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Chemical Structure| 55426-74-9 Chemical Structure| 55426-74-9

Structure of 55426-74-9

Chemical Structure| 55426-74-9

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Product Details of [ 55426-74-9 ]

CAS No. :55426-74-9
Formula : C11H15NO2
M.W : 193.24
SMILES Code : O=C(OCC)C1=CC=CC=C1N(C)C
MDL No. :MFCD00009110

Safety of [ 55426-74-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 55426-74-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 55426-74-9 ]

[ 55426-74-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 784-04-3 ]
  • [ 55426-74-9 ]
  • [ 157522-93-5 ]
  • 25-hydroxy-16-ene-23-yne-vitamin D3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
8.35 g (46.4%) In ethanol; hexane; dichloromethane; toluene; EXAMPLE 9 Preparation of (3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19),16-tetraen-23-yne-3,25-diol A solution of 18.0 g (45.6 mmol) (3beta)-cholesta-5,7,16-trien-23-yne-3,25-diol, 3.6 g ethyl dimethylaminobenzoate, and 1.7 L ethanol at -20 C. was irradiated with a 450 watt medium pressure lamp through a quartz immersion well for 7 hr. A uranium filter was inserted in the arc housing, and then 180 mg of <strong>[784-04-3]9-acetylanthracene</strong> was added to the solution. After 2 hr. of irradiation through the filter at 0 to -20 C., the solution was allowed to warm to room temperature overnight. The solvent was removed under reduced pressure. The residual ethanol was removed by co-evaporation with toluene. Then, the residue was suspended in 400 mL of toluene. After dilution with 400 mL of hexane, the suspension was stored in a refrigerator overnight. The precipitate was filtered and washed with 200 mL of toluene/hexane (1:1) and then with 400 mL toluene. The combined filtrate and washes were concentrated to about 400 mL of the volume. This solution was stirred at 90-100 C. (bath temperature) for 2 hr and then allowed to cool to room temperature overnight. The solution was concentrated to dryness and then purified by chromatography on silica gel eluding with 5-10% CH3 CN in CH2 Cl2 to give 8.35 g (46.4%) of (3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19),16-tetraen-23-yne-3,25-diol as a foam. This material was used in the next step without any further purification.
 

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