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Chemical Structure| 5373-87-5 Chemical Structure| 5373-87-5

Structure of 5373-87-5

Chemical Structure| 5373-87-5

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Product Details of [ 5373-87-5 ]

CAS No. :5373-87-5
Formula : C8H10N2O2
M.W : 166.18
SMILES Code : N/C(C1=CC=C(OC)C=C1)=N\O
MDL No. :MFCD05664434

Safety of [ 5373-87-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H228-H315-H319
Precautionary Statements:P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
Class:4.1
UN#:1325
Packing Group:

Application In Synthesis of [ 5373-87-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5373-87-5 ]

[ 5373-87-5 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 19887-32-2 ]
  • [ 5373-87-5 ]
  • ethyl {(S)-1-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-2-phenylethyl}carbamate [ No CAS ]
  • 2
  • [ 2905-65-9 ]
  • [ 5373-87-5 ]
  • [ 690986-21-1 ]
YieldReaction ConditionsOperation in experiment
91% With sodium hydroxide; In dimethyl sulfoxide; at 20℃; for 3.25h; The title compound was prepared according to the published protocol5. To a solution of 4-methoxybenzamidoxime (332 mg, 2 mmol) and methyl 3-.chlorobenzoate (554 mg, 3 mmol)in DMSO (3 mL) powdered NaOH (120 mg, 3.0 mmol) was rapidly added. The solid precipitate was formed after 15 mm stirring. The heterogeneous mixture was stirred at room temperature for 3 h. The reaction mixture was diluted with cold water (60 mL). The resulting precipitate was filtered off, washed with water (3x30 mL) and air dried to provide the product sery562 as a white crystalline solid (520 mg, 91%).TLC (hexane:EtOAc, 7/1 vlv): RF = 0.50.1H NMR (400 MHz, DMSO-d6)ö = 8.16 (t, J= 1.6 Hz, 1H), 8.13 (d, J= 7.8 Hz, 1H), 8.03(d, J8.8 Hz, 2H), 7.80 (m, 1H), 7.69 (t, J = 7.2 Hz, 1H), 7.14 (d, J = 8.8 Hz, 2H), 3.85 (5, 3H).13C NMR (100.6 MHz, DMSO-d6) ö = 173.9, 168.0, 161.9, 134.1, 133.1, 131.6, 128.8, 127.4,126.6, 125.3, 118.2, 114.7, 55.4.LC MS (RP18-100A, gradient 0% CH3CN/100% H20 - 100% CH3CN in 50 mm), RT 46.8 mm and mass 287.06 (100%), 288.95 (35%) ([M+H]),M.p. 130 C.
  • 3
  • [ 5373-87-5 ]
  • [ 19887-32-2 ]
  • C20H23N3O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: In a sealed tube in amicrowave reactor, 0.8 mmol of L-N-protected amino acid(1-5) and DCC (0.96 mmol, 0.199 g) were dissolved in acetone(1.0 mL) and the mixture was magnetically stirred forapproximately 40 minutes to form the reactive intermediate. Then, 0.8 mmol of aryl amidoxime (a-e) was added, and themixture was homogenized. The acetone was removed inroute evaporator without heating, and H2O (1.0 mL) wasadded to the mixture, which was subjected to microwaveirradiation at 100W power, temperature of 115C, during15 min. Soon after, the reaction crude was dissolved in ethylacetate and washed with water. The organic phase was driedover magnesium sulfate, and the solvent was removed undervacuum. The residue was purified by column chromatographyon silica gel (hexane-ethyl acetate, 7 : 3) to afford pureproducts (1-5a-e). Detailed experimental procedures, 1Hand 13C NMR spectra for all compounds, are available in thesupporting information, ESI (available here).
  • 4
  • [ 5373-87-5 ]
  • [ 19887-32-2 ]
  • ethyl {(S)-1-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-2-phenylethyl}carbamate [ No CAS ]
 

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