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Chemical Structure| 59786-37-7 Chemical Structure| 59786-37-7

Structure of 59786-37-7

Chemical Structure| 59786-37-7

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Product Details of [ 59786-37-7 ]

CAS No. :59786-37-7
Formula : C6H5NO2S
M.W : 155.17
SMILES Code : O=C(C1=CC=C(C=O)S1)N
MDL No. :MFCD12755846

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Application In Synthesis of [ 59786-37-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 59786-37-7 ]

[ 59786-37-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4565-31-5 ]
  • [ 79-37-8 ]
  • [ 59786-37-7 ]
  • [ 684-78-6 ]
  • 5-cyano-2-thiophenecarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; ammonium hydroxide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene; 1 5-Cyano-2-thiophenecarboxamide The compound of Reference Example 80 was synthesised by the following method. 5-Formyl-2-thiophenecarboxylic acid (2.64 g) (synthesised in accordance with the method described in Tetrahedron, 41, 3803 (1985)) was dissolved in tetrahydrofuran (30 ml), and N,N-dimethylformamide (3 drops) was added. Oxalyl chloride (2.2 ml) was added dropwise at room temperature, and the mixture was stirred for 2 hours. The reaction mixture was concentrated under reduced pressure and the concentrate was dissolved in ethyl acetate (50 ml). The resulting solution was added dropwise to a mixture of 25percent aqueous ammonia (50 ml) and ethyl acetate (200 ml) with stirring under ice-cooling. The resulting mixture was stirred at room temperature, and then the organic layer was collected. The aqueous layer was extracted twice with ethyl acetate. The organic layers were combined, dried over magnesium sulfate and concentrated under reduced pressure to give 5-formyl-2-thiophenecarboxamide (1.77 g). A mixture of 5-formyl-2- thiophenecarboxamide (1.55 g), N,O- bis(trifluoroacetyl)hydroxyamine (3.5 g), pyridine (2 ml) and toluene (110 ml) was stirred under reflux for 1 hour, and then cooled, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 5-cyano-2-thiophenecarboxamide (0.6 g). mp 222°-223° C.
 

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