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Chemical Structure| 54305-90-7 Chemical Structure| 54305-90-7

Structure of 54305-90-7

Chemical Structure| 54305-90-7

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Product Details of [ 54305-90-7 ]

CAS No. :54305-90-7
Formula : C6H12Cl2
M.W : 155.07
SMILES Code : ClC(C)CCCCCl
MDL No. :MFCD19232022

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Application In Synthesis of [ 54305-90-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54305-90-7 ]

[ 54305-90-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13781-53-8 ]
  • [ 54305-90-7 ]
  • (+/-) cis 2-methyl-1-(3-thienyl)cyclohexane carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium chloride; potassium carbonate; In n-heptane; water; N,N-dimethyl-formamide; EXAMPLE 18 (+-) cis 2-Methyl-1-(3-thienyl)cyclohexane Carbonitrile 43 g of potash in 160 ml of DMF is placed in a 500 ml three-necked flask. The reaction medium is cooled down to -10 C. and a solution of 17.6 g of 3-thienylacetonitrile in 40 ml of DMF is added dropwise over 30 minutes while maintaining the temperature at -10 C. Agitation is then carried out for 20 minutes. A solution of 24.7 g of 1,5-dichlorohexane in 40 ml of DMF is then added over 30 minutes at -10 C. Agitation is then carried out for 15 minutes, and the reaction medium is allowed to return to 20-25 C. over 1.5 hours. Agitation is then carried out for 18 hours at 25 C., then for 4 hours at 60 C. The temperature is allowed to return to 20-25 C. after driving off the DMF under vacuum, followed by taking up in 1 l of water. Extraction is carried out using 600 ml then 400 ml of heptane. The organic phase is washed with 400 ml of water then 400 ml of a solution of sodium chloride. The solution obtained is dried over magnesium sulphate, filtered and concentrated. After distillation under vacuum, 15.2 g of a colourless oil is obtained corresponding to the desired product (Bp0.08 =114-120 C.). NMR-13 C (CDCl3): 17.9; 23.5; 25.2; 34.7; 39.1; 40.7; 47.8; 121.2; 121.3; 124.7; 126.6; 142.1.
 

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