[ CAS No. 55270-27-4 ]

Name: 55270-27-4|4-Bromoisoquinolin-1-amine|97%
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Quality Control of [ 55270-27-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 55270-27-4 ]

SDS

Alternatived Products of [ 55270-27-4 ]

Product Details of [ 55270-27-4 ]

CAS No. :	55270-27-4	MDL No. :	MFCD05155261
Formula :	C₉H₇BrN₂	Boiling Point :	343.9°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	-
M.W :	223.07 g/mol	Pubchem ID :	311870
Synonyms :

Calculated chemistry of of [ 55270-27-4 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	10
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	1.0
Num. H-bond donors :	1.0
Molar Refractivity :	53.85
TPSA :	38.91 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.92 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.76
Log Po/w (XLOGP3) :	2.45
Log Po/w (WLOGP) :	2.59
Log Po/w (MLOGP) :	2.31
Log Po/w (SILICOS-IT) :	2.4
Consensus Log Po/w :	2.3

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.38
Solubility :	0.0923 mg/ml ; 0.000414 mol/l
Class :	Soluble
Log S (Ali) :	-2.91
Solubility :	0.274 mg/ml ; 0.00123 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.2
Solubility :	0.014 mg/ml ; 0.000063 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.65

Safety of [ 55270-27-4 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 55270-27-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 55270-27-4 ]
Downstream synthetic route of [ 55270-27-4 ]

[ 55270-27-4 ] Synthesis Path-Upstream 1~1

1
[ 1532-84-9 ]
[ 55270-27-4 ]

Reference： [1] Journal of Organic Chemistry, 2001, vol. 66, # 4, p. 1310 - 1315

[ 55270-27-4 ] Synthesis Path-Downstream 1~11

3
[ 1532-84-9 ]
[ 55270-27-4 ]

Reference： [1]Journal of Organic Chemistry,2001,vol. 66,p. 1310 - 1315

4
[ 75-11-6 ]
[ 55270-27-4 ]
5,11-dibromo-8H-diisoquinolino[1,2-a:2',1'-d][1,3,5]triazin-7-ium iodide [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2001,vol. 66,p. 1310 - 1315

5
[ 55270-27-4 ]
4-bromo-2-(4-bromo-1-imino-3-1H-isoquinolin-2-ylmethyl)-2H-isoquinolin-1-one [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2001,vol. 66,p. 1310 - 1315

6
[ 1257295-19-4 ]
[ 55270-27-4 ]
[ 1257296-13-1 ]

Yield	Reaction Conditions	Operation in experiment
	tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; at 140℃;Microwave irradiation; Inert atmosphere;	To intermediate 37 in a microwave vial is added 1.2 equivalents of an arylbromide, 1 equivalent of copper (I) iodide or copper thiophene-carboxylate, and 1,4-dioxaneas solvent. The reaction mixture is degassed under nitrogen for 5 minutes prior to addition of0.12 equivalents oftetrakis(triphenylphosphine)palladium(0). The reaction is heated in aCEM or Biotage microwave for 20-30 minutes at 140C. The crude reaction mixture isfiltered and periodically passed through a Biotage Isolute scx-2 basic spe cartridge beforebeing purified via normal or reverse phase chromatography to afford pure product 38.Substituents R2 and R3 may be R2 and R3 as defined, or protected forms or precursorsthereof.; 2-(l-((9-Methyl-6-morpholino-2-(tributylstannyl)-9H-purin-8- yl)methyl)piperidin-4-yl)propan-2-ol (0.1 g) was reacted with 4-bromoisoquinolin-l -amine via General Procedure G to afford 115 following reverse phase purification. MS (Ql) 517.3 (M)+,'H NMR (400 MHz, DMSO) delta 9.01 (d, IH), 8.56 (s, IH), 8.25 (d, IH), 7.67 (t, IH), 7.49 (t, IH), 7.07 (s, 2H), 4.23 (s, 4H), 4.02 (s, IH), 3.87 - 3.66 (m, 10H), 2.89 (d, 3H), 1.99 (t, 2H), 1.66 (d, 2H), 1.35 - 1.10 (m, 3H), 1.02 (s, 6H).

