[ CAS No. 54049-24-0 ] {[proInfo.proName]}

Name: 54049-24-0|Methyl 7-bromoheptanoate|98%
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Quality Control of [ 54049-24-0 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 54049-24-0 ]

Product Details of [ 54049-24-0 ]

CAS No. :	54049-24-0	MDL No. :	MFCD02258672
Formula :	C₈H₁₅BrO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BXRLUWIDTDLHQE-UHFFFAOYSA-N
M.W :	223.11	Pubchem ID :	554086
Synonyms :

Calculated chemistry of [ 54049-24-0 ]

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.88
Num. rotatable bonds :	7
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	49.72
TPSA :	26.3 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.6 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.46
Log Po/w (XLOGP3) :	2.9
Log Po/w (WLOGP) :	2.5
Log Po/w (MLOGP) :	2.43
Log Po/w (SILICOS-IT) :	2.55
Consensus Log Po/w :	2.57

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.59
Solubility :	0.576 mg/ml ; 0.00258 mol/l
Class :	Soluble
Log S (Ali) :	-3.11
Solubility :	0.172 mg/ml ; 0.000771 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.25
Solubility :	0.127 mg/ml ; 0.000569 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.33

Safety of [ 54049-24-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 54049-24-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 54049-24-0 ]
Downstream synthetic route of [ 54049-24-0 ]

[ 54049-24-0 ] Synthesis Path-Upstream 1~8

1
[ 54049-24-0 ]
[ 10160-24-4 ]

Reference： [1] Chemistry Letters, 1977, p. 959 - 962
[2] Journal of Organic Chemistry, 1969, vol. 34, # 12, p. 3952 - 3958

2
[ 67-56-1 ]
[ 30515-28-7 ]
[ 54049-24-0 ]

Reference： [1] Journal of Natural Products, 2016, vol. 79, # 1, p. 244 - 247
[2] Tetrahedron Letters, 2012, vol. 53, # 24, p. 3082 - 3085
[3] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 22, p. 6981 - 6995
[4] Inorganic Chemistry, 2017, vol. 56, # 18, p. 11050 - 11058

3
[ 67-56-1 ]
[ 20965-27-9 ]
[ 54049-24-0 ]

Reference： [1] European Journal of Organic Chemistry, 2000, # 21, p. 3575 - 3579

4
[ 629-30-1 ]
[ 54049-24-0 ]

Reference： [1] Bulletin of the Chemical Society of Japan, 1986, vol. 59, # 11, p. 3535 - 3539
[2] Journal of Natural Products, 2016, vol. 79, # 1, p. 244 - 247

5
[ 50816-19-8 ]
[ 54049-24-0 ]

Reference： [1] Tetrahedron Letters, 2012, vol. 53, # 24, p. 3082 - 3085

6
[ 10160-24-4 ]
[ 54049-24-0 ]

Reference： [1] Journal of Natural Products, 2016, vol. 79, # 1, p. 244 - 247

7
[ 2041-15-8 ]
[ 54049-24-0 ]
[ 88784-99-0 ]

Reference： [1] Helvetica Chimica Acta, 1983, vol. 66, # 7, p. 2294 - 2307

8
[ 186581-53-3 ]
[ 30515-28-7 ]
[ 54049-24-0 ]

Reference： [1] Bulletin of the Chemical Society of Japan, 1986, vol. 59, # 11, p. 3535 - 3539

[ 54049-24-0 ] Synthesis Path-Downstream 1~19

1
[ 54049-24-0 ]
[ 7770-45-8 ]
C₁₉H₂₂O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In N,N-dimethyl-formamide; at 60℃; for 24h;	To a solution of hydroxybenzaldehyde (25mmol) in DMF (50mL) was added potassiumcarbonate (6.9g, 50mmol) followed by alkylbromide (37.5mmol). The solution wasstirred at 60 C for 24h. The solution was diluted with ethyl acetate (500mL) and washedwith 0.2M potassium carbonate (4x50mL). The organic layer was dried over sodium sulfate and evaporated under vacuum to provide the crude product.To a solution of above crude aldehyde in acetonitrile (25mL) was added successively aqueous hydrogen peroxide (3mL, 25mmol) and a solution of NaH2PO4*4H2O (0.8g, 5.8mmol) in 10mL of water. Solid sodium chlorite (tech. grade,80% purity, 4.0g, 35mmol) was added slowly cooling with an ice bath. The reaction isexothermic! After the addition was complete, the ice bath was removed and the reaction mixture was stirred for 12h at room temperature. The reaction was quenched by slow addition of a solution of sodium bisulfite (8g in 10mL water) cooling with an ice-bath.The quench is exothermic! After evaporation of the organic solvent, the desired productwas crystallized from the solution and was collected by filtration. The crude product was washed with water and dried in vacuo to give the monoacid mono ester.The hydrazides and hydroxamic acids are prepared following the procedure described for reagents B4 and B5.

