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Chemical Structure| 5275-07-0 Chemical Structure| 5275-07-0

Structure of 5275-07-0

Chemical Structure| 5275-07-0

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Product Details of [ 5275-07-0 ]

CAS No. :5275-07-0
Formula : C14H12N2
M.W : 208.26
SMILES Code : C1(CC2=CC=NC=C2)=CNC3=C1C=CC=C3
MDL No. :MFCD11915925

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5275-07-0 ]

[ 5275-07-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5275-07-0 ]
  • [ 3515-49-9 ]
YieldReaction ConditionsOperation in experiment
73% 3-(Pyridin-4-ylmethyl)-1H-indole (5.00 g, 24.0 mmol) and acetic acid (25 mL) were added to platinum(IV) oxide (1.00 g, 4.40 mmol, Johnson Matthey) in a 250 mL stainless steel pressure bottle and stirred for about 2 hr under about 30 psi hydrogen at ambient temperature. The mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was dissolved with EtOAc and then washed with saturated aqueous Na2CO3. The organic layer became turbid. A small amount of MeOH was added to form a clear solution. The organic layer was washed with 2 N aqueous NaOH and brine, dried over MgSO4, filtered, and concentrated under reduced pressure. The resulting solid was triturated with Et2O and then dried to give 3-(piperidin-4-ylmethyl)-1H-indole (4.35 g, 73% yield): LC/MS (Table 1, Method a) Rt=1.51 min; MS m/z: 215.12 (M+H)+.
 

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