Home Cart 0 Sign in  

[ CAS No. 60835-75-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 60835-75-8
Chemical Structure| 60835-75-8
Structure of 60835-75-8 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 60835-75-8 ]

Related Doc. of [ 60835-75-8 ]

Alternatived Products of [ 60835-75-8 ]

Product Details of [ 60835-75-8 ]

CAS No. :60835-75-8 MDL No. :MFCD00143277
Formula : C17H24O8 Boiling Point : -
Linear Structure Formula :- InChI Key :GFQYJVLOPVAPGJ-UHFFFAOYSA-N
M.W : 356.37 Pubchem ID :2724805
Synonyms :

Calculated chemistry of [ 60835-75-8 ]

Physicochemical Properties

Num. heavy atoms : 25
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.59
Num. rotatable bonds : 1
Num. H-bond acceptors : 8.0
Num. H-bond donors : 1.0
Molar Refractivity : 87.07
TPSA : 92.68 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : Yes
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -8.67 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.17
Log Po/w (XLOGP3) : -0.28
Log Po/w (WLOGP) : 1.22
Log Po/w (MLOGP) : -0.41
Log Po/w (SILICOS-IT) : 1.76
Consensus Log Po/w : 0.89

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.56

Water Solubility

Log S (ESOL) : -1.98
Solubility : 3.69 mg/ml ; 0.0104 mol/l
Class : Very soluble
Log S (Ali) : -1.21
Solubility : 22.1 mg/ml ; 0.0621 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -2.95
Solubility : 0.397 mg/ml ; 0.00111 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 3.34

Safety of [ 60835-75-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 UN#:N/A
Hazard Statements:H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 60835-75-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 60835-75-8 ]

