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Chemical Structure| 55488-81-8 Chemical Structure| 55488-81-8

Structure of 55488-81-8

Chemical Structure| 55488-81-8

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Product Details of [ 55488-81-8 ]

CAS No. :55488-81-8
Formula : C8H6BrClO3
M.W : 265.49
SMILES Code : O=C(OC)C1=CC(Br)=C(Cl)C=C1O
MDL No. :MFCD09800924

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Application In Synthesis of [ 55488-81-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 55488-81-8 ]

[ 55488-81-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1398331-98-0 ]
  • [ 55488-81-8 ]
  • C18H17ClO4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate; In 1,4-dioxane; dichloromethane; at 100℃; for 5.0h;Inert atmosphere; Taking compound 3 a (133 mg, 0.5 mmol), compound 4 a (151 mg, 0 . 55 mmol), PdCl2(Dppf) DCM (20 mg, 0 . 025 mmol) and potassium carbonate (207 mg, 1.5 mmol) is placed in a thick-wall pressure reaction tube, add 1, 4 - dioxane (2 ml), nitrogen advocated for 5 min, for 100 C heating 5 h. TLC monitoring display after the reaction. Placing to room temperature, filtered through diatomaceous earth, to ethyl acetate (10 ml) washing, turns on lathe does the filtrate, the residue by silica gel column chromatography (petroleum ether: ethyl acetate=15:1) purification to obtain compound 5 a (white solid, 130 mg, yield 78%).
 

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