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Chemical Structure| 57676-54-7 Chemical Structure| 57676-54-7

Structure of 57676-54-7

Chemical Structure| 57676-54-7

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Product Details of [ 57676-54-7 ]

CAS No. :57676-54-7
Formula : C9H12N2O
M.W : 164.20
SMILES Code : O=C(NN)CC1=CC=C(C)C=C1
MDL No. :MFCD08753835

Safety of [ 57676-54-7 ]

Application In Synthesis of [ 57676-54-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57676-54-7 ]

[ 57676-54-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 161601-29-2 ]
  • [ 57676-54-7 ]
  • [ 875899-03-9 ]
YieldReaction ConditionsOperation in experiment
Step B: ter/-butyl [(15,35)-3-({2-[(4-methylphenyl)acetyl]hydrazino}carbonyl)cyclopentyl]carbamate; A mixture of (15,35)-3-[(/e^butoxycarbonyl)amino]cyclopentanecarboxylic acid (1.10 g, 4.80 mmol), HOBt (0.78 g, 5.07 mmol), and EDC (0.97 g, 5.07 mmol) in methylene chloride (220 mL) and DMF (25 mL) was stirred at room temperature under N2. After 30 minutes, 2-(4-methylphenyl)acetohydrazide (0.80 g, 4.87mmol) was added to the reaction. After 14 hours, the gel-like mixture was poured into ethyl acetate. The organic layer was washed with 1 N sodium hydroxide, water, brine, dried over sodium sulfate, filtered and concentrated to yield the title compound (1.82 g) as a white solid. HRMS (M+Na+): calculated = 398.2050, observed = 398.2059.
  • 2
  • [ 57676-54-7 ]
  • [ 163266-02-2 ]
  • 1-(5-hydroxy-3-(o-tolyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-(p-tolyl)ethan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
20% In isopropyl alcohol; at 90℃; General procedure: A mixture of 2-phenylacetohydrazide (1) (0.10?g, 0.67?mmol) and 1,1,1-trifluoro-5-phenylpentane-2,4-dione (3a) (0.14?g, 0.67?mmol) in a solution of i-PrOH (5?mL) was heated at 90?C for 48?h. After cooling to room temperature, EtOAc and water were added. The EtOAc extract was washed with water, brine and dried (Na2SO4). Flash chromatography (petroleum ether/EtOAc; 100:0 to 93:7) followed by recrystallization from Et2O/petroleum ether gave 4 (0.17?g, 71%), mp 122-123?C (Et2O/petroleum ether).
  • 3
  • [ 53764-99-1 ]
  • [ 57676-54-7 ]
  • 1-(5-hydroxy-3-(m-tolyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-(p-tolyl)ethan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
50% In isopropyl alcohol; at 90℃; General procedure: A mixture of 2-phenylacetohydrazide (1) (0.10?g, 0.67?mmol) and 1,1,1-trifluoro-5-phenylpentane-2,4-dione (3a) (0.14?g, 0.67?mmol) in a solution of i-PrOH (5?mL) was heated at 90?C for 48?h. After cooling to room temperature, EtOAc and water were added. The EtOAc extract was washed with water, brine and dried (Na2SO4). Flash chromatography (petroleum ether/EtOAc; 100:0 to 93:7) followed by recrystallization from Et2O/petroleum ether gave 4 (0.17?g, 71%), mp 122-123?C (Et2O/petroleum ether).
 

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