Home Cart Sign in  
Chemical Structure| 58244-42-1 Chemical Structure| 58244-42-1

Structure of 58244-42-1

Chemical Structure| 58244-42-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 58244-42-1 ]

CAS No. :58244-42-1
Formula : C8H8BrNO3
M.W : 246.06
SMILES Code : CCOC1=CC=C([N+]([O-])=O)C=C1Br
MDL No. :MFCD12547883

Safety of [ 58244-42-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 58244-42-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 58244-42-1 ]

[ 58244-42-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 58244-42-1 ]
  • [ 5847-59-6 ]
  • 2
  • [ 74-96-4 ]
  • [ 5847-59-6 ]
  • [ 58244-42-1 ]
YieldReaction ConditionsOperation in experiment
91% With potassium carbonate; In N,N-dimethyl-formamide; at 60℃; for 4h; Employing common literature protocols, 2-bromo-l-ethoxy-4-nitro-benzene (42a) was prepared through O-alkylation of commercial <strong>[5847-59-6]2-bromo-4-nitro-phenol</strong> (2.18 g, 10.0 mmol) with ethylbromide (EtBr) (3.0 mL, 4.36 g, 40 mmol) and potassium carbonate (K2C03) 5.53 g, 40 .0 mmol) in anhydrous N,N,-dimethylformamide (DMF) (30 mL) at 60C (oil bath) for 4 hours. Upon consumption of the starting material (TLC), insoluble solids were filtered off (Biichner-funnel), the filtrate was diluted with 1 molar (1M) hydrochloric acid (HC1) (70 mL), and the aqueous solution was extracted with a mixture of ethyl acetate (EtOAc) and hexane (1 : 1, v/v) (2x 70 mL). The combined organic xtracts were washed with brine, dired over anhydrous magnesium sulfate (MgS04), filtered, and the solvents were evaporated under reduced pressure using a rotary evaporator. The crude residue was purified by recrystallization from EtOAc/hexane (1 :20, 50 mL). The solids were collected on a Biichner-funnel and washed with hexane (50 mL). A second and third crop of the target compound (42a) was obtained from the mother liquor after partial evaporation and crystallization to furnish 2.23 g (91% yield) of the target compound (42a) as fine yellow needles. Rf: -0.34 (EtOAc/hexane = 1 :9, v/v); -0.25 (EtOAc/hexane = 1 : 19, v/v). 1H MR (300 MHz, CDCI3): delta 8.46 (d, J= 2.7 Hz, 1H), 8.18 (dd, J= 9.0, 2.7 Hz, 1H), 6.93 (d, J= 9.6 Hz, 1H), 4.21 (q, J= 6.9 Hz, 2H), 1.53 (t, J= 6.9 Hz, 3H) ppm.
 

Historical Records

Technical Information

Categories