[ 60835-75-8 ] Synthesis Path-Downstream   1~51

  • 1
  • [ 60835-75-8 ]
  • [ 104989-11-9 ]
  • 1,3,3-Trimethyl-9'-carboxybenzo-18-crown-6-spiro<indoline-naphthoxazine> [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide In dichloromethane Ambient temperature;
  • 2
  • [ 60835-75-8 ]
  • [ 155479-34-8 ]
  • [ 155479-35-9 ]
YieldReaction ConditionsOperation in experiment
93% With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane for 15h; Ambient temperature;
  • 3
  • [ 60835-75-8 ]
  • [ 155479-43-9 ]
  • [ 155479-44-0 ]
YieldReaction ConditionsOperation in experiment
59% With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane
  • 5
  • [ 60835-75-8 ]
  • 2,2',3',2''-tetramethoxy-[1,1';4',1'']ternaphthalene-3,3''-diol [ No CAS ]
  • C68H72O20 [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 12h;
  • 6
  • [ 60835-75-8 ]
  • [ 133463-87-3 ]
  • C55H66N2O18 [ No CAS ]
YieldReaction ConditionsOperation in experiment
45% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 72h;
  • 7
  • [ 60835-75-8 ]
  • [ 220108-58-7 ]
  • 6,7,9,10,12,13,15,16,18,19-Decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecene-2-carboxylic acid 6-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-pyridin-2-ylmethyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 6.5h;
  • 8
  • [ 60835-75-8 ]
  • [ 367272-32-0 ]
  • 6,7,9,10,12,13,15,16,18,19-Decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecene-2-carboxylic acid 3-[2,2-bis-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propyl]-phenyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 18h;
  • 9
  • [ 60835-75-8 ]
  • 3-amino-3-deoxy-β-cyclodextrin [ No CAS ]
  • N-(4'-carbonylbenzo-18-crown-6)-3-amino-3-deoxy-β-cyclodextrin [ No CAS ]
YieldReaction ConditionsOperation in experiment
23% With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0 - 20℃; for 13h;
  • 10
  • [ 60835-75-8 ]
  • 6-amino-6-deoxy-β-cyclodextrin [ No CAS ]
  • N-(4'-carbonylbenzo-18-crown-6)-6-amino-6-deoxy-β-cyclodextrin [ No CAS ]
YieldReaction ConditionsOperation in experiment
20% With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0 - 20℃; for 13h;
  • 11
  • [ 60835-75-8 ]
  • [ 797043-90-4 ]
  • C32H45N3O13 [ No CAS ]
YieldReaction ConditionsOperation in experiment
39% Stage #1: (benzo-18-crown-6)-4-carboxylic acid With thionyl chloride for 2h; Heating; Stage #2: N,N'-bis(5-hydroxy-3-oxapentyl)-2,6-pyridinedicarboxamide With triethylamine In tetrahydrofuran at 20℃; for 24h; Further stages.;
  • 12
  • [ 60835-75-8 ]
  • [ 5417-63-0 ]
  • [ 1004519-68-9 ]
YieldReaction ConditionsOperation in experiment
99% With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 0℃;
  • 13
  • [ 60835-75-8 ]
  • [ 113398-40-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: SOCl2 / Heating 2: 40 percent / pyridine / benzene / 5 h / Heating
  • 14
  • [ 60835-75-8 ]
  • [ 121612-97-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: SOCl2 / Heating 2: 66 percent / pyridine / benzene / Heating
  • 15
  • [ 60835-75-8 ]
  • C6H4(CH2C5H4)2SnO [ No CAS ]
  • [ 215233-45-7 ]
YieldReaction ConditionsOperation in experiment
98% In benzene byproducts: water; equimolar amts., refluxing for 10 h (distn. off of water); evapn. (vac.), recrystn. (Et2O/hexane); elem. anal.;
  • 16
  • dibutyltin(IV) oxide [ No CAS ]
  • [ 60835-75-8 ]
  • [(CH3(CH2)3)2SnOCOC16H23O6]4O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% In benzene stoich. amts., refluxing for 12 h; evapn. (vac.), chromy. (Sephadex LH-20, CH2Cl2/CHCl3), recrystn. (hexane/CHCl3); elem. anal.;
  • 17
  • dibutyltin(IV) oxide [ No CAS ]
  • [ 60835-75-8 ]
  • [ 257280-60-7 ]
YieldReaction ConditionsOperation in experiment
96% In benzene stoich. amts., refluxing for 6 h; evapn. (vac.), recrystn. (hexane/CHCl3); elem. anal.;
  • 18
  • [ 60835-75-8 ]
  • tribytyltin acetate [ No CAS ]
  • (CH3(CH2)3)3SnOCOC16H23O6*H2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% In benzene byproducts: AcOH; equimolar amts., refluxing for 4 h; evapn. (vac.), recrystn. (hexane/CHCl3); elem. anal.;
  • 19
  • [ 60835-75-8 ]
  • [ 475290-46-1 ]
  • [ 1096253-38-1 ]
YieldReaction ConditionsOperation in experiment
79% With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;
  • 20
  • [ 60835-75-8 ]
  • [ 688006-44-2 ]
  • [ 1258072-65-9 ]
YieldReaction ConditionsOperation in experiment
24% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;
  • 21
  • [ 14691-88-4 ]
  • [ 60835-75-8 ]
  • [ 1365104-18-2 ]
YieldReaction ConditionsOperation in experiment
82% With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 73h; Inert atmosphere;
  • 22
  • [ 60835-75-8 ]
  • [ 107993-90-8 ]
  • [ 1326775-41-0 ]
YieldReaction ConditionsOperation in experiment
74% With DMT-MM In tetrahydrofuran; water at 20℃; for 12h; 4-N-(5,6-heptadienyl)carbamoylbenzo-18-crown-6 (5) To a stirred solution of 4-ethoxycarbonylbenzo-18-crown-6 (26) (1.75 g, 4.94 mmol, 1.00 eq.) and 13 (1.65 g,14.8 mmol, 1.50 eq.) in THF (20.0 mL) and H2O (20.0 mL) was added DMT-MM (4.10 g, 14.8 mmol, 1.50 eq.) at room temperature. After being stirred at the same temperature for 12 h, the reaction mixture was concentrated in vacuo.The residue was purified by silica gel column chromatography with 95:5 CHCl3:MeOH to give 9 (3.29 g, 7.32 mmol,74%). Mp 83-85 °C; 1H NMR (400 MHz, CDCl3): δ 7.39 (d, 1H, J = 2.4 Hz), 7.24 (dd, 1H, J = 2.4, 8.7 Hz), 6.85 (d, 1H, J =8.7 Hz), 6.03 (br-t, 1H, J = 5.3 Hz), 5.10 (q, 1H, J = 6.8 Hz), 4.67 (dt, 2H, J = 3.4, 6.8 Hz), 4.21 (t, 2H, J = 4.8 Hz),4.19 (t, 2H, J = 4.4 Hz), 3.94 (t, 2H, J = 4.8 Hz), 3.92 (t, 2H, J = 4.4 Hz), 3.79-3.75 (m, 4H), 3.73-3.70 (m, 4H), 3.68 (s,4H), 3.43 (dt, 2H, J = 5.3, 6.8 Hz), 2.06 (dtt, 2H, Jk,l = Jl,m = 6.8 Hz, Jl,n = 3.4 Hz), 1.66 (tt, 2H, J = 6.8, 7.2 Hz), 1.51 (tt,2H, J = 7.2, 6.8 Hz); 13C NMR (100 MHz, CDCl3): δ 208.0, 167.0, 151.6, 148.7, 127.6, 120.0, 112.9, 112.4, 89.6, 74.9,70.8, 70.7, 70.6, 69.5, 69.4, 69.0, 68.9, 39.9, 29.1, 27.8, 26.3; FT-IR (KBr): 3274, 2914, 1954, 1640, 1507, 1265, 1121,958, 759 (cm-1); HRMS (ESI-TOF) calcd. for C24H39N2O7M+Na+ 467.2758, found 467.2757.
71% With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; for 0.666667h; 1.8 To a solution of 4-carboxybenzo-18-crown-6 (32.3 mg, 90.6 μmol, 1.00 eq.) and 1-amino-5,6-heptadiene (30.2 mg, 272 μmol, 3.00 eq.) in a dry methylene chloride solvent (1.00 mL), were added HATU (51.7 mg, 136 μmol, 1.50 eq.), diisopropylethylamine (23.4 μL, 136 μmol, 1.50 eq.), and a catalytic amount of N,N-dimethylaminopyridine at room temperature. The mixture is stirred at room temperature for 40 minutes, and the reaction solution is filtered. The resulting filtrate was concentrated, and the resulting residue was purified by silica gel column chromatography (eluent: chloroform:methanol=95:5) to obtain a crown ether allene monomer as shown below (39.3 mg, 64.3 μmol, 71%).
  • 23
  • [ 60835-75-8 ]
  • [ 927-74-2 ]
  • [ 1425377-23-6 ]
