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Chemical Structure| 54826-14-1 Chemical Structure| 54826-14-1

Structure of 54826-14-1

Chemical Structure| 54826-14-1

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Product Details of [ 54826-14-1 ]

CAS No. :54826-14-1
Formula : C8H6BrClO
M.W : 233.49
SMILES Code : CC(=O)C1=CC(Br)=C(Cl)C=C1
MDL No. :MFCD09832932
Boiling Point : No data available
InChI Key :WLNOSWNYESTEKE-UHFFFAOYSA-N
Pubchem ID :13347283

Safety of [ 54826-14-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 54826-14-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54826-14-1 ]

[ 54826-14-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 54826-14-1 ]
  • [ 42860-10-6 ]
  • 2
  • [ 54826-14-1 ]
  • [ 1231892-80-0 ]
  • 1-(3’-amino-6-chloro-2’-fluoro-[1,1‘-biphenyl]-3-yl)ethanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
75.05% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water; at 100.0℃; for 16h;Inert atmosphere; [0594] To a solution of compound 137 (600 mg, 2.58 mmol), compound 139 (732 mg, 3.12 mmol) and Na2CO3 (822 mg, 7.74 mmol) in dioxane/H2O (10 mL/3 mL) at room temperature under nitrogen, was added Pd(PPh3)4 (50 mg, 0.043 mmol). The reaction was stirred under nitrogen protection at 100 oC for 16 hrs. The resulting mixture was concentrated and the residue was purified by column chromatography on silica gel (eluted with Petroleum ether: Ethyl acetate =10: 1) to give the title compound (510 mg, 75.05% yield) as white solid. LC/MS (ESI) m/z: 264 (M+H) +.
  • 3
  • [ 54826-14-1 ]
  • [ 1231892-80-0 ]
  • (1R,3S,5R)-tert-butyl 3-((5'-acetyl-2'-chloro-2-fluoro-[1,1'-biphenyl]-3-yl)carbamoyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate [ No CAS ]
 

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