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Structure of 57273-36-6

Chemical Structure| 57273-36-6

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Chao Zhou ; Chengju Sheng ; Lingling Gao ; Jia Guo ; Peng Li ; Bo Liu

Abstract: The development of treatment of wound healing cannot meet clinical requirements owing to the complex bacteria-infection and inflammatory reaction. It is necessary to develop wound dressings that are fast antibacterial property, anti-inflammation and promoting cell migration and proliferation for shortening wound healing period. In this work, we first synthesized two poly(ionic liquids) (PILs): poly(1-ethyl-3-vinylimidazolium furan-2-carboxylate) (PEIF) and poly(1-butyl-3-vinylimidazolium furan-2-carboxylate) (PBIF). The PILs were then mixed with 5 wt% montmorillonite (MMT) clay and 2-furfurylamine-modified hyaluronic acid (HAF), and chemically crosslinked with four-arm maleimide-polyethylene glycol (Mal4PEG) to form degradable semi-inter penetrate network (semi-IPN) hydrogels. In vitro assays demonstrated that the synthesized semi-IPN hydrogels exhibited high antibacterial activities against Escherichia coli and Staphylococcus aureus due to the high antibacterial activity of PILs. Furthermore, the semi-IPN hydrogel could be quickly degraded, and the PILs exhibited high anti-inflammatory activities when they were released from degraded hydrogels. The degradation solutions of hydrogels contained glycosaminoglycan, which was beneficial to cell proliferation and migration. The in vivo anti-infection results further demonstrated that the semi-IPN hydrogels could kill S. aureus and accelerate the healing of infected wounds.

Keywords: Antibacterial activity ; Poly(ionic liquids) ; semi-IPN hydrogels ; Anti-inflammation ; Wound healing

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Product Details of [ 57273-36-6 ]

CAS No. :57273-36-6
Formula : C5H3NaO3
M.W : 134.07
SMILES Code : O=C(C1=CC=CO1)[O-].[Na+]
MDL No. :MFCD07783396

Safety of [ 57273-36-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
 

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