluene (1.7 g), N-bromosuccinimide (1.9 g), dry carbon tetrachloride (10 ml) and benzoyl peroxide (0.01 g) was heated at the reflux temperature for 20 hours, cooled to the ambient temperature (ca.25° C.) filtered and the filtrate diluted with diethyl ether. The ethereal solution was washed with water, dried over anhydrous magnesium sulphate and concentrated by evaporation of the solvents to yield 2,3,5,6-tetrafluorobenzyl bromide as a mobile colourless oil.
Reference： [1]Current Patent Assignee: ASTRAZENECA PLC - US4370346, 1983, A
  • 2
  • [ 24673-56-1 ]
  • [ 5230-78-4 ]
  • [ 1263757-26-1 ]
Reference： [1]Journal of Organic Chemistry,2011,vol. 76,p. 882 - 893
  • 3
  • [ 83-54-5 ]
  • [ 5230-78-4 ]
  • [ 1358531-55-1 ]
YieldReaction ConditionsOperation in experiment
55% With diisopropylsulfide; palladium diacetate; silver carbonate In 1,4-dioxane at 140℃; Inert atmosphere; regioselective reaction;
Reference： [1]Chen, Fei; Feng, Zhang; He, Chun-Yang; Wang, Hao-Yang; Guo, Yin-Long; Zhang, Xingang [Organic Letters, 2012, vol. 14, # 4, p. 1176 - 1179]
  • 4
  • [ 50-00-0 ]
  • [ 5230-78-4 ]
  • [ 79538-03-7 ]
Reference： [1]Journal of Organic Chemistry,2015,vol. 80,p. 10874 - 10882
  • 5
  • [ 917-54-4 ]
  • potassium perfluorophenyltrifluoroborate [ No CAS ]
  • [ 363-72-4 ]
  • [ 21622-19-5 ]
  • [ 5230-78-4 ]
  • potassium 4-methyltetrafluorophenyltrifluoroborate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: methyllithium; potassium perfluorophenyltrifluoroborate In 1,2-dimethoxyethane; diethyl ether for 1h; Inert atmosphere; Heating; Stage #2: With potassium fluoride In 1,2-dimethoxyethane; diethyl ether; water for 8h; Inert atmosphere; 3.3. K[C6F5BF3] (128 mg, 0.46 mmol) in DME (5 mL) was reacted with 0.92 M MeLi inether (2 mL, 1.8 mmol) at 60-62 °C for 1 h. Suspension was cooled to 25 °C. Thesupernatant contained 4 (0.02 mmol), and several unknown compounds. After stirringof suspension with saturated aqueous solution of KF (10 mL) for 8 h the quantity of 4increased to 0.14 mmol and resonances of pentafluorobenzene (0.01 mmol) and2,3,4,5-tetrafluorotoluene (0.01 mmol) appeared besides unknown products (19FNMR).
Reference： [1]Shabalin, Anton Yu.; Adonin, Nicolay Yu.; Bardin, Vadim V. [Beilstein Journal of Organic Chemistry, 2017, vol. 13, p. 703 - 713]
  • 6
  • [ 3857-83-8 ]
  • [ 5230-78-4 ]
  • 2-(4'-methyl-2',3',5',6'-tetrafluorophenyl)naphthalene [ No CAS ]
YieldReaction ConditionsOperation in experiment
98.5% Stage #1: 2,3,5,6-tetrafluorotoluene With isopropylmagnesium chloride In tetrahydrofuran at 20℃; for 12h; Stage #2: With 18-crown-6 ether In 1,4-dioxane; 1,2-dimethoxyethane at 20℃; for 0.5h; Stage #3: 2-naphthyl triflate With bis(1,5-cyclooctadiene)nickel (0); bis[2-(di(2-naphthyl)phosphino)phenyl]ether In tetrahydrofuran; 1,4-dioxane at 40℃; for 6h; 16 2,3,5,6-tetrafluoro-1,1'-biphenyl 1,In the absence of anaerobic conditions,360 mg (2.4 mmol) of 1,2,4,5-tetrafluorobenzene was dissolved in 1 mL of tetrahydrofuran,Then, 1 mL of a 2 mol / L solution of isopropylmagnesium chloride in tetrahydrofuran was added,The reaction was stirred at room temperature for 12 hours,To