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Chemical Structure| 53233-90-2 Chemical Structure| 53233-90-2

Structure of 53233-90-2

Chemical Structure| 53233-90-2

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Product Details of [ 53233-90-2 ]

CAS No. :53233-90-2
Formula : C6H7NO2S
M.W : 157.19
SMILES Code : O=C(C1=CN=C(C)S1)OC
MDL No. :MFCD14635883
InChI Key :WJPVCUYKYLWTPC-UHFFFAOYSA-N
Pubchem ID :21427465

Safety of [ 53233-90-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 53233-90-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 53233-90-2 ]

[ 53233-90-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 53233-90-2 ]
  • [ 56012-38-5 ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran; methanol; ethyl acetate; STEP A 2-methyl-5-hydroxymethyl-thiazole 2.54 g of lithium aluminum hydride were added at 20-25 C. under a nitrogen atmosphere to a solution of 10.5 g of methyl 2-methyl-5-thiazolecarboxylate in 105 ml of anhydrous tetrahydrofuran and the mixture was refluxed for one hour and then cooled. Addition of ethyl acetate and then methanol destroyed excess hydride and the mixture was filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica gel to obtain 7.6 g of product which was crystallized from isopropyl ether to obtain 5.28 g of 2-methyl-5-hydroxymethyl-thiazole melting at 50 C.
 

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