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Chemical Structure| 610276-37-4 Chemical Structure| 610276-37-4

Structure of 610276-37-4

Chemical Structure| 610276-37-4

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Product Details of [ 610276-37-4 ]

CAS No. :610276-37-4
Formula : C14H8ClFN2
M.W : 258.68
SMILES Code : FC1=CC=CC=C1C2=NC(Cl)=C3C=CC=CC3=N2
MDL No. :MFCD03030427

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Application In Synthesis of [ 610276-37-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 610276-37-4 ]

[ 610276-37-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 271-34-1 ]
  • [ 610276-37-4 ]
  • 2-(2-fluoro-phenyl)-4-pyrrolo[3,2-c]pyridin-1-yl-quinazoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 100℃; for 0.5h; 4-CHLORO-2- (2-FLUORO-PHENYL)-QUINAZOLINE from Step C (0. LG, 0.38mmol) was dissolved in N, N- , DIMETHYLFORMAMIDE (1ML) and to it was added lH-pyrrolo [3,2- c] pyridine (0.046g, 0.38mmol) followed by cesium carbonate (0.134g, 0.41mmol). The mixture was magnetically stirred and heated TOLO0C for 0.5hr. The solvent was removed and title compound was obtained pure after column purification on a HPLC reverse phase column, using a water and acetonitrile gradient containing 0. 1% trifluoroacetic acid to yield (0.072g, 56%). MS (ES) 340.1 (M+H) +
 

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