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Chemical Structure| 5807-02-3 Chemical Structure| 5807-02-3

Structure of 5807-02-3

Chemical Structure| 5807-02-3

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Product Details of [ 5807-02-3 ]

CAS No. :5807-02-3
Formula : C6H10N2O
M.W : 126.16
SMILES Code : N#CCN1CCOCC1
MDL No. :MFCD00023372
InChI Key :OOSOCAXREAGIGA-UHFFFAOYSA-N
Pubchem ID :22055

Safety of [ 5807-02-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302+H332-H310-H315-H319
Precautionary Statements:P261-P262-P264-P270-P271-P280-P301+P312+P330-P302+P352+P310+P361+P364-P304+P340+P312-P305+P351+P338+P337+P313-P405-P501
Class:6.1
UN#:3439
Packing Group:

Application In Synthesis of [ 5807-02-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5807-02-3 ]

[ 5807-02-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 5807-02-3 ]
  • [ 885012-27-1 ]
  • [ 24973-50-0 ]
  • 2
  • [ 5807-02-3 ]
  • [ 1224731-01-4 ]
  • [ 13531-48-1 ]
  • 3
  • [ 5807-02-3 ]
  • [ 10268-71-0 ]
  • [ 6609-56-9 ]
YieldReaction ConditionsOperation in experiment
45% With 3,4-thiene-2,3-diylbis(dicyclohexylphosphine); nickel(II) acetate tetrahydrate; sodium carbonate; In 1,4-dioxane; at 160℃; for 24h;Inert atmosphere; General procedure: A 20-mL glass vessel equipped with J. Young O-ring tap containing a magnetic stirring bar,Ni(OAc)2·4H2O (10.0 mg, 0.040 mmol, 10 mol%) and Na2CO3 (63.6 mg, 0.60 mmol, 1.5 equiv) weredried with a heatgun in vacuo and filled with N2 gas after cooling to room temperature. To this wereadded aromatic ester 1 (0.40 mmol, 1.0 equiv), 2-morpholinoacetonitrile (2a: 100.9 mg, 0.80 mmol,2.0 equiv) and dcypt (38.1 mg, 0.080 mmol, 20 mol%). The vessel was placed under vacuum andrefilled N2 gas three times, and then added 1,4-dioxane (1.6 mL). The vessel was sealed with O-ringtap and then heated at 150-160 C for 12 hours in an oil bath or 9-well reaction block with stirring.After cooling the reaction mixture to room temperature, the mixture was passed through a shortsilica-gel pad with EtOAc as an eluent. The filtrate was concentrated in vacuo. The residue waspurified by Isolera or PTLC to afford the corresponding aryl nitrile 3.
 

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