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[ CAS No. 5448-43-1 ]

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Chemical Structure| 5448-43-1
Chemical Structure| 5448-43-1
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Product Details of [ 5448-43-1 ]

CAS No. :5448-43-1 MDL No. :MFCD00047594
Formula : C8H5ClN2 Boiling Point : 276.9°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :164.59 g/mol Pubchem ID :-
Synonyms :

Safety of [ 5448-43-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P305+P351+P338 UN#:N/A
Hazard Statements:H302-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 5448-43-1 ]

  • Upstream synthesis route of [ 5448-43-1 ]
  • Downstream synthetic route of [ 5448-43-1 ]

[ 5448-43-1 ] Synthesis Path-Upstream   1~12

  • 1
  • [ 6935-29-1 ]
  • [ 91-19-0 ]
  • [ 1448-87-9 ]
  • [ 5448-43-1 ]
  • [ 7483-33-2 ]
Reference: [1] Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804
  • 2
  • [ 6935-29-1 ]
  • [ 1448-87-9 ]
  • [ 5448-43-1 ]
  • [ 62163-09-1 ]
  • [ 1196-57-2 ]
Reference: [1] Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804
  • 3
  • [ 6935-29-1 ]
  • [ 1448-87-9 ]
  • [ 5448-43-1 ]
Reference: [1] Bulletin des Societes Chimiques Belges, 1986, vol. 95, # 8, p. 663 - 670
  • 4
  • [ 5448-43-1 ]
  • [ 6298-37-9 ]
Reference: [1] Organic Letters, 2015, vol. 17, # 23, p. 5934 - 5937
[2] Angewandte Chemie - International Edition, 2015, vol. 54, # 12, p. 3773 - 3777[3] Angew. Chem., 2015, vol. 127, # 12, p. 3844 - 3848,5
[4] Angewandte Chemie - International Edition, 2015, vol. 54, # 12, p. 3768 - 3772[5] Angew. Chem., 2015, vol. 127, # 12, p. 3839 - 3843,5
[6] Organic Letters, 2014, vol. 16, # 17, p. 4388 - 4391
  • 5
  • [ 5448-43-1 ]
  • [ 7467-91-6 ]
Reference: [1] Journal of the American Chemical Society, 2016, vol. 138, # 41, p. 13493 - 13496
[2] Organic Letters, 2012, vol. 14, # 14, p. 3688 - 3691
[3] Journal of Organic Chemistry, 2018, vol. 83, # 17, p. 9850 - 9857
[4] Organic Letters, 2017, vol. 19, # 11, p. 2853 - 2856
  • 6
  • [ 6935-29-1 ]
  • [ 1448-87-9 ]
  • [ 5448-43-1 ]
  • [ 62163-09-1 ]
  • [ 1196-57-2 ]
Reference: [1] Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804
  • 7
  • [ 6935-29-1 ]
  • [ 7677-24-9 ]
  • [ 5448-43-1 ]
  • [ 62163-09-1 ]
  • [ 1196-57-2 ]
  • [ 7483-33-2 ]
Reference: [1] Tetrahedron, 1989, vol. 45, # 24, p. 7795 - 7804
  • 8
  • [ 5448-43-1 ]
  • [ 6639-79-8 ]
Reference: [1] Journal of Organic Chemistry, 2013, vol. 78, # 21, p. 11096 - 11101
  • 9
  • [ 5448-43-1 ]
  • [ 39267-11-3 ]
  • [ 6639-79-8 ]
Reference: [1] Journal of the Chemical Society, 1953, p. 2816,2819
  • 10
  • [ 5448-43-1 ]
  • [ 7722-84-1 ]
  • [ 64-19-7 ]
  • [ 39267-11-3 ]
  • [ 6639-79-8 ]
Reference: [1] Journal of the Chemical Society, 1953, p. 2816,2819
  • 11
  • [ 5448-43-1 ]
  • [ 64-18-6 ]
  • [ 7722-84-1 ]
  • [ 108-24-7 ]
  • [ 6639-80-1 ]
  • [ 6639-79-8 ]
Reference: [1] Journal of the Chemical Society, 1953, p. 2816,2819
  • 12
  • [ 5448-43-1 ]
  • [ 73183-34-3 ]
  • [ 1167418-13-4 ]
YieldReaction ConditionsOperation in experiment
75%
Stage #1: With tris-(dibenzylideneacetone)dipalladium(0); XPhos In tetrahydrofuran at 20℃; for 0.0833333 h; Inert atmosphere
Stage #2: at 70℃; for 5 h; Inert atmosphere
Under a nitrogen stream, 6-chloro-quinoxaline (5.15 g, 31.3 mmol), bi spinner cholate diborane (8.74 g, 34.4 mmol),in tetrahydrofuran (200 mL), tris (dibenzylideneacetone) dipalladium (287 mg, 0. 31 mmol), 2-dicyclohexylphosphino-2 ', 4', 6'-triisopropyl-biphenyl (597 mg, 1.25 mmol) was added to 300mL3 neck flask, and stirred at room temperature for 5 minutes. The solution to the potassium acetate (9.22g, 94.9mmol) was added, and the mixture was stirred for 5 hours at 70 ° C. Then, after cooling to room temperature, water was added to the reaction mixture and extracted. The organic layer was washed with saturated brine, and dried with anhydrous magnesium sulfate. Thereafter, the organic layer was concentrated by an evaporator. The resulting organic layer was concentrated The residue was purified by silica gel column chromatography (eluent = toluene / hexane), the desired product 2- (4,4,5,5-tetramethyl-1,3,2 dioxaborolan-2-yl) quinoxaline was obtained as a brown oil (yield 6.0 g, 75percent yield, LC 98.7percent purity). Compound identification was performed by H-NMR measurement
Reference: [1] Patent: JP2015/199681, 2015, A, . Location in patent: Paragraph 0105; 0106
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