Reference： [1]Patent: WO2010/138589,2010,A1 .Location in patent: Page/Page column 250; 396

7
C₃₆H₅₅FN₂O₁₂ [ No CAS ]
[ 55270-27-4 ]
C₄₅H₆₁FN₄O₁₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; at 80℃; for 4h;Sonication; Inert atmosphere;	0.80 g (1.17 mmol) of compound 6 was dissolved in 20 mL of acetonitrile (degassed by ultrasonic)(Triphenylphosphine) palladium dichloride (41 mg, 0.058 mmol)22 mg (0.12 mmol) of cuprous iodide,Triethylamine 0.24 mL (1.75 mmol)And 0.91 g (4.09 mmol) of <strong>[55270-27-4]1-amino-4-bromoisoquinoline</strong>.The reaction system was replaced with argon for 5 times under argon,And stirred at 80 C for 4 h.After completion of the TLC monitoring reaction, distilled water (20 mL) was added to terminate the reaction,Extracted with ethyl acetate (40 mL)The upper organic phase was washed with saturated brine (20 mL)Steamed and concentrated to dry the solid.Column chromatography (100-200 mesh silica gel column,The mobile phase was V (dichloromethane): V (ethanol): V (aqueous ammonia) = 10: 0.2: 0.1)The 2'-O-acetyl-product 12 was isolated.2'-O-acetyl-product 12 was dissolved in 20 mL of methanol, refluxed at 65 C for 3 h,TLC monitoring reaction is complete, concentrated under reduced pressure,To give a dry product.Column chromatography (200-300 mesh silica gel column, mobile phase V (dichloromethane):V (ethanol): V (ammonia) = 10: 0.2:0.1) to give pure product 12 (29 mg, 0.035 mmol)Product 12 is 2-fluoro-3-O-decapramide-3-carbonyl-6-O-methylerythromycinA 9-O- [3- [4 '- (1'-amino) isoquinolinyl] -2-propynyl] oxime 11,12-cyclic carbonate,The yield is3.0%.

Reference： [1]Patent: CN106916194,2017,A .Location in patent: Paragraph 0149; 0150

8
2-chloro-2-(ethylthio)-1-[3-methyl-6-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]ethan-1-one [ No CAS ]
[ 55270-27-4 ]
6-bromo-3-(ethylsulfonyl)-2-[3-methyl-6-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]imidazo[2,1-a]isoquinoline [ No CAS ]

Reference： [1]Patent: JP2018/90578,2018,A

9
2-chloro-2-(ethylthio)-1-[3-methyl-6-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]ethan-1-one [ No CAS ]
[ 55270-27-4 ]
6-bromo-3-(ethylthio)-2-[3-methyl-6-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]imidazo[2,1-a]isoquinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
198 mg		2-chloro-2- (ethylthio) -1-[3-methyl-6- (trifluoromethyl) -3H-imidazo [4,5-b] pyridin-2-yl] ethan-1-one200 mg of acetonitrile and 3 ml of acetonitrile,At room temperature, 110 mg of <strong>[55270-27-4]4-bromoisoquinolin-1-amine</strong> was added.The mixture was stirred under heating reflux for 30 minutes.To the reaction mixture was added 50 mg of sodium hydrogencarbonate at room temperature.The reaction mixture was stirred under heating reflux for 4 hours.After completion of the reaction, 3 ml of water and 1 ml of 12 mol / L hydrochloric acid were added to the reaction mixture at room temperature.After filtering the precipitated solid, the obtained solid was washed with water,To obtain 198 mg of the objective compound as an orange solid.

