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Chemical Structure| 5783-36-8 Chemical Structure| 5783-36-8

Structure of 5783-36-8

Chemical Structure| 5783-36-8

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Product Details of [ 5783-36-8 ]

CAS No. :5783-36-8
Formula : C14H12O3
M.W : 228.24
SMILES Code : O=C(C1=CC=C(C2=CC=CC(OC)=C2)C=C1)O
MDL No. :MFCD03424601

Safety of [ 5783-36-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 5783-36-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5783-36-8 ]

[ 5783-36-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1158758-77-0 ]
  • [ 5783-36-8 ]
  • C23H28N2O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 18h; General procedure: To a stirred solution of 3'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (228 mg, 1 mmol),and <strong>[1158758-77-0]tert-butyl 3-amino-3-methylazetidine-1-carboxylate</strong> (189.2 mg, 1.02 mmol.) and N,Ndiisopropyl-ethylamine (452.4 mg, 3.5 mmol) in DMF (5 mL) was added HBTU (1.32g, 3.48mmol). The resulting mixture was stirred at room temperature for 18 hours. The reactionmixture was partitioned between water (30 mL) and ethyl acetate (30 mL) and the aqueouslayer was extracted with ethyl acetate (50 mL). The combined organic extracts were washedwith saturated NaHCO3 (30 mL), and brine (30 mL). The organic layer was dried overNa2SO4 and concentrated under reduced pressure. The residue was purified on silica gel(Biotage; eluting solvents hexane: EtOAc 4/1 ratio) to afford tert-butyl 3-(3'-methoxy-[1,1'-biphenyl]-4-carboxamido)-3-methylazetidine-1-carboxylate as a colorless solid in 80% yield. 1H NMR (500 MHz, CDCl3) delta 7.83 (d, J = 8.4 Hz, 2H), 7.59 (d, J = 8.3 Hz, 2H), 7.34 (t, J =7.9 Hz, 1H), 7.15 (d, J = 7.7 Hz, 1H), 7.10 (d, J = 1.7 Hz, 1H), 7.04 (s, 1H), 6.94 - 6.87 (m,1H), 4.16 (s, 2H), 3.89 (d, J = 7.2 Hz, 2H), 3.84 (s, 3H), 1.67 (s, 3H), 1.43 (s, 9H).
 

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