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Chemical Structure| 59635-98-2 Chemical Structure| 59635-98-2

Structure of 59635-98-2

Chemical Structure| 59635-98-2

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Product Details of [ 59635-98-2 ]

CAS No. :59635-98-2
Formula : C9H12N2O
M.W : 164.20
SMILES Code : O=C(NN)C1=CC=CC=C1CC
MDL No. :MFCD08061557

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Application In Synthesis of [ 59635-98-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 59635-98-2 ]

[ 59635-98-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5683-31-8 ]
  • [ 59635-98-2 ]
  • 2-ethyl-N'-(3-(trimethylsilyl)propionoyl)benzohydrazide [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% 3- (trimethylsilyl) propiolic acid (678 mg, 4.77 mmol) in chloroform (10 ml) solution was added dropwise oxalyl chloride (438 mul, 5.01 mmol) under an argon atmosphere, at room temperature. Further added dropwise DMF (4 mul, 0.05 mmol), and stirred for 2 hours. Embodiment the compound obtained in Example 136-1 (783 mg, 4.77 mmol), was added triethylamine (731 mul, 5.25 mmol), and stirred for another 2 hours. Saturated saline, a saturated aqueous solution of sodium hydrogen carbonate was added, and the mixture was extracted with chloroform. Dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. Purification of the residue by flash column chromatography (hexane / ethyl acetate) to give the title compound (770 mg, 56%).
 

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