Home Cart Sign in  
Chemical Structure| 60547-95-7 Chemical Structure| 60547-95-7

Structure of 60547-95-7

Chemical Structure| 60547-95-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 60547-95-7 ]

CAS No. :60547-95-7
Formula : C15H16N2O3
M.W : 272.30
SMILES Code : O=C(N)C1=CC(OCC2=CC=CC=C2)=C(OC)C=C1N
MDL No. :MFCD28398156

Safety of [ 60547-95-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 60547-95-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 60547-95-7 ]

[ 60547-95-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 122-51-0 ]
  • [ 60547-95-7 ]
  • [ 286371-64-0 ]
YieldReaction ConditionsOperation in experiment
Heating / reflux; EXAMPLE 20; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(5,8-Dioxa-10-azadispiro[2.0.4.3]undecane) propoxy]quinazolin-4-amine 2-Amino-4-methoxy-5-benzyloxybenzamide (JMC, 20, 146) (5 g) was mixed with triethylorthoformate (15 ml) and refluxed overnight. The reaction solution was cooled and triturated with EtOAc (40 ml) then filtered to give 7-methoxy-6-benzyloxyquinazolone (3.2 g). This product was mixed with DIPEA (15 ml) and to the solution was added POCl3 (3 ml) slowly. The reaction mixture was refluxed for 30 minutes and cooled, then poured into a stirred mixture of ice and CHCl3. The solution was further extracted with CHCl3 three times and washed with H2O followed by brine, dried over Na2SO4 and evaporated to give a light brown solid as the chloride for next step without further purification. The above chloride (2 g) was mixed with 3-chloro-4-flouroaniline (1.3 g) in 2-propanol (30 ml) and the reaction was refluxed for 2 hours and cooled to RT. The precipitate was filtered and mixed with TFA (4 ml) and refluxed for 1 hour. The solvent was evaporated under reduced pressure and the residue was washed with EtOAc to furnish N-(3-chloro4-fluorophenyl)-7-methoxy-6-hydroxy-quinazolin-4-amine (1.3 g) that was mixed with K2CO3 (1.1 g) and 3-bromopropanol (850 muL) in DMF (5 ml). The reaction was heated at 80 C. overnight and poured into water and the precipitate was filtered to give N-(3-chloro4-fluorophenyl)-7-methoxy-6-(2-hydroxyethoxy)-quinazolin-4-amine (1 g). This hydroxy compound (350 mg) was mixed with DIPEA (350 muL) in DCM (10 ml) and cooled at 0 C, to the mixture was added MsCl (85 muL) and stirred for 2 hours. The reaction was evaporated with silica gel (2 g) and purified with silica gel column, then mixed with 5,8-Dioxa-10-azadispiro[2.0.4.3]undecane (B) (120 mg) and DIPEA (120 muL) in 2-propanol (10 ml). The reaction was refluxed overnight and evaporated then purified with silica gel column to give the titled product. Mass: (M+1), 515
 

Historical Records

Technical Information

Categories