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CAS No. : | 56724-03-9 | MDL No. : | MFCD11044581 |
Formula : | C9H10O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | VUVSSLDCCMJFTM-UHFFFAOYSA-N |
M.W : | 150.17 | Pubchem ID : | 13162663 |
Synonyms : |
|
Num. heavy atoms : | 11 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.22 |
Num. rotatable bonds : | 2 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 43.29 |
TPSA : | 26.3 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -5.54 cm/s |
Log Po/w (iLOGP) : | 1.82 |
Log Po/w (XLOGP3) : | 2.36 |
Log Po/w (WLOGP) : | 1.82 |
Log Po/w (MLOGP) : | 1.44 |
Log Po/w (SILICOS-IT) : | 2.44 |
Consensus Log Po/w : | 1.98 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.53 |
Solubility : | 0.444 mg/ml ; 0.00295 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.55 |
Solubility : | 0.421 mg/ml ; 0.0028 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -2.84 |
Solubility : | 0.216 mg/ml ; 0.00144 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.08 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P305+P351+P338-P304+P340-P405-P501 | UN#: | N/A |
Hazard Statements: | H302 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | 4.1.1.56 3-Methoxy-2-methylbenzaldehyde 58 N',N',N'-Trimethylethylene diamine (1.84 mL, 14.3 mmol) was dissolved in benzene (25 mL) and cooled to 0 C. n-BuLi (5.5 mL, 13 mmol) was added dropwise, and the reaction mixture was stirred for 10 min at room temperature. The reaction mixture was again cooled to 0 C, and m-anisaldehyde (1.54 mL, 13.3 mmol) was added. The reaction mixture was stirred for 15 min at room temperature and then cooled to 0 C. Phenyllithium (22.0 mL, 40.0 mmol) was added dropwise. The reaction mixture was stirred for 12 h at room temperature. THF (20 mL) was then added, and the reaction mixture was cooled to -78 C. Methyl iodide (5.0 mL, 80 mmol) was added dropwise, and the reaction mixture was stirred for 30 min at room temperature. The reaction mixture was poured into cold 10% HCl (50 mL) and extracted with EtOAc (3 * 30 mL). The combined organic phase was dried over sodium sulfate and evaporated under reduced pressure. The crude reaction product was purified using a pre-packed 50 g silica column [solvent A: EtOAc; solvent B: hexanes; gradient: 2% A/98% B (1 CV), 2% A/98% B ? 20% A/80% B (10 CV), 20% A/80% B (2 CV); flow rate: 40 mL/min; monitored at 254 and 280 nm] to afford 3-methoxy-2-methylbenzaldehyde (2.01 g, 14.3 mmol, 98%) as a yellow oil. 1H NMR (500 MHz, CDCl3) delta 9.97 (1H, s), 7.10 (1H, d, J = 8 Hz), 6.98 (1H, t, J = 8 Hz), 6.74 (1H, d, J = 8 Hz), 3.54 (3H, s), 2.23 (3H, s). 13C NMR (125 MHz, CDCl3) delta 192.0, 157.8, 134.9, 128.9, 126.3, 122.7, 114.8, 55.3, 10.0. | |
To a solution of Nu,Nu,Nu'-trimethylethylenediamine (7.1 ml) in toluene (140ml) was added dropwise at 0C nBuLi 1.6M in hexanes (33ml) under nitrogen. The mixture was stirred at rt for 1 h. 3-methoxybenzaldehyde (6.27ml) was added at 0C and the reaction mixture was stirred at rt for 1 h. Phenyllithium 1.8M in di-N-butylether (86ml) was added at 0C and the reaction mixture was stirred at rt overnight. The mixture was cooled down to -75C and iodomethane (19.2ml) was slowly added. The solution was stirred at rt for 4h. The mixture was diluted in cold 10% aq. HCI and the aq. layer was washed three times with EA. The combined org. layers were washed with sat. aq. NaCI, dried over MgS04, filtrated off and evaporated in vacuo. The crude was purified by CC (Buchi Sepacore, 100g cartridge, solvent A: Heptane , solvent B: EA, gradient in %B: 1 to 7 , flow rate: 40 ml/min) to afford 5.75g of a yellow oil. LC-MS (A): tR = 0.78min; [M+H]+: not visible. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a sol. of compound Cl with its regioisomer (1.64 g; 2.853 mmol; 1 eq.) in CH2Cl2 (32 mL) were added at rt cyclopropyl-(3-methoxy-2-methylbenzyl)amine (prepared by reductive amination from 3-methoxy-2-methylbenzaldehyde, Comins, D. L.; Brown, J. D., J. Org. Chem., 1989, 54, 3730 and cyclopropylamine, 1.64 g, 8.56 mmol), DIPEA (1.95 mL, 11.39 mmol) DMAP (87 mg, 0.71 mmol), HOBt (578 mg, 4.28 mmol), and EDC-HCl (2.19 g, 11.413 mmol). The mixture was stirred at rt for 3 days. CH2Cl2 (50 mL) was added to the reaction mixture, and the sol. was washed with aq. IM HCl (3x). The combined aq. layers were extracted with CH2Cl2 (25 mL). The combined org. extracts were washed with aq. sat. NaHCO3 (25 mL). The org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (CH2C12/CH3OH 100/3) yielded the title compound (1.45 g, 68%). LC-MS: tR = 1.29 min. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
