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[ CAS No. 1532-84-9 ]

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Chemical Structure| 1532-84-9
Chemical Structure| 1532-84-9
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CAS No. :1532-84-9 MDL No. :MFCD00024137
Formula : C9H8N2 Boiling Point : 323.9°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :144.17 g/mol Pubchem ID :73742
Synonyms :

Safety of [ 1532-84-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1532-84-9 ]

  • Upstream synthesis route of [ 1532-84-9 ]
  • Downstream synthetic route of [ 1532-84-9 ]

[ 1532-84-9 ] Synthesis Path-Upstream   1~13

  • 1
  • [ 1532-84-9 ]
  • [ 19493-44-8 ]
Reference: [1] Canadian Journal of Chemistry, 2005, vol. 83, # 3, p. 213 - 219
  • 2
  • [ 1532-84-9 ]
  • [ 491-30-5 ]
  • [ 19493-44-8 ]
Reference: [1] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920, vol. 50, p. 544[2] Chem. Zentralbl., 1923, vol. 94, # III, p. 1023
  • 3
  • [ 119-65-3 ]
  • [ 1532-84-9 ]
Reference: [1] Journal of the American Chemical Society, 2016, vol. 138, # 29, p. 9166 - 9171
[2] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920, vol. 50, p. 544[3] Chem. Zentralbl., 1923, vol. 94, # III, p. 1023
[4] Journal of Organic Chemistry, 1937, vol. 2, p. 411,427[5] Justus Liebigs Annalen der Chemie, 1935, vol. 515, p. 34,37
[6] Pharmaceutical Bulletin, 1957, vol. 5, p. 606,609
[7] Journal of Organic Chemistry, 1946, vol. 11, p. 239,242
  • 4
  • [ 19493-44-8 ]
  • [ 1532-84-9 ]
Reference: [1] Organic Letters, 2013, vol. 15, # 14, p. 3734 - 3737
[2] Chemistry - A European Journal, 2010, vol. 16, # 6, p. 1983 - 1991
  • 5
  • [ 850705-46-3 ]
  • [ 1532-84-9 ]
  • [ 850705-51-0 ]
YieldReaction ConditionsOperation in experiment
8%
Stage #1: With sodium carbonate In water at 70℃; for 5 h;
Stage #2: With phosphoric acid In water
The mixture of diastereoisomers (150 mg, 0.52 mmol) described in section 1-e (compound 4), in solution in soda (1 mol L-1, 2 mL), is heated to 70° C. for 5 hours. After cooling, the solution is neutralised (pH 7.2) with a phosphoric acid solution. After extraction with dichloromethane (3 times 10 mL) and evaporation of the solvent, the residue is chromatographed on a silica column (deposit: dichloromethane, elution: dichloromethane/methanol mixture). After evaporation of the solvent, two products are isolated: the expected derivative in the form of a yellow solid (8 mg, 0.04 mmol, 8percent) and the 1-aminoisoquinoline (21 mg, 0.15 mmol, 28percent) characterised by 1H NMR and 13C spectroscopy.
Reference: [1] Patent: US2006/258612, 2006, A1, . Location in patent: Page/Page column 17
  • 6
  • [ 19658-76-5 ]
  • [ 1532-84-9 ]
  • [ 209416-32-0 ]
Reference: [1] Patent: US6114530, 2000, A,
  • 7
  • [ 1532-71-4 ]
  • [ 1532-84-9 ]
Reference: [1] Advanced Synthesis and Catalysis, 2013, vol. 355, # 4, p. 627 - 631
  • 8
  • [ 7159-36-6 ]
  • [ 1532-84-9 ]
Reference: [1] Journal of the American Chemical Society, 1940, vol. 62, p. 3030
  • 9
  • [ 1532-72-5 ]
  • [ 1532-84-9 ]
Reference: [1] Journal of Organic Chemistry, 2007, vol. 72, # 12, p. 4554 - 4557
  • 10
  • [ 19658-76-5 ]
  • [ 1532-84-9 ]
Reference: [1] Liebigs Annalen der Chemie, 1990, # 7, p. 653 - 657
  • 11
  • [ 76195-91-0 ]
  • [ 1532-84-9 ]
  • [ 93-07-2 ]
Reference: [1] Acta Chimica Academiae Scientiarum Hungaricae, 1980, vol. 103, # 2, p. 259 - 270
  • 12
  • [ 119-65-3 ]
  • [ 108-88-3 ]
  • [ 1532-84-9 ]
Reference: [1] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920, vol. 50, p. 544[2] Chem. Zentralbl., 1923, vol. 94, # III, p. 1023
  • 13
  • [ 1532-84-9 ]
  • [ 55270-27-4 ]
Reference: [1] Journal of Organic Chemistry, 2001, vol. 66, # 4, p. 1310 - 1315
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