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CAS No. :	546-43-0
Formula :	C₁₅H₂₀O₂
M.W :	232.32
SMILES Code :	O=C(O[C@@]1([H])[C@]2([H])C=C3[C@@H](C)CCC[C@]3(C)C1)C2=C
Synonyms :	Alant camphor; Inula camphor; AI3-31147
MDL No. :	MFCD00046915

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H317
Precautionary Statements:	P261-P280

HL60	3.26 μM	72 h	Inhibited HL60 cell proliferation	PMC5034521
NRK-52E cells	10 μM	24 h	The combined treatment had little effect on normal NRK-52E cells.	PMC6643222
HEB human brain glial cells	289.8 μM (IC50)		Relatively lower cytotoxicity	PMC8843874
HS5 human bone marrow stromal cells	44.07 μM (IC50)		Relatively lower cytotoxicity	PMC8843874
LO2 human hepatocytes	128.6 μM (IC50)		Relatively lower cytotoxicity	PMC8843874
U2OS osteosarcoma cells	5.531 μM (IC50)	24h, 48h, 72h	Inhibited cell proliferation, reduced PCNA protein level	PMC8843874
MG63 osteosarcoma cells	6.963 μM (IC50)	24h, 48h, 72h	Inhibited cell proliferation, reduced PCNA protein level	PMC8843874
143B osteosarcoma cells	4.251 μM (IC50)	24h, 48h, 72h	Inhibited cell proliferation, reduced PCNA protein level	PMC8843874
HL-7702 cells	10 μM	24 h	The combined treatment had little effect on normal HL-7702 cells.	PMC6643222
HL60/ADR	3.28 μM	72 h	Inhibited HL60/ADR cell proliferation	PMC5034521
K562	2.75 μM	72 h	Inhibited K562 cell proliferation	PMC5034521
Normal hematopoietic cells	26.37 μM	72 h	Low toxicity to normal hematopoietic cells	PMC5034521
KG1a	2.75 μM	72 h	Inhibited KG1a cell proliferation	PMC5034521
THP-1	2.17 μM	72 h	Inhibited THP-1 cell proliferation	PMC5034521
K562/A02	2.73 μM	72 h	Inhibited K562/A02 cell proliferation	PMC5034521
SaoS2 osteosarcoma cells	0 μM, 4 μM, 6 μM, 8 μM, 10 μM	24h, 48h, 72h	Inhibited cell proliferation, reduced PCNA protein level	PMC8843874
SH-SY5Y cells	0, 1, 10, 25, 50 μM	48 h	Evaluate the effect of ATL on cell viability, IC50 value was 24.06 ± 2.38 μM.	PMC5508758
U118 cells	0, 1, 10, 25, 50 μM	48 h	Evaluate the effect of ATL on cell viability, IC50 value was 29.16 ± 2.84 μM.	PMC5508758
U251 cells	0, 10, 20 μM	24 h	Evaluate the effect of ATL on cell cycle and apoptosis, results showed ATL significantly increased the proportion of cells in G0/G1 phase and induced apoptosis.	PMC5508758
U87 cells	0, 10, 20 μM	24 h	Evaluate the effect of ATL on cell cycle and apoptosis, results showed ATL significantly increased the proportion of cells in G0/G1 phase and induced apoptosis.	PMC5508758
RKO cells	10 μM	24 h	Enhanced oxaliplatin-induced growth inhibition and apoptosis in RKO cells through significant accumulation of intracellular reactive oxygen species (ROS) and activation of JNK and p38 MAPK signaling pathways.	PMC6643222
HCT116 cells	10 μM	24 h	Enhanced oxaliplatin-induced growth inhibition and apoptosis in HCT116 cells through significant accumulation of intracellular reactive oxygen species (ROS) and activation of JNK and p38 MAPK signaling pathways.	PMC6643222
HUVEC cells	0.01-20 μM	48 h	Assess the toxicity of A@HAP NPs on normal cells, showing no significant toxicity to HUVEC cells at equivalent concentrations.	PMC11795048
CT26 cells	0.01-20 μM	48 h	Evaluate the in vitro anti-tumor efficacy of A@HAP NPs, showing dose-dependent cytotoxicity against CT26 cells, with stronger effects than HA-PTX or PTX alone.	PMC11795048
MCF-7 human breast cancer cells	10, 20, 30 µM	15 days	To evaluate the effect of Alantolactone on colony formation in MCF-7 cells. The results showed that Alantolactone significantly inhibited colony formation in a concentration-dependent manner.	PMC6108867
MCF-7 human breast cancer cells	10, 20, 30 µM	24 h	To evaluate the effect of Alantolactone on the migration of MCF-7 cells. The results showed that Alantolactone significantly inhibited cell migration in a dose- and time-dependent manner.	PMC6108867
MCF-7 human breast cancer cells	10, 20, 30 µM	24 h	To evaluate the effect of Alantolactone on apoptosis in MCF-7 cells. The results showed that Alantolactone significantly increased the percentage of apoptotic cells in a concentration-dependent manner.	PMC6108867
MCF-7 human breast cancer cells	5, 10, 20, 30, 40, 80 µM	24 and 48 h	To evaluate the inhibitory effect of Alantolactone on the proliferation of MCF-7 cells. The results showed that Alantolactone significantly reduced cell viability, with IC50 values of 35.45 µM at 24 h and 24.29 µM at 48 h.	PMC6108867
HK-2 cells	1, 2, 4 µM	24 h	To evaluate the effect of Alantolactone on TGF-β-stimulated expression of fibrotic factors in HK-2 cells. Results showed that Alantolactone inhibited TGF-β-stimulated expression of collagen type I and PAI-1 mRNA and protein.	PMC10850280
NRK-49F cells	1, 2, 4 µM	24 h	To evaluate the effect of Alantolactone on TGF-β-stimulated expression of fibrotic factors in NRK-49F cells. Results showed that Alantolactone dose-dependently inhibited TGF-β-stimulated expression of collagen type I, fibronectin, PAI-1, and α-SMA mRNAs.	PMC10850280
SCC9 cells	8 µM		Evaluate the effect of ALT on SCC9 cell ROS production, results showed ALT significantly increased ROS levels	PMC10193726
CAL27 cells	12 µM		Evaluate the effect of ALT on CAL27 cell ROS production, results showed ALT significantly increased ROS levels	PMC10193726
SCC9 cells	4 µM	24 h	Evaluate the effect of ALT on SCC9 cell viability, results showed ALT significantly reduced cell viability	PMC10193726
CAL27 cells	10 µM	24 h	Evaluate the effect of ALT on CAL27 cell viability, results showed ALT significantly reduced cell viability	PMC10193726