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 2601 - 2605

2
[ 67-56-1 ]
[ 30515-28-7 ]
[ 54049-24-0 ]

Yield	Reaction Conditions	Operation in experiment
91%	With n-butyllithium; In hexane; at -78 - 20℃; for 12h;	Add anhydrous ether (30 mL) to a 100 mL three-necked flask. 7-Bromoheptanoic acid (31.4 g, 150 mmol), followed by slow dropwise addition of methanol (9.6 g, 12.3 ml, 300 mmol).After the completion of the dropwise addition, the reaction system was stirred at room temperature for 12 h.Cool the mixture to -78 C, n-Butyllithium (4 mL, 2.5 mol/L in hexane, 10 mmol) was slowly added dropwise, and after the addition was completed, the mixture was filtered. The solvent was removed under reduced pressure to give a crude product. Finally, it is purified by silica gel column chromatography to obtain a colorless liquid. Methyl <strong>[30515-28-7]7-bromoheptanoate</strong> (30.5 g, 91% yield).
	With thionyl chloride; at 20℃; for 2h;	General procedure: SOCl2 (15.0 mmol) was added dropwise into a solution of bromo carboxylic acid (10.0 mmol) in methanol (30 mL). The mixture was stirred at room temperature for 2 h. The solution was concentrated to give the crude product, which was used directly for the next step.

Reference： [1]Journal of Natural Products,2016,vol. 79,p. 244 - 247
[2]Patent: CN104892366,2016,B .Location in patent: Paragraph 0013; 0057-0058
[3]Tetrahedron Letters,2012,vol. 53,p. 3082 - 3085
[4]Bioorganic and Medicinal Chemistry,2013,vol. 21,p. 6981 - 6995
[5]Inorganic Chemistry,2017,vol. 56,p. 11050 - 11058

3
[ 40429-04-7 ]
[ 54049-24-0 ]
[ 1432509-07-3 ]

Yield	Reaction Conditions	Operation in experiment
38%	With sodium hydride; In N,N-dimethyl-formamide; at 60℃; for 6h;	2,2-dimethyl-2,3-dihydro-1H-carbazol-4(9H)-on [formula 1-2] (0.1 g, 0.46 mmol) was dissolved in DMF (10 mL), then ethyl 7-bromoheptanoate (0.109 g, 0.46 mmol) and NaH (0.014 g, 0.59 mmol) were added and stirred at 60 C. for 6 hours. After the completion of the reaction, DMF was distilled out under reduced pressure, the reaction mixture was extracted with ethyl acetate and saturated NaHCO3 aqueous solution, the organic layer was washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Residue was purified by column chromatography (SiO2; hexane/ethylacetate, 4/1) to yield the title compound (0.065 g, 38%).

Reference： [1]Patent: US2014/315889,2014,A1 .Location in patent: Paragraph 0172-0174

4
[ 54049-24-0 ]
[ 1197159-91-3 ]
C₂₅H₃₆N₆O₄ [ No CAS ]

Reference： [1]Bulletin of the Korean Chemical Society,2016,vol. 37,p. 42 - 47

5
[ 54049-24-0 ]
[ 123948-87-8 ]
methyl (S)-7-((10-((dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)heptanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
24%	With potassium carbonate; In N,N-dimethyl-formamide; for 24h;Heating;	<strong>[123948-87-8](S)-10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione</strong> 1 (9.0 g, 22.9 mmol) was taken in DMF (100 mL) in a 500 mL round bottom flask. To it were added K2CO3 (6.3 g, 45.9 mmol) and methyl 7-bromoheptanoate 2 (6.1 g, 27.5 mmol). The reaction mixture was heated for 24h. The crude was purified by silica gel (100- 200 mesh) using 10% MeOH-DCM as eluent to afford 3 as a yellow solid (3.0 g, 24%).