Reference： [1]Patent: JP2018/90578,2018,A .Location in patent: Paragraph 0257

10
[ 55270-27-4 ]
[ 110-13-4 ]
ethyl 1-(2-chloro-4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
42.7%	With toluene-4-sulfonic acid; In toluene; for 36h;Reflux;	A solution of <strong>[55270-27-4]4-bromoisoquinolin-1-amine</strong> (5.5 g, 24.656 mmol), hexane-2,5-dione (3.377 g, 29.59 mmol) and p-TSA (93.8 mg, 0.49 mmol) in toluene (50 mL) was heated to reflux for 36 h. The mixture was concentrated under reduced pressure. The crude product was purified by column chromatography over silica gel (petroleum ether/ethyl acetate from 100/0 to 0/100). The desired fractions were collected and the solvent was concentrated under reduced pressure to afford the title product (3.3 g, 42.7% yield) as a white solid. LCMS (ESI) m/z M+1: 302.9.

Reference： [1]Patent: US2018/170909,2018,A1 .Location in patent: Paragraph 1680; 1681

11
2'-O-acetyl-2-F-3-O-descladinosyl-3-keto-6-O-methylerythromycin A 9-O-propargyl oxime 11,12-cyclic carbonate [ No CAS ]
[ 55270-27-4 ]
2-fluoro-3-O-descladinosyl-3-oxo-6-O-methylerythromycin A-9-O-[3-(1'-aminoisoquinol-4'-yl)-2-propargyl]oxime-11,12-cyclic carbonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
3.01%		General procedure: To a solution of CuI (0.1 eq), Pd(PPh3)2Cl2 (0.05 eq) and compound7 (1 eq) in MeCN (5 mL) were added ArBr (Ar a, b, c, e, f, g,h, k, l) or ArI (Ar q, r, s, t) (3 eq) and trimethylamine (1.5 eq). Thereaction mixture was flushed with argon and sealed in a pressuretube. The reaction mixture was stirred at 80 C for 3-4 h. The reactionmixture was extracted with EtOAc, washed with water andbrine and concentrated in vacuo. The product was dissolved inMeOH (15 mL) at 60 C for 1 h. The organic solvent was removed invacuum. The crude mixture was purified by column chromatographyon silica gel to give 8a, 8b, 8c, 8e, 8f, 8g, 8h, 8k, 8l, 8q, 8r, 8s,8t.To a solution of ArI (Ar = n, p) (3 eq) in MeCN (5 mL) was addedtrimethylamine (5 mL). The mixture was stirred at room temperaturefor 1 h, after which time CuI (0.1 eq), Pd(PPh3)2Cl2 (0.05 eq)and compound 7 (1 eq) were added. The reaction mixture wasflushed with argon and sealed in a pressure tube. The reactionmixture was stirred at 50 C for 24 h. The reaction mixture wasextracted with EtOAc, washed with water and brine and concentratedin vacuum. The product was then dissolved in MeOH (15 mL)at 60 C for 1 h. The organic solvent was removed in vacuo. Thecrude mixturewas purified by column chromatography on silica gelto give 8n and 8p.

Reference： [1]European Journal of Medicinal Chemistry,2019,vol. 169,p. 1 - 20

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[ 55270-27-4 ]

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Physical hazards
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
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H220	Extremely flammable gas
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H222	Extremely flammable aerosol
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
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H242	Heating may cause a fire
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H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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Health hazards
Code	Phrase
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H302	Harmful if swallowed
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H311	Toxic in contact with skin
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H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
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H333	May be harmful if inhaled
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Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 55270-27-4 ]

Quality Control of [ 55270-27-4 ]

Related Doc. of [ 55270-27-4 ]

Product Details of [ 55270-27-4 ]

Calculated chemistry of of [ 55270-27-4 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 55270-27-4 ]

Application In Synthesis of [ 55270-27-4 ]

[ 55270-27-4 ] Synthesis Path-Upstream 1~1

[ 55270-27-4 ] Synthesis Path-Downstream 1~11

Related Functional Groups of [ 55270-27-4 ]

Bromides

Amines

Related Parent Nucleus of [ 55270-27-4 ]

Isoquinolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 55270-27-4 ]

Related Parent Nucleus of
[ 55270-27-4 ]