BALB/c nude mice	KG1a xenograft model	Oral	100 mg/kg	Every 3 days for 30 days	Suppressed tumor growth	PMC5034521
Female athymic mice	143B osteosarcoma xenograft model	Intra-gastric administration	5 mg/kg, 15 mg/kg, 25 mg/kg	Once every 2 days, for 21 days	Inhibited tumor growth and metastasis, reduced PCNA, Bcl-2, Vimentin, β-catenin and p-p38 protein levels	PMC8843874
BALB/c mice	IMQ-induced psoriasis model	Topical application	20 μM and 30 μM	Once daily for one week	To evaluate the therapeutic effect of CHALT on psoriasis symptoms. Results showed that CHALT significantly ameliorated IMQ-induced psoriasis symptoms, including reduced skin thickening, erythema, and scaling, and inhibited the activation of STAT3 signaling pathway.	PMC9091614
Nude mice (BALB/c nu/nu)	U87 xenograft model	Intraperitoneal injection	10, 20 mg/kg	Once daily for 15 days	Evaluate the inhibitory effect of ATL on tumor growth, results showed ATL significantly reduced tumor volume and weight.	PMC5508758
BALB/c nude mice	HCT116 xenograft model	Intraperitoneal injection	10 mg/kg	Once daily for 13 days	The combined treatment significantly inhibited the growth of HCT116 xenograft tumors by increasing the phosphorylation levels of JNK and p38 and decreasing Ki-67 expression.	PMC6643222
BALB/c mice	CT26 tumor model	Intravenous injection	2 mg/kg	Every 2 days for 14 days	Evaluate the in vivo anti-tumor efficacy of A@HAP NPs, showing significant tumor growth inhibition and enhanced immune cell infiltration and antigen presentation.	PMC11795048
C57BL/6 mice	Unilateral ureteral obstruction (UUO) model	Oral gavage	5 mg/kg	Once daily for 15 days (including 5 days of pretreatment)	To evaluate the effect of Alantolactone on UUO-induced renal fibrosis. Results showed that Alantolactone significantly alleviated UUO-induced renal tubulointerstitial damage and fibrosis and decreased collagen type I, fibronectin, and α-SMA expression.	PMC10850280

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CAS No.: 546-43-0

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CAS No.: 546-43-0

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Precautionary Statements-General

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	4.30mL 0.86mL 0.43mL	21.52mL 4.30mL 2.15mL	43.04mL 8.61mL 4.30mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed