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Chemical Structure| 57235-54-8 Chemical Structure| 57235-54-8

Structure of 57235-54-8

Chemical Structure| 57235-54-8

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Product Details of [ 57235-54-8 ]

CAS No. :57235-54-8
Formula : C7H11N3S
M.W : 169.25
SMILES Code : NC1=NN=C(C2CCCC2)S1
MDL No. :MFCD01044255

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Application In Synthesis of [ 57235-54-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57235-54-8 ]

[ 57235-54-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1309774-03-5 ]
  • [ 57235-54-8 ]
  • N-(7-bromo-1,5-naphthyridin-2-yl)-5-cyclopentyl-1,3,4-thiadiazole-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.92 g With potassium carbonate; In water; dimethyl sulfoxide; at 130℃; for 0.5h; 0039-1 A solution of <strong>[1309774-03-5]7-bromo-2-chloro-1,5-naphthyridine</strong> (2.04 g), 5-cyclopentyl-1,3,4-thiadiazole-2-amine (1.41 g), and potassium carbonate (1.73 g) in dimethylsulfoxide (16 mL) was stirred at 130 C. for 3 hours. After the reaction mixture was cooled to room temperature, water was added thereto, and the solid matter was collected by filtration, thereby obtaining N-(7-bromo-1,5-naphthyridin-2-yl)-5-cyclopentyl-1,3,4-thiadiazole-2-amine (1.92 g). 1H-NMR (DMSO-d6) delta: 12.20 (1H, s), 8.84 (1H, d, J=2.7 Hz), 8.56 (1H, d, J=2.7 Hz), 8.31 (1H, d, J=9.3 Hz), 7.51 (1H, d, J=9.3 Hz), 3.56-3.40 (1H, m), 2.22-2.08 (2H, m), 1.94-1.34 (6H, m). MS m/z (M+H): 376, 378.
 

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