(a) N-Benzoyl-3-(3'-methoxy-2'-methyl-phenyl) methyl ester 3-Methoxy-2-methyl-aniline were converted into 3-methoxy-2-methyl-benzaldehyde by the method of Beech (see Example 7). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 2h;Heating / reflux; | 5-Bromo-2-[2-(3-methoxy-2-methylphenyl)-vinyl]-benzoic acid methyl ester (5); To a stirred mixture of (4-bromo-2-methoxycarbonylbenzyl)-triphenylphosphonium bromide (4) (34.2 g; 60.0 mmol), DBU (1,8-diazabicyclo(5.4.0) undec-5-ene; 20.1 g; 132 mmol), and 3-methoxy-2-methylbenzaldehyde (7.21 g; 48.0 mmol) in acetonitrile were heated at reflux temperature for 2 hours. The mixture was cooled and the solvent was evaporated. The residue was partitioned between water and ethyl acetate and the organic phase was washed with 0.1 N HCl, water, and brine. The solution was dried over MgSO4, filtered, and evaporated. The residue was crystallized from ethyl acetate and hexane to yield compound 5 (14.5 g; 84%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With pyridinium chlorochromate; In dichloromethane; at 20℃; for 3.5h; | A stirred suspension of pyridinium chlorochromate (19.2 g; 89.2 mmol) in dichloromethane at ambient temperature was treated with a solution of (3-methoxy-2-methylphenyl)methanol (9.05 g; 59.47 mmol) in dichloromethane. The reaction solution immediately turned a greenish-brown color. The reaction was stirred for 3.5 hr, diluted 50% with diethyl ether and decanted. The brown gummy residue was triturated twice more with diethyl ether (40 mL) and the ether extracts were combined and evaporated to yield a yellow oil. The oil was passed through a column of silica gel with an ether/hexane mixture to yield the title product, 8.74 g; 97% yield. |
85% | With pyridinium chlorochromate; In dichloromethane; at 20℃; for 12h;Inert atmosphere; | To a well-stirred pyridinium chlorochromate (PCC) in CH2Cl2 (40 mL) solution, (3-methoxy-2-methylphenyl)methanol (3.22 g, 21.2 mmol) dissolved in CH2Cl2 (25 mL) was slowly added.The reaction mixture was stirred at room temperature for 12 h. The mixture was filtered throughCelite, and the Celite was washed thoroughly with CH2Cl2 (2 x 30 mL). The filtrate wasconcentrated under reduced pressure and purified by flash chromatography using a prepacked100 g silica column [solvent A: EtOAc; solvent B: hexanes; gradient: 7% A/ 93% B (3 CV), 7%A/ 93% B ? 60% A/ 40% B (10 CV), 60% A/ 40% B (1 CV); flow rate: 25 mL/min; monitoredat 254 and 280 nm] affording the aldehyde (2.70 g, 18 mmol, 85%) as a colorless oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ammonium acetate; at 100℃; for 1h; | Preparation 9: 2-Methyl-1 -(methyloxy)-3-[(E)-2-nitroethenyl]benzene. To a solution of 2-methyl-3-(methyloxy)benzaldehyde (available from Allichem Product List; 2Og; 133 mmol) in nitromethane (400ml) was added ammonium acetate(6.16g; 80 mmol) and the resulting orange mixture was stirred for 1 h at 1000C then cooled to room temperature and concentrated in vacuo. The residue was partitioned between ethyl acetate (x2) and brine, and the organic layers washed with brine, dried(MgSC>4) and concentrated in vacuo. Trituration with dichloromethane/ ether gave the title compound as a yellow solid (6.6g).1H NMR (CDCI3) delta: 8.35 (d, 1 H), 7.48 (d, 1 H), 7.22 (t, 1 H), 7.11 (d, 1 H), 6.96 (d, 1 H), 3.86 (s, 3H), 2.33 (s, 3H)After evaporation of the mother liquors further product (7.22g) was obtained by trituration with diethyl ether. The mother liquors were again evaporated, and the residue was purified by chromatography, eluting with 5-10% ethyl acetate in cyclohexane, to give further product (3.45g) after trituration with ether. | |