YieldReaction ConditionsOperation in experiment
89% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.4h;
  • 24
  • [ 60835-75-8 ]
  • [ 14235-81-5 ]
  • [ 1612796-67-4 ]
YieldReaction ConditionsOperation in experiment
79% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 48h; Inert atmosphere;
  • 25
  • [ 60835-75-8 ]
  • [ 2450-71-7 ]
  • C20H27NO7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% With DMT-MM In tetrahydrofuran; water at 20℃; for 24h; 4-(Prop-2-yn-1-ylcarbamoyl)-18-crown-6 (27) To a stirred solution of 26 (94.5 mg, 265 μmol, 1.00 eq.) and prop-2-yn-1-amine (37.0 μL, 530 μmol, 2.00eq.) in THF (1.00 mL) and H2O (1.00 mL) was added DMT-MM (110 mg, 398 μmol, 1.50 eq.) at room temperature. After being stirred at the same temperature for 24 h, the reaction mixture was concentrated in vacuo. The residue was purified by silica gel column chromatography with 95:5 CHCl3:MeOH to give 27 (75.5 mg, 194 μmol, 73%). 1H NMR (400 MHz, CDCl3): δ 7.44 (s, 1H), 7.31 (d, 1H, J = 7.7 Hz), 6.84 (d, 1H, J = 7.7 Hz), 6.45 (s, 1H), 4.24-4.22(m, 6H), 4.18 (br-s, 4H), 3.93 (t, 2H, J = 4.4 Hz), 3.93 (t, 2H, J = 4.4 Hz), 3.77-3.75 (m, 4H), 3.72-3.70 (m, 4H), 3.68 (s,4H), 2.27 (t, 1H, J = 2.4 Hz); 13C NMR (100 MHz, CDCl3): δ 166.6, 151.3, 148.1, 126.5, 120.4, 112.6, 112.0, 80.0, 77.3,71.3, 70.6, 70.5, 70.4, 70.3, 69.3, 69.2, 68.7, 68.5, 29.5; FT-IR (KBr): 3423, 3251, 2908, 1648, 1508, 1266, 1119, 957,733 (cm-1); HRMS (ESI-TOF) calcd. for C20H28NO7M+H+ 394.1866, found 394.1890
  • 26
  • [ 60835-75-8 ]
  • 10-(4-aminophenyl)-5,15-bis(2,4,6-trimethylphenyl)corrole [ No CAS ]
  • C60H61N5O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
82.2% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 48h; Corrole-linked crown ether (2). 4'-Carboxybenzo-18-crown-6 (89 mg, 0.25 mmol), compound 1 (156 mg, 0.25 mmol), (3-dimethylaminopropyl) ethylcarbodiimide monohydrochloride (EDCI, 72 mg,0.375 mmol), and 4,6-dimethyl-2-Pyridinamine (DMAP,15 mg, 0.125 mmol) were dissolved in dry CH2Cl2 (20 mL). The resulting mixture was stirred for 48 h at room temperature. Then, the reaction mixture was diluted with CH2Cl2 (100 mL) and washed with a 0.1 M aqueous HCl, saturated with NaHCO3 and brine, and dried over anhydrous MgSO4. After chromatographic purification (silica, first with CH2Cl2, then with CH2Cl2/MeOH 100 : 5), the corrole-crown ether (198 mg, 82.2% ) was obtained as a deep red solid. 1H NMR spectrum (400 M Hz, CDCl3, δ, ppm: -1.70 br.s (3H), 1.92 s (12H), 2.60 s (6H), 3.68 s (4H), 3.71 4H), 3.77 m (4H), 3.95 m (4H), 4.20 m (4H), 6.85 d (J =8.0 Hz, 1H), 7.54 d (J = 2.0 Hz, 1H), 7.65 d.d (J =8.0 Hz, J' = 2.0 Hz, 1H), 7.26 s (4H), 8.02 d (J =8.4 Hz, 2H), 8.14 d (J = 8.0 Hz, 2H), 8.31 d (J =4.0 Hz, 2H), 8.47 d (J = 4.8 Hz, 2H), 8.51 d (J =4.8 Hz, 2H), 8.87 d (J = 4.0 Hz, 2H); MS (MALDI-TOF):963.4 [M]+, 986.4 [M + Na]+, 1002.4 [M + K]+; λabs (toluene, ε × 10-3): 410 (69.4), 429 (55.9), 567(9.1), 606 (6.5), 639 (4.6).
  • 27
  • [ 179091-70-4 ]
  • [ 60835-75-8 ]
  • C34H50N2O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 20h;
  • 28
  • [ 60835-75-8 ]
  • C14H30N2O [ No CAS ]
  • C31H52N2O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 20h;
  • 29
  • [ 60835-75-8 ]
  • C13H28N2O [ No CAS ]
  • C30H50N2O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 20h;
  • 30
  • [ 60835-75-8 ]
  • [ 84004-98-8 ]
  • C31H52N2O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 20h;
  • 31
  • [ 60835-75-8 ]