Reference： [1]Patent: WO2016/203337,2016,A2 .Location in patent: Paragraph 00162; 00163

6
[ 54049-24-0 ]
[ 153707-56-3 ]
C₁₆H₂₄O₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate In N,N-dimethyl-formamide at 85℃; for 12h; Inert atmosphere;

Reference： [1]Liu, Yu-Wei; Shia, Kak-Shan; Wu, Chien-Huang; Liu, Kuan-Liang; Yeh, Yu-Cheng; Lo, Chen-Fu; Chen, Chiung-Tong; Chen, Yun-Yu; Yeh, Teng-Kuang; Chen, Wei-Han; Jan, Jiing-Jyh; Huang, Yu-Chen; Huang, Chen-Lung; Fang, Ming-Yu; Gray, Brian D.; Pak, Koon Y.; Hsu, Tsu-An; Huang, Kuan-Hsun; Tsou, Lun K. [Bioconjugate Chemistry, 2017, vol. 28, # 7, p. 1878 - 1892]

7
[ 571190-30-2 ]
[ 54049-24-0 ]
C₃₂H₄₃N₇O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	With potassium carbonate; In N,N-dimethyl-formamide; at 60℃; for 1h;Microwave irradiation;	A solution of palbociclib (50 mg, 0.112 mmol), methyl 7-bromoheptanoate (75 mg, 0.335 mmol)and K2C03 (46 mg, 0.335 mmol) in DMF (5 ml) was heated at 60 °C in a microwave reactorfor 1 h. After being cooled to RT, the reaction mixture was filtered and concentrated, and the resulting residue was purified by prep-HPLC to yield the title compound (40 mg, 60percent) as yellow solid. ?H NMR (600 MHz, CD3OD) oe 9.10 (s, 1H), 8.21 (dd, J= 9.6, 2.7 Hz, 1H), 7.98 (d, J 2.5 Hz, 1H), 7.59 (d, J 9.6 Hz, 1H), 5.99 (p, J= 8.8 Hz, 1H), 3.93 (s, 2H), 3.75 (s,2H), 3.65 (s, 3H), 3.38 ? 3.16 (m, 6H), 2.49 (s, 3H), 2.42 (s, 3H), 2.37 ?2.25 (m, 4H), 2.13 ?2.03 (m, 2H), 1.94 ? 1.86 (m, 2H), 1.85 ? 1.78 (m, 2H), 1.72 ? 1.59 (m, 4H), 1.47 ? 1.36 (m, 4H). HRMS (ESI-TOF) m/z: [M+Hj calculated for C32H44N704, 590.3449; found: 590.3446.

Reference： [1]Patent: WO2018/106870,2018,A1 .Location in patent: Page/Page column 85; 112

8
[ 54049-24-0 ]
[ 76115-06-5 ]
C₃₄H₃₄O₃ [ No CAS ]

Reference： [1]Chemistry - An Asian Journal,2019,vol. 14,p. 781 - 788

9
[ 75844-40-5 ]
[ 54049-24-0 ]
C₁₇H₂₂N₂O₃ [ No CAS ]

Reference： [1]Chemistry and biodiversity,2019,vol. 16

10
[ 19181-53-4 ]
[ 54049-24-0 ]
C₁₇H₂₂N₂O₃ [ No CAS ]

Reference： [1]Chemistry and biodiversity,2019,vol. 16

11
[ 16064-24-7 ]
[ 54049-24-0 ]
C₁₇H₂₂N₂O₄ [ No CAS ]

Reference： [1]Chemistry and biodiversity,2019,vol. 16

12
[ 54049-24-0 ]
[ 16499-56-2 ]
C₁₆H₁₉FN₂O₃ [ No CAS ]

Reference： [1]Chemistry and biodiversity,2019,vol. 16

13
[ 16064-14-5 ]
[ 54049-24-0 ]
C₁₆H₁₉ClN₂O₃ [ No CAS ]

Reference： [1]Chemistry and biodiversity,2019,vol. 16

14
[ 54049-24-0 ]
[ 20872-93-9 ]
C₁₆H₁₉N₃O₅ [ No CAS ]

