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Chemical Structure| 614-27-7 Chemical Structure| 614-27-7

Structure of 614-27-7

Chemical Structure| 614-27-7

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Product Details of [ 614-27-7 ]

CAS No. :614-27-7
Formula : C10H10O3
M.W : 178.18
SMILES Code : O=C(OC)CC(C1=CC=CC=C1)=O
MDL No. :MFCD00957180
Boiling Point : No data available
InChI Key :WRGLZAJBHUOPFO-UHFFFAOYSA-N
Pubchem ID :348462

Safety of [ 614-27-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 614-27-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 614-27-7 ]
  • Downstream synthetic route of [ 614-27-7 ]

[ 614-27-7 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 614-27-7 ]
  • [ 113-00-8 ]
  • [ 56741-94-7 ]
YieldReaction ConditionsOperation in experiment
800 mg With sodium methylate In methanol at 65℃; Inert atmosphere A mixture of methyl 3-oxo-3-phenylpropanoate (2.0 g) , guanidine (2.02 g) and sodium methanolate (1.12 g) in methanol (50 mL) was stirred at 65°C overnight under a nitrogen atmosphere. The reaction mixture was evaporated under reduced pressure. The residue was purified by washed with methanol: ethyl acetate (1:10) as eluent to give the desired compound (800 mg) as a white solid. LC-MS m/z [M+H]+ = 188 (calc=188) (ES+)
References: [1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 5, p. 1315 - 1321.
 

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