  • (S)-2-amino-N-octylpropanamide [ No CAS ]
  • C28H46N2O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 20h;
  • 32
  • [ 60835-75-8 ]
  • [ 97515-33-8 ]
  • C27H44N2O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 20h;
  • 33
  • [ 60835-75-8 ]
  • C24H39NO5 [ No CAS ]
  • C45H69NO12 [ No CAS ]
YieldReaction ConditionsOperation in experiment
10% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;
  • 34
  • [ 60835-75-8 ]
  • C26H43NO5 [ No CAS ]
  • C47H73NO12 [ No CAS ]
YieldReaction ConditionsOperation in experiment
12% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;
  • 35
  • [ 60835-75-8 ]
  • tetradecyl N-(tert-butoxycarbonyl)-L-tyrosinate [ No CAS ]
  • C49H77NO12 [ No CAS ]
YieldReaction ConditionsOperation in experiment
31% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;
  • 36
  • [ 14098-24-9 ]
  • [ 76-05-1 ]
  • [ 60835-75-8 ]
  • 37
  • 4,4-difluoro-1,3,5,7-tetramethyl-8-(4-hydroxyphenyl)-4-bora-3a,4a-diaza-s-indacene [ No CAS ]
  • [ 60835-75-8 ]
  • C53H63BF2N2O13 [ No CAS ]
YieldReaction ConditionsOperation in experiment
46.7% With piperidine; acetic acid In benzene for 48h; Dean-Stark; Reflux;
  • 38
  • [ 60835-75-8 ]
  • [ 221002-03-5 ]
  • C42H56O16 [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h; Inert atmosphere;
  • 39
  • [ 60835-75-8 ]
  • [ 155130-15-7 ]
  • C34H50O15S [ No CAS ]
  • 40
  • [ 60835-75-8 ]
  • [ 4549-32-0 ]
  • C25H39BrO8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate In acetonitrile at 85℃; for 12h;
  • 41
  • [ 60835-75-8 ]
  • [ 4101-68-2 ]
  • C27H43BrO8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate In acetonitrile at 85℃; for 12h;
  • 42
  • [ 60835-75-8 ]
  • [ 3344-70-5 ]
  • C29H47BrO8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate In acetonitrile at 85℃; for 12h;
  • 43
  • [ 60835-75-8 ]
  • [ 37688-96-3 ]
  • C31H51BrO8 [ No CAS ]
  • 44
  • [ 60835-75-8 ]
  • [ 106-93-4 ]
  • C19H27BrO8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate In acetonitrile at 85℃; for 12h;
  • 45
  • [ 60835-75-8 ]
  • [ 106-96-7 ]
  • C20H26O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% With potassium carbonate In acetonitrile at 85℃; Darkness;
  • 46
  • [ 60835-75-8 ]
  • [ 132139-11-8 ]
  • C38H58N2O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 24h;
With benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate; N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 20h;
  • 47
  • [ 60835-75-8 ]
  • C15H32N2O [ No CAS ]
  • C32H54N2O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 24h;
  • 48
  • [ 60835-75-8 ]
  • [ 852331-99-8 ]
  • C36H54N2O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 24h;
  • 49
  • [ 60835-75-8 ]
  • 4-benzyl alcohol-24-crown-8 [ No CAS ]
  • C42H56O16 [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;
  • 50
  • [ 60835-75-8 ]
  • [ 17643-36-6 ]
  • C27H40O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% Stage #1: 4’-carboxybenzo-18-crown-6; dec-9-yn-1-ol With 4-dimethylaminopyridine In dichloromethane at 0℃; for 0.166667h; Stage #2: With N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 36h;
  • 51
  • [ 60835-75-8 ]
  • [ 17643-36-6 ]
  • C62H66N6O8S [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: 4-dimethylaminopyridine / dichloromethane / 0.17 h / 0 °C 1.2: 36 h / 0 - 20 °C 2.1: Cupric sulfate; sodium ascorbate powder / N,N-dimethyl-formamide / 12 h / 20 °C / Sealed tube
Same Skeleton Products
Historical Records