With ammonium acetate; at 100℃; for 1h; | Preparation 9: 2-Methyl-1-(methyloxy)-3-[(E)-2-nitroethenyl]benzene. To a solution of 2-methyl-3-(methyloxy)benzaldehyde (available from Allichem Product List; 20.Og; 133 mmol) in nitromethane (400ml) was added ammonium acetate (6.16g; 80.0 mmol) and the resulting orange mixture was stirred for 1 h at1000C then cooled to room temperature and concentrated in vacuo. The residue was partitioned between ethyl acetate (x2) and brine, and the organic layers washed with brine, dried (MgSO4) and concentrated in vacuo. Trituration with dichloromethane/ ether gave the title compound as a yellow solid (6.6Og).1H NMR (CHLOROFORM-d) delta: 8.35 (d, 1 H), 7.48 (d, 1 H), 7.22 (t, 1 H), 7.1 1 (d, 1 H),6.96 (d, 1 H), 3.86 (s, 3H), 2.33 (s, 3H). | |
975 mg | With ammonium acetate; at 100℃; for 1h; | To a solution of 3-methoxy-2-methylbenzaldehyde (1g) in nitromethane (20ml) was added ammonium acetate (310mg). The reaction mixture was stirred at 100C for 1 h. The solution was evaporated in vacuo and the residue was diluted with EA (50ml). The org. layer was washed twice with sat. aq. NaCI, the combined org. layers were dried over MgS04, filtrated off and evaporated in vacuo. The crude was purified by CC (Buchi Sepacore, 50g cartridge, solvent A: heptane, solvent B: EA, gradient in %B: 1 , flow rate: 30ml/min) to afford 975mg of a yellow oil. LC-MS (A): tR = 0.89min; [M+H]+: not visible. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; at 20℃;Cooling with ice; | To an ice-cooled and stirred suspension of 3-methoxy-2-methylbenzaldehyde (0.269 g, 1.8 mmol) in ethanol (15 ml) a solution of NaOAcJH2O (1.3 eq) and NH2ORHCl (1.3 eq) in water (5 ml) was added dropwise within 5 minutes. The resulting suspension was stirred at room temperature until the starting material was consumed (monitored by TLC). After evaporation of the ethanol in vacuo, water was added to the residue. Then the precipitated crystals were filtered off. The crude product was purified by column chromatography with a mixture of chloroform: ethyl acetate (95:5) as the eluent.Yield: 0.218 g (74%), white crystals. Mp.: 1100C.1H NMR (CDCl3): 2.29 (s, 3H, Ar-CH3); 3.84 (s, 3H, N-CH3); 6.88 (d, IH, Ar); 7.18 (t, IH, Ar); 7.30 (d ,1H, Ar); 8.42 (s, IH, CH); 8.47 (s, IH, N-OH).Analysis calculated for C9H11NO2 (165.19): C 65.44%, H 6.71%, N 8.48%. Found: C 65.45%, H 6.64%, N 8.45%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | 4.1.1.57 5-(3'-Methoxy-2'-methylphenyl)pent-4-enoic acid (3) To dissolved 3-(carboxypropyl)triphenyl phosphonium bromide (6.55 g, 15.3 mmol) in THF was added potassium tert-butoxide (3.30 g, 29.0 mmol), and the reaction mixture was stirred at room temperature for 1 h. <strong>[56724-03-9]<strong>[56724-03-9]3-Methoxy-2-methylbenzaldehyd</strong>e</strong> (2.01 g, 13.4 mmol) dissolved in THF was added to the original reaction mixture, and the reaction mixture was stirred at room temperature for 12 h. The THF was evaporated, and the resulting material was quenched with 2 M HCl (75 mL) and extracted with EtOAc (3 * 100 mL). The combined organic phase was evaporated under reduced pressure and purified by flash chromatography using a pre-packed 100 g silica column [solvent A: EtOAc; solvent B: hexanes; gradient: 12% A/88% B (1 CV), 12% A/88% B ? 75% A/25% B (10 CV), 75% A/25% B (2 CV); flow rate: 40 mL/min; monitored at 254 and 280 nm] to afford carboxylic acid 3 (2.12 g, 9.62 mmol, 69%) as a yellow oil. NMR characterization was performed after the next step. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | General procedure: To a solution of the hydroxy-methylbenzaldehyde (34 mg,0.25 mmol) in anhydrous DMF (6.0 mL), K2CO3 (35 mg,0.25 mmol) was added and the mixture was stirred at room temperaturefor 30 minutes. Then, methyl iodide (30 muL, 68 mg,0.5 mmol) was added and the reaction was stirred at room temperatureovernight. The reaction was quenched by the additionof distilled water, and the aqueous phase was extracted threetimes with ethyl acetate. The combined organic phases weredried with MgSO4 and concentrated in vacuo. The residue waspurified by column chromatography on silica gel. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In toluene; at 20 - 25℃; for 24h;Inert atmosphere; | 28) 3-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-1-methyl-1H-pyrazole-5-carboxamide To a solution of aldehyde (1.0 g, 6.66 mmol, 1.0 eq) in toluene (20 mL) was added 2,4-dimethoxybenzyl amine (1.23 g, 7.33 mmol, 1.1 eq) and the reaction mixture was stirred at room temperature for 24 h. Toluene was removed to give a residue, which was taken in MeOH (25 mL) and then NaBH4 (506 mg, 13.32 mmol, 2.0 eq) was added slowly. The reaction mixture was stirred at room temperature for 6 h. Solvent was removed and the residue was extracted in ethyl acetate and stirred with saturated aq NaHCO3 for 1 h. The organic layer was collected, dried and solvent was removed to give the crude amine, which was used in the next step without further purification. To a solution of the crude amine (4.44 mmol, 1.0 eq) in DMF (15 mL) was added the acid (737 mg, 4.44 mmol, 1.0 eq), DIEA (2.86 g, 22.2 mmol, 5 eq) and HBTU (2.02 g, 5.38 mmol, 1.2 eq) and the reaction mixture was stirred at rt for 12 h. The reaction mixture was then diluted with ethyl acetate (20 mL) and washed with 10% aqHCl (1*20 mL), sat NaHCO3 (1*20 mL) and water (4*20 mL). Organic layer was collected, dried (MgSO4) and evaporated to give a crude product, which was purified by column chromatography (EtOAc/Hexane 25% to 75%)) to give the amide, which was directly used in the next step. The amide was treated with 95% TFA:H2O for 12 h. TFA was removed and azeotroped with toluene to give a residue, which was purified by column chromatography (EtOAc/Hexane 10% to 50%) to give the desired product (80 mg, >95% purity). Mass Spectrum (LCMS, ESI Pos.) Calcd. For C17H22N3O2: 300.0 (M+H), Found 300.0. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With ammonium acetate; acetic acid; at 80℃; for 1.83333h;Inert atmosphere; | Nitromethane (427 mg, 6.99 mmol) and freshly sublimatedammonium acetate (433 mg, 5.62 mmol) were added to a solution of 3-methoxy-2-methylbenzaldehyde(11, 800 mg, 5.33 mmol) in acetic acid (645 mg, 10.74 mmol), and the mixture was stirred at80 C for 1 h 50 min. After cooling to room temperature, the precipitate was dissolved by addingethyl acetate. The mixture was transferred to a separatory funnel, and then washed twice withwater and brine. The aqueous layer was extracted with ethyl acetate, the combined organic layerswere dried (magnesium sulfate), and the solvent was evaporated. Purification of the residue bycolumn chromatography (silica gel, petroleum ether/ethyl acetate, 1% to 15% ethyl acetate) provided1-methoxy-2-methyl-3-(2-nitrovinyl)benzene (791mg, 4.09mmol, 77%) as yellowcrystals. M.p. 97-98 C;UV (MeOH): l = 205, 228, 251, 317 nm; IR (ATR): n = 3116, 2959, 2920, 2838, 1901, 1820, 1697, 1653,1627, 1594, 1573, 1541, 1498, 1477, 1450, 1331, 1260, 1244, 1102, 1080, 1007, 968, 893, 873, 844, 806,777, 725, 693 cm-1; 1H-NMR (500 MHz, CDCl3): d = 2.33 (s, 3H), 3.86 (s, 3H), 6.96 (d, J = 8.2 Hz, 1H),7.10 (d, J = 7.8 Hz, 1H), 7.22 (t, J = 8.0 Hz, 1H), 7.48 (d, J = 13.5 Hz, 1H), 8.33 (d, J = 13.5 Hz, 1H);13C-NMR (125 MHz, CDCl3): d = 11.96 (CH3), 55.84 (CH3), 113.12 (CH), 119.25 (CH), 127.11 (CH),128.40 (C), 130.13 (C), 137.25 (CH), 138.20 (CH), 158.29 (C); MS (EI): m/z (%) = 193 (100, [M]+), 178 (6),161 (7), 146 (70), 131 (52), 115 (54), 103 (67), 91 (37), 77 (47), 63 (18), 51 (18); HRMS: calcd. for C10H11NO3:193.0738, found: 193.0733; elemental analysis: calcd. for C10H11NO3: C: 62.17, H: 5.74, N: 7.25; found:C: 62.16, H: 5.77, N: 7.50. |
Tags: 56724-03-9 synthesis path| 56724-03-9 SDS| 56724-03-9 COA| 56724-03-9 purity| 56724-03-9 application| 56724-03-9 NMR| 56724-03-9 COA| 56724-03-9 structure
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P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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