Reference： [1]Chemistry and biodiversity,2019,vol. 16

15
[ 1769-24-0 ]
[ 54049-24-0 ]
C₁₇H₂₂N₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2-methyl-4-quinazolone With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 0.5h; Stage #2: With potassium iodide In N,N-dimethyl-formamide for 0.25h; Stage #3: methyl 7-bromoheptanoate In N,N-dimethyl-formamide at 60℃; for 3h;
	Stage #1: 2-methyl-4-quinazolone With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 0.5h; Stage #2: With potassium iodide In N,N-dimethyl-formamide for 0.25h; Stage #3: methyl 7-bromoheptanoate In N,N-dimethyl-formamide at 60℃; for 3h;	2 2. Synthesis of Compound 10 General procedure: Each mixture of 2-aminobenzoic acid (1a-c) (2 mmol) and acetic anhydride (2 mL) was heated to reflux (120 ° C.) until the reaction was complete (1-2 hours). Then ammonium acetate (308 mg, 4 mmol) was added. The reaction mixture was stirred again at 80 ° C. for 3 hours. At the end of the reaction, the resulting mixture was cooled and poured into ice cold water. The precipitate was filtered and dried to give 2-methylquinazolin-4 (3H) -one derivative 7 which was used in the next step without further purification. To each solution of DMF (3 mL) containing compound 8a-c (1 mmol) was added K 2 CO 3 (165.5 mg, 1.2 mmol). The resulting mixture was stirred for 30 min at 60 ° C., then KI (8.3 mg, 0.05 mmol) was added. After stirring for an additional 15 minutes, 0.5 ml solution of DMF containing methyl 7-bromoheptanoate was slowly added dropwise to the mixture. The reaction mixture was stirred again at 60 ° C. for 3 hours. The reaction mixture was then poured into ice cold water (10 mL). A precipitate was obtained, washed with water and dried to give a compound (of intermediate 9a-c above). Each ester intermediate 9a-c was dissolved in DMF and hydroxylamine hydrochloride (685 mg, 10 mmol) was added and then added dropwise to a solution of NaOH (400 mg in 1 mL water). The mixture was stirred for 30 min at -5 ° C. At the end of the reaction, the resulting mixture was poured into ice cold water, neutralized to pH-7 and slightly acidified by dropwise addition of 5% HCl solution to induce maximum precipitation. The precipitate was filtered off, dried and recrystallized in methanol to yield the title compound 10a-c.

Reference： [1]Hieu, Doan Thanh; Anh, Duong Tien; Hai, Pham-The; Thuan, Nguyen Thi; Huong, Le-Thi-Thu; Park, Eun Jae; Young Ji; Soon Kang, Jong; Phuong Dung, Phan Thi; Han, Sang-Bae; Nam, Nguyen-Hai [Chemistry and biodiversity, 2019, vol. 16, # 4]
[2]Current Patent Assignee: CHUNGBUK NATIONAL UNIVERSITY - KR2019/134180, 2019, A Location in patent: Paragraph 0144-0145

16
[ 18731-19-6 ]
[ 54049-24-0 ]
C₁₈H₂₄N₂O₃ [ No CAS ]

Reference： [1]Chemistry and biodiversity,2019,vol. 16

17
[ 7142-09-8 ]
[ 54049-24-0 ]
C₁₇H₂₁ClN₂O₃ [ No CAS ]

Reference： [1]Chemistry and biodiversity,2019,vol. 16

18
[ 30515-28-7 ]
[ 124-41-4 ]
[ 54049-24-0 ]

Yield	Reaction Conditions	Operation in experiment
91%	In diethyl ether; at 20℃; for 12h;	Anhydrous diethyl ether (30mL) and <strong>[30515-28-7]7-bromoheptanoic acid</strong> (31.4g, 150mmol) were added to a 100mL three-necked flask, and then slowly added dropwiseMethanol (9.6g, 12.3ml, 300mmol), after the dropwise addition, the reaction system was stirred at room temperature for 12h.The mixture was cooled to -78 C, and n-butyllithium (4mL, 2.5mol / L in hexane, 10mmol) was slowly added dropwise. After the addition was completed,The mixture was filtered and the solvent was removed under reduced pressure to obtain the crude product.Finally, it was purified by silica gel column chromatography to obtain colorless liquid methyl <strong>[30515-28-7]7-bromoheptanoate</strong> (30.5 g, 91% yield).

Reference： [1]Patent: CN104774138,2016,B .Location in patent: Paragraph 0013; 0061-0062

19
[ 844442-38-2 ]
[ 54049-24-0 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	With sodium carbonate; sodium iodide In acetonitrile at 80℃;

Reference： [1]Liu, Yulin; Wei, Yujiao; Wang, Xuan; Ma, Lan; Li, Xuechun; Sun, Yue; Wu, Yanjie; Zhang, Li; Wang, Jiefu; Li, Ming; Zhang, Kun; Wei, Mingming; Yang, Guang; Yang, Cheng [European Journal of Medicinal Chemistry, 2023, vol. 249]

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Ghs Precautionary Statements

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P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
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Code	Phrase
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P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 54049-24-0 ] {[proInfo.proName]}

Quality Control of [ 54049-24-0 ]

Related Doc. of [ 54049-24-0 ]

Product Details of [ 54049-24-0 ]

Calculated chemistry of [ 54049-24-0 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 54049-24-0 ]

Application In Synthesis of [ 54049-24-0 ]

[ 54049-24-0 ] Synthesis Path-Upstream 1~8

[ 54049-24-0 ] Synthesis Path-Downstream 1~19

Related Functional Groups of [ 54049-24-0 ]

Aliphatic Chain Hydrocarbons

Bromides

Esters

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

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[ 54049-24-0 ]