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Chemical Structure| 545340-46-3 Chemical Structure| 545340-46-3

Structure of 545340-46-3

Chemical Structure| 545340-46-3

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Product Details of [ 545340-46-3 ]

CAS No. :545340-46-3
Formula : C15H13ClN2O
M.W : 272.73
SMILES Code : O=C(C1=CC=CN=C1Cl)N2CCCC3=C2C=CC=C3
MDL No. :MFCD03387231

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 545340-46-3 ]

[ 545340-46-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 545340-46-3 ]
  • [ 141483-15-0 ]
  • [ 1224639-52-4 ]
YieldReaction ConditionsOperation in experiment
67% With caesium carbonate;tetrakis(actonitrile)copper(I) hexafluorophosphate; In toluene; at 150℃; for 1h;Microwave irradiation; Example 144 (3,4-Dihydro-2H-quinolin-1-yl)-[2-(2-fluoro-5-trifluoromethyl-phenoxy)-pyridin-3-yl]-methanone To a solution of (2-chloro-pyridin-3-yl)-(3,4-dihydro-2H-quinolin-1-yl)-methanone (50 mg, 0.18 mmol, 1.0 equiv; Example 6, Step 1) and 2-fluoro-5-trifluoromethyl-phenol (42.1 mg, 0.23 mmol, 1.3 equiv; [CAS RN 141483-15-0]) in anhydrous toluene (0.5 mL) was added caesium carbonate (176 mg, 0.54 mmol, 3.0 equiv; [CAS RN 534-17-8]) and tetrakis(acetonitrile)copper(I) hexafluorophosphate (20.1 mg, 0.054 mmol, 0.3 equiv; [CAS RN 64443-05-6]). The reaction mixture was heated by microwave irradiation to 150 C. for 1 h. Purification by preparative HPLC on reversed phase (Xterra PrepMSC 18, 5 mum, 19*50 mm column equipped with a Gilson Liquid Handler 215 autosampler, two Rainin Dynamax SD-300 pumps, a Sedex ELSD 75 lightscatter and a Dionex UVD 340S UV detector) eluding with a gradient of acetonitrile/water provided 50 mg (67%) of the title compound as a light yellow solid. MS (ISP): 417.4 [M+H]+.
 

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