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Chemical Structure| 53084-60-9 Chemical Structure| 53084-60-9

Structure of 53084-60-9

Chemical Structure| 53084-60-9

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Product Details of [ 53084-60-9 ]

CAS No. :53084-60-9
Formula : C9H17NO2
M.W : 171.24
SMILES Code : CCOC(=O)C1CCCC(N)C1
MDL No. :MFCD17283787

Safety of [ 53084-60-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 53084-60-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 53084-60-9 ]

[ 53084-60-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 53084-60-9 ]
  • [ 3177-24-0 ]
  • (1R,3S)-ethyl 3-((4-chloro-5-cyanopyrimidin-2-yl)amino)cyclohexane-carboxylate [ No CAS ]
  • C14H17ClN4O [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20℃; for 1h; Preparation of Compound 1-4Synthetic Scheme 14(a) iPr2NEt, THF; (b) 5-Trifluoromethyl-l -(p-tolylsulfonyl)-3-(4,4,5,5-tetramethyl- 1 ,3,2- dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine (64), Pd(Ph3P)4, 2M Na2C03, CH3CN, 120 °C; (c) LiOH, THF, H20, 130 °CFormation of (IR, 3S)-ethyl 3-((4-chloro-5-cyanopyrimidin-2-yI)amino)cyclohexane- carboxylate (63)To a solution of <strong>[3177-24-0]2,4-dichloropyrimidine-5-carbonitrile</strong> (0.56 g, 3.23 mmol) and ( \\R, 35)- ethyl 3-aminocyclohexanecarboxylate, 56, (0.60 g) in THF (50 mL) was added N,N- diisopropylethylamine ( 1 .40 mL, 8.07 mmol) in THF (l OmL). The reaction mixture was stirred at room temperature for 1 hour. The mixture was concentrated to dryness then dissolved in dichloromethane and washed with I N HC1. The product was absorbed onto silica-gel and purified via silica gel chromatography (0-20percent EtOAc/hexanes gradient) to afford 195 mg of the less polar (faster moving) product along with 542 mg of the more polar (slower moving) product, which was determined to be the desired product, 63.
 

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