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Chemical Structure| 5738-14-7 Chemical Structure| 5738-14-7

Structure of 5738-14-7

Chemical Structure| 5738-14-7

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Product Details of [ 5738-14-7 ]

CAS No. :5738-14-7
Formula : C6H9N3O2
M.W : 155.15
SMILES Code : OC1=NC(N(C)C)=NC(O)=C1
MDL No. :MFCD01935970
InChI Key :ISZVFAGBGUCFPT-UHFFFAOYSA-N
Pubchem ID :320025

Safety of [ 5738-14-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 5738-14-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5738-14-7 ]

[ 5738-14-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5738-14-7 ]
  • [ 599-91-7 ]
  • [ 54028-42-1 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; EXAMPLE 11 2-Dimethylamino-4-n-propoxy-6-hydroxy-pyrimidine 124 g (0.8 mol) of 2-dimethylamino-4,6-dihydroxypyrimidine are stirred with 800 cc of 1N sodium hydroxide solution at 60° for 1 hour. 171 g (0.8 mol) of p-toluenesulphonic acid-n-propyl ester are added dropwise at 90° over the course of 1 hour and the pH is kept at 8-8.5 by the dropwise addition of 1N sodium hydroxide solution. The mixture is stirred at 90° for 16 hours, cooled to 5°, neutralized with glacial acetic acid and allowed to stand at room temperature for 6 hours. The precipitated crystals are subsequently filtered by suction, washed with water, dissolved in approximately 700 cc of chloroform, dried over sodium sulphate and evaporated to dryness in a vacuum. The residue is decomposed with 500 cc of petroleum ether, filtered by suction and recrystallized from benzene, washed with petroleum ether and dried at 60° in a high vacuum. M.P.: 194°-195°. Analysis: C9 H15 N3 O2. Molecular weight: 197.24. Calc.: C, 54.8 percent; H, 7.7 percent; N, 21.3 percent. Found: C, 54.5 percent; H, 7.7 percent; N, 21.3 percent.
With sodium hydroxide; EXAMPLE 49 2-Dimethylamino-4-n-propoxy-6-hydroxy-pyrimidine 124 g (0.8 mol) of 2-dimethylamino-4,6-dihydroxy-pyrimidine are stirred with 800 cc of sodium hydroxide solution 1N at 60° for 1 hour. 171 g (0.8 mol) of p-toluene-sulphonic acid-n-propyl ester are added dropwise at 90° over the course of 1 hour and the pH is kept at 8-8.5 by the dropwise addition of sodium hydroxide solution 1N. The mixture is stirred at 90° for 16 hours, cooled to 5°, neutralized with glacial acetic acid and allowed to stand at room temperature for 6 hours. The precipitated crystals are subsequently filtered by suction, washed with water, dissolved in approximately 700 cc of chloroform, dried over sodium sulphate and evaporated to dryness in a vacuum. The residue is decomposed with 500 cc of petroleum ether, filtered by suction and recrystallized from benzene, washed with petroleum ether and dried at 60° in a high vacuum. M.P.: 194°-195°
 

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[ 5738-14-7 ]

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Related Parent Nucleus of
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