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Chemical Structure| 61128-73-2 Chemical Structure| 61128-73-2

Structure of 61128-73-2

Chemical Structure| 61128-73-2

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Product Details of [ 61128-73-2 ]

CAS No. :61128-73-2
Formula : C5H9NO2
M.W : 115.13
SMILES Code : O/N=C1CCOCC\1
MDL No. :MFCD09998842
InChI Key :COGGGWRHZQTITF-UHFFFAOYSA-N
Pubchem ID :12298558

Safety of [ 61128-73-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H228-H302-H317-H319-H341-H351
Precautionary Statements:P280-P210-P240-P264-P270-P301+P310-P330-P370+P378-P403+P233-P405-P501
Class:4.1
UN#:1325
Packing Group:

Application In Synthesis of [ 61128-73-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 61128-73-2 ]

[ 61128-73-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 61128-73-2 ]
  • aluminum nickel [ No CAS ]
  • [ 33024-60-1 ]
YieldReaction ConditionsOperation in experiment
89% With hydrogenchloride; In 1,4-dioxane; methanol; ethanol; Step 2. Preparation of perhydro-2H-pyran-4-ylamine Hydrochloride. A mixture of 4-(hydroxyimino)-3,5,6-trihydro-2H-pyran (43.4 mmol) and Raney Nickel (200 mg) in ethanol was hydrogenated (90 psi) at room temperature for 3 days. The mixture was filtered through a pad of Celite, washed with MeOH, and concentrated. The residue was dissolved in MeOH, and treated with HCl (4 N in dioxane, 60 mmol), and concentrated to give perhydro-2H-pyran-4-ylamine hydrochloride (89percent).
  • 2
  • [ 61128-73-2 ]
  • [ 33024-60-1 ]
YieldReaction ConditionsOperation in experiment
Example A: Synthesis of tetrahydro-4H-pyran-4-amine hydrochloride Step a: Tetrahydro-4H-pyran-4-one oxime; To a solution of tetrahydro-4H-pyran-4-one (commercially available) (20 g, 200 mmol) in ethanol (300 mL) was added hydroxylamine hydrochloride (41.7 g, 600 mmol). An aqueous solution of sodium acetate (57.4. g, 700 mmol) was added into the reaction mixture at 40- 50 0C and refluxed overnight. The reaction mixture was concentrated under reduced pressure and the residue thus obtained was then extracted with ethyl acetate. The combined organic layer was then washed with water, dried over anhydrous sodium sulphate, filtered and evaporated under reduced pressure to yield the title compound. Yield = 17 g.
 

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