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[ CAS No. 533-17-5 ]

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Chemical Structure| 533-17-5
Chemical Structure| 533-17-5
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Product Details of [ 533-17-5 ]

CAS No. :533-17-5 MDL No. :MFCD00045169
Formula : C8H8ClNO Boiling Point : 340°C at 760 mmHg
Linear Structure Formula :ClC6H4NHCOCH3 InChI Key :N/A
M.W :169.61 g/mol Pubchem ID :10777
Synonyms :

Safety of [ 533-17-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 UN#:N/A
Hazard Statements:H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 533-17-5 ]

  • Upstream synthesis route of [ 533-17-5 ]
  • Downstream synthetic route of [ 533-17-5 ]

[ 533-17-5 ] Synthesis Path-Upstream   1~11

  • 1
  • [ 533-17-5 ]
  • [ 61-70-1 ]
Reference: [1] Journal of the American Chemical Society, 1985, vol. 107, # 2, p. 435 - 443
[2] Journal of the American Chemical Society, 1985, vol. 107, # 2, p. 435 - 443
  • 2
  • [ 533-17-5 ]
  • [ 1910-85-6 ]
Reference: [1] Journal of the Indian Chemical Society, 1957, vol. 34, p. 413
  • 3
  • [ 533-17-5 ]
  • [ 53297-68-0 ]
Reference: [1] Journal of Medicinal Chemistry, 2003, vol. 46, # 11, p. 2187 - 2196
  • 4
  • [ 533-17-5 ]
  • [ 6283-25-6 ]
  • [ 121-87-9 ]
Reference: [1] Justus Liebigs Annalen der Chemie, 1876, vol. 182, p. 108[2] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1877, vol. 9, p. 110
  • 5
  • [ 533-17-5 ]
  • [ 769-11-9 ]
Reference: [1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1976, p. 1183 - 1190
[2] Journal fuer Praktische Chemie (Leipzig), 1921, vol. <2>102, p. 184
  • 6
  • [ 533-17-5 ]
  • [ 3460-23-9 ]
YieldReaction ConditionsOperation in experiment
90% With hydrogen bromide; Selectfluor In water at 20℃; for 1 h; General procedure: 1a as example: To a stirred suspension of N-(p-tolyl)acetamide 1a (75 mg, 0.5 mmol) and Selectfluor (213 mg, 0.6 mmol) in water (3.0 mL) was added HBr (40percent aqueous, 0.08 mL, 0.55 mmol), and the mixture was stirred for 5 min at room temperature. After 1a was consumed, as indicated by TLC, the reaction mixture was quenched with saturated aqueous Na2S2O3 (2.0 mL) and water (20.0 mL), and extracted with CH2Cl2 (10.0 mL) three times. The residue obtained after evaporation of the solvent was purified by column chromatography on silica gel (petroleum ether–ethyl acetate = 6:1, v/v) to afford N-(2-bromo-4-methylphenyl)acetamide 2a as a white solid (108 mg, 95percent yield).
Reference: [1] Chemistry - A European Journal, 2017, vol. 23, # 5, p. 1044 - 1047
[2] Tetrahedron Letters, 2016, vol. 57, # 48, p. 5390 - 5394
[3] Journal of Chemical Research, Synopses, 1997, # 11, p. 432 - 433
[4] European Journal of Organic Chemistry, 2018, vol. 2018, # 43, p. 5972 - 5979
[5] Gazzetta Chimica Italiana, 1908, vol. 38 II, p. 22
  • 7
  • [ 533-17-5 ]
  • [ 10035-10-6 ]
  • [ 7697-37-2 ]
  • [ 3460-23-9 ]
Reference: [1] Gazzetta Chimica Italiana, 1908, vol. 38 II, p. 22
  • 8
  • [ 507-20-0 ]
  • [ 533-17-5 ]
  • [ 42265-67-8 ]
Reference: [1] Journal of Organic Chemistry, 1996, vol. 61, # 17, p. 5804 - 5812
  • 9
  • [ 533-17-5 ]
  • [ 56762-32-4 ]
Reference: [1] Photochemical and Photobiological Sciences, 2016, vol. 15, # 1, p. 105 - 116
  • 10
  • [ 533-17-5 ]
  • [ 6953-83-9 ]
  • [ 56762-32-4 ]
Reference: [1] Photochemical and Photobiological Sciences, 2016, vol. 15, # 1, p. 105 - 116
  • 11
  • [ 533-17-5 ]
  • [ 6953-83-9 ]
  • [ 56762-32-4 ]
  • [ 95-51-2 ]
Reference: [1] Photochemical and Photobiological Sciences, 2016, vol. 15, # 1, p. 105 - 116
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