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Chemical Structure| 54995-51-6 Chemical Structure| 54995-51-6

Structure of 54995-51-6

Chemical Structure| 54995-51-6

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Product Details of [ 54995-51-6 ]

CAS No. :54995-51-6
Formula : C13H9ClN2O
M.W : 244.68
SMILES Code : NC1=CC=C(OC(C2=CC=C(Cl)C=C2)=N3)C3=C1
MDL No. :MFCD00477462

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Application In Synthesis of [ 54995-51-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54995-51-6 ]

[ 54995-51-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 54995-51-6 ]
  • [ 42860-10-6 ]
  • 3-bromo-4-chloro-N-(2-(4-chlorophenyl)benzo[d]oxazol-5-yl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% General procedure: Substituted benzoic acid or substituted phenylacetic acid 4(1 mmol) was added to a 50-mL round bottom flask and dissolvedwith DMF (20 mL), HOBt (1.5 mmol), EDCI (1.5 mmol), and TEA(1.5 mmol). Then, the solution was stirred at room temperature for10 min. DMF was added to dissolve 2-phenyl benzoxazole structure3, and then the solution was continuously stirred for 2e4 h. Thereaction was monitored by TLC and then stopped after completionwas indicated. The resultant solution was extracted with ethyl acetate(15 mL), washed twice with dilute hydrochloric acid (50 mL),and the organic phase was dried over anhydrous sodium sulfateand separated by silica gel column chromatography (petroleumether: ethyl acetate 2: 1). A yellow or white solid product 5 wasobtained (yield > 85%).
 

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