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Chemical Structure| 60398-84-7 Chemical Structure| 60398-84-7

Structure of 60398-84-7

Chemical Structure| 60398-84-7

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Product Details of [ 60398-84-7 ]

CAS No. :60398-84-7
Formula : C8H10BrOP
M.W : 233.04
SMILES Code : CP(C)(C1=CC=CC(Br)=C1)=O
MDL No. :MFCD31736916
InChI Key :VAVCDNNDYJHWQQ-UHFFFAOYSA-N
Pubchem ID :129135203

Safety of [ 60398-84-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H302
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 60398-84-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 60398-84-7 ]

[ 60398-84-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 867044-28-8 ]
  • [ 60398-84-7 ]
  • C42H31OP [ No CAS ]
YieldReaction ConditionsOperation in experiment
59% General procedure: A three neck round bottom flask, equipped with dropping funnel, reflux condenser and magnetic stir bar is charged with boronie ester (i eq) and bromophenyldialkylphosphine oxide (i.e eq), the flask is sealed with a rubber septum, evacuated and back-filled with argon (2 times). Anhydrous TFIF (ioml/mmol of boronic ester) is added through the septum using a double-tipped needle. Separately, acatalyst is prepared by suspending of bis(dibenzylidenaceton)palladium (o 02 eq) and tri-tert-butyiphosphane (0.04 eq) in a small amount of anhycirous THF under Argon. The catalyst suspension is added to the reaction mixture through the septum with a syringe. Deoxygenated aqueous solution of tetrabutylammonium hydroxide (-20% wt, 2 eq) is added dropwise to the reaction mixture at room temperature (addition time-30 mm). Reaction mixture is stirred at room temperature for 2 h, precipitated product is separated by filtration, washed with water, methanol, and hexanc, dried in vacuum at 40 C for 48 h. Crude product is then triturated with hot dichloromethane/hexane mixture (1:1 vol, -300ml), hot filtered and dried in vacuum at 50 C for 1 h and at 1200 for 1 h. Final purification is achieved by sublimation in a high vacuum.
 

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