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Chemical Structure| 56935-71-8 Chemical Structure| 56935-71-8

Structure of 56935-71-8

Chemical Structure| 56935-71-8

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Product Details of [ 56935-71-8 ]

CAS No. :56935-71-8
Formula : C8H7F3N2O2
M.W : 220.15
SMILES Code : N=C(NO)C1=CC=C(OC(F)(F)F)C=C1
MDL No. :MFCD00085175

Safety of [ 56935-71-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 56935-71-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56935-71-8 ]

[ 56935-71-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 56935-71-8 ]
  • [ 41716-18-1 ]
  • [ 1570043-57-0 ]
YieldReaction ConditionsOperation in experiment
40% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 140℃; Step 1 5-(1-Methyl-1H-imidazol-4-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole [0450] To a solution of <strong>[41716-18-1]1-<strong>[41716-18-1]methyl-1H-imidazole-4-carboxylic acid</strong></strong> (1.5 g, 11.9 mmol) in DMF (30 mL), N-hydroxy-4-(trifluoromethoxy)benzimidamide (3.1 g, 14.3 mmol), HOBT (2.2 g, 14.3 mmol) and EDCI (2.7 g, 14.3 mmol) were added in sequence. The mixture was stirred at 140° C. overnight, then cooled to RT, quenched by water (100 mL), and extracted with EtOAc (2×50 mL). The combined organic phases were washed by water (3×50 mL) and brine (50 mL), dried over Na2SO4, filtered, and concentrated to afford the crude product, which was purified by silica gel column chromatography (EtOAc:Petroleum ether=1:5) to give 5-(1-methyl-1H-imidazol-4-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole as a white solid (1.8 g, 40.0percent). MS (ES+) C13H9F3N4O2 requires: 310. found: 311 [M+H]+.
 

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