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Chemical Structure| 54537-48-3 Chemical Structure| 54537-48-3

Structure of 54537-48-3

Chemical Structure| 54537-48-3

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Product Details of [ 54537-48-3 ]

CAS No. :54537-48-3
Formula : C7H12BrNO
M.W : 206.08
SMILES Code : CC(Br)C(N1CCCC1)=O
MDL No. :MFCD13173089

Safety of [ 54537-48-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H335-H334-H314
Precautionary Statements:P260-P264-P270-P271-P280-P285-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P403+P233-P405-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 54537-48-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54537-48-3 ]

[ 54537-48-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 54537-48-3 ]
  • [ 65417-22-3 ]
  • methyl 2-methyl-1-(1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1H-indole-3-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
93% With caesium carbonate; In N,N-dimethyl-formamide; at 100℃; for 12h; Methyl 2-methyl-1-(1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1H-indole-3-carboxylate. To a round bottom flask charged with <strong>[65417-22-3]methyl 2-methyl-1H-indole-3-carboxylate</strong> (0.52 mmol, 0.1 g) in DMF (5 mL), was added 2-bromo-1-(pyrrolidin-1-yl)propan-1-one (0.52 mmol, 0.137 mg) and Cs2CO3 (1.05 mmol, 384 mg). The reaction was heated at 100 C for 12 h.The reaction was cooled, concentrated and the residue partitioned between water and DCM. The organic layer was separated, concentrated, then purified by silica gel chromatography (DCM/MeOH= 45:1) to provide methyl 2-methyl-1-(1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1H-indole-3-carboxylate (100 mg, 93%).
 

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