the reaction solution was added 3 mL of 1,4-dioxane,0.6 mL of ethylene glycol dimethyl ether and 26.4 mg (0.10 mmol) of 18-crown ether-6,Stir for 30 minutes at room temperature.2, in the anhydrous anaerobic conditions,To 0.4 mL of tetrahydrofuran and 0.6 mL of 1,4-dioxane was added 20.6 g(0.08 mmol)Bis (1,5-cyclooctadiene) nickel,77 mg (0.1 mmol) of bis (2-bis (3,5-dimethyl-4-methoxyphenyl)phosphine)Phenyl ether,Stir for 30 minutes at room temperature.3, in the anhydrous anaerobic conditions,The reaction solution obtained in Step 1 and Step 2 was mixed,And 224 mg (1.0 mmol) of 2-methyl-5-iodothiophene was added,Stirring at room temperature for 6 hours,TLC detection reaction is complete,Add 0.5 mL of methanol for 10 min,After the reaction is quenched completely,The reaction solution was washed with 0.1 mol / L hydrochloric acid,And extracted with ethyl acetate,The ethyl acetate extract was dried over anhydrous sodium sulfate,Evaporated under reduced pressure,And then separated by silica gel column chromatography,To give the product 2-methyl-5- (2 ', 3', 5 ', 6'-tetrafluorophenyl) thiophene,Its yield was 91%.In step 1 of Example 1, 2.4 mmol of 1,2,4,5-tetrafluorobenzene was equimolar3-methyl-1,2,4,5-tetrafluorobenzene; in step 2,Bis (2-bis (3,5-dimethyl-4-methoxyphenyl) phosphine) phenylene ether was equimolarBis (2-bis (2-naphthyl) phosphine) phenyl ether;In step 3,2-methyl-5-iodothiophene was replaced with equimolar 2-naphthyl trifluoromethanesulfonate,The reaction temperature was raised to 40 ° C,The other steps were the same as in Example 1,To give 2- (4'-methyl-2 ', 3', 5 ', 6'-tetrafluorophenyl) naphthalene in a yield of 98.5%
98% With bis(1,5-cyclooctadiene)nickel (0); 18-crown-6 ether; 2-[bis((3,5-dimethyl-4-methoxyphenyl)phosphino)phenyl]ether; isopropylmagnesium chloride In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane at 40℃; for 2h;
Reference： [1]Current Patent Assignee: SHAANXI NORMAL UNIVERSITY - CN106187656, 2016, A Location in patent: Paragraph 0042-0044; 0052-0055; 0104-0107
[2]Wang, Junya; Meng, Ge; Xie, Kun; Li, Liting; Sun, Huaming; Huang, Zhiyan [ACS Catalysis, 2017, vol. 7, # 11, p. 7421 - 7430]
  • 7
  • [ 771-56-2 ]
  • [ 21622-19-5 ]
  • [ 5230-78-4 ]
  • 2,4,5,6-tetrafluorotoluene [ No CAS ]
YieldReaction ConditionsOperation in experiment
1: 65% 2: 9% 3: 4% With H2SiEt2; tetrabutylammonium triphenyldifluorosilicate In tetrahydrofuran; benzene-d6 at 60℃; for 40h; Inert atmosphere; Sealed tube;
Reference： [1]Kikushima, Kotaro; Grellier, Mary; Ohashi, Masato; Ogoshi, Sensuke [Angewandte Chemie - International Edition, 2017, vol. 56, # 51, p. 16191 - 16196][Angew. Chem., 2017, vol. 129, p. 16409 - 16414,6]
  • 8
  • [ 5230-78-4 ]
  • [ 79538-03-7 ]
Reference： [1]Patent: WO2018/218896,2018,A1

Tags: 5230-78-4 synthesis path| 5230-78-4 SDS| 5230-78-4 COA| 5230-78-4 purity| 5230-78-4 application| 5230-78-4 NMR| 5230-78-4 COA| 5230-78-4 structure

Same Skeleton Products
Related Products
Categories
Chemistry
Organic Building Blocks
Aryls
Chemistry
Organic Building Blocks
Fluorinated Building Blocks
Chemistry
Organic Building Blocks
Benzene Compounds
Historical Records