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Chemical Structure| 6137-75-3 Chemical Structure| 6137-75-3

Structure of 6137-75-3

Chemical Structure| 6137-75-3

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Product Details of [ 6137-75-3 ]

CAS No. :6137-75-3
Formula : C7H10O2
M.W : 126.15
SMILES Code : CC(O)(C1=COC=C1)C

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Application In Synthesis of [ 6137-75-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6137-75-3 ]

[ 6137-75-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6137-75-3 ]
  • [ 67442-07-3 ]
  • ammonium chloride [ No CAS ]
  • methyl[6-chloro-2-[3-(1-hydroxy-1-methylethyl)-2-furoyl]-1H-indol-3-yl]acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.03 g (32%) With n-butyllithium; In tetrahydrofuran; hexane; To a solution of 2-(3-furyl)-2-propanol (T. M. Bargar et al., J. Med. Chem., 1986, 29, 315., 2.0 g, 15.85 mmol) in THF (100 ml) was added a solution of n-butyllithium in hexane (1.55M, 30.7 ml, 47.55 mmol) at -78° C. After stirring for 1 h, <strong>[67442-07-3]2-chloro-N-methoxy-N-methylacetamide</strong> (6.54 g, 47.55 mmol) was added at 0° C. Saturated aqueous ammonium chloride (100 ml) was added to the mixture and the organic layer was separated. The organic layer was washed with water (100 ml*2) and brine (50 ml) and dried (MgSO4). After removal of the solvent, the residue was purified by flash chromatography eluding with ethyl acetate/hexane (1:4) to afford 1.03 g (32percent) of the title compound as an oil. 1H-NMR (CDCl3) delta: 7.52 (1H, d, J=1.8 Hz), 6.56 (1H, d, J=1.8 Hz), 5.51 (1H, s), 4.74 (2H, s), 1.56 (6H, s).
 

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