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[ CAS No. 6142-05-8 ]

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2D
Chemical Structure| 6142-05-8
Chemical Structure| 6142-05-8
Structure of 6142-05-8 *Storage: {[proInfo.prStorage]}

Quality Control of [ 6142-05-8 ]

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Related Doc. of [ 6142-05-8 ]

SDS

Product Details of [ 6142-05-8 ]

CAS No. :6142-05-8MDL No. :MFCD00270826
Formula :C3H5ClN2SBoiling Point :-
Linear Structure Formula :-InChI Key :N/A
M.W :136.60Pubchem ID :80239
Synonyms :

Computed Properties of [ 6142-05-8 ]

TPSA : 67.2 H-Bond Acceptor Count : 3
XLogP3 : - H-Bond Donor Count : 2
SP3 : 0.00 Rotatable Bond Count : 0

Safety of [ 6142-05-8 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305 P351 P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 6142-05-8 ]

  • Downstream synthetic route of [ 6142-05-8 ]

[ 6142-05-8 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 6142-05-8 ]
  • [ 473807-32-8 ]
  • 3-methyl-5-[1-(thiazol-2-yl)pyridin-4(1H)-ylidene]-2-thioxo-1,3-thiazolidin-4-one [ No CAS ]
  • 2
  • [ 96-50-4 ]
  • [ 6142-05-8 ]
  • [ 89533-52-8 ]
  • 3
  • [ 1793-07-3 ]
  • [ 6142-05-8 ]
  • 2-(Thiazol-2-ylamino)-benzo[d][1,3]oxazin-4-one [ No CAS ]
  • 4
  • [ 7791-25-5 ]
  • [ 1189-71-5 ]
  • [ 6142-05-8 ]
  • boc-sulfonylurea [ No CAS ]
YieldReaction ConditionsOperation in experiment
In pyridine; tert-butyl alcohol; Step 1 To a solution of chlorosulfonylisocyanate (1.35 g, 9.6 mmol) in DCM (50 mL) at 0 C., is added t-BuOH (918 uL, 9.6 mmol) and stirred for 30 min while maintaining temperature at 0 C. To a solution of amine 22 (820 mg, 0.72 mmol) in pyridine (12 mL) is added 0.2 M solution of sulfonyl chloride (1.44 mmol, 0.72 mL). The reaction is stirred for 5 min at 0 C. The solvents were evaporated in vacuo and the solid is purified by basic alumina flash chromatography (gradient elution: 0-10% MeOH/DCM to provide 220 mg of the boc-sulfonylurea. MS (M+H)+1317.
YieldReaction ConditionsOperation in experiment
With nitrogen; Example 13 Preparation of Aminothiazole hydrochloric acid (22) Hydrochloric acid is bubbled through a solution of Boc protected amine (4, 1.4 g, 1.1 mmol) in DCM (20 mL) for thirty min. The reaction mixture is then tightly capped and stirred for thirty minutes after which the reaction mixture is sparged with nitrogen. The mixture loses its gel like appearance. DCM (5 mL) is added to the solution, and HCl gas is bubbled through it for an additional 20 min, followed by nitrogen for 30 min. Crude product (1.32 g) is obtained after concentration as a bright orange solid, and taken on to the next step with no further purification. LCMS: Rt=1.5 min, [M+H]+ 1138.
  • 6
  • [ 1161733-88-5 ]
  • [ 6142-05-8 ]
  • [ 1397715-50-2 ]
  • 7
  • [ 1046150-80-4 ]
  • [ 6142-05-8 ]
  • [ 745053-71-8 ]
  • 8
  • [ 1046150-82-6 ]
  • [ 6142-05-8 ]
  • [ 1046150-85-9 ]
  • 9
  • [ 745053-46-7 ]
  • [ 6142-05-8 ]
  • [ 745051-60-9 ]
  • 10
  • [ 1023277-63-5 ]
  • [ 6142-05-8 ]
  • [ 1023276-51-8 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In methanol; at 110℃; for 48h; Example 58 8-indan-5-yl-5-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid thiazol-2-ylamide (Cpd 131) A solution of 8-indan-5-yl-5-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid methyl ester (10 mg) and <strong>[6142-05-8]thiazol-2-ylamine hydrochloride</strong> (20 mg) in 1:1 TEA and MeOH (2 mL) was heated in a sealed tube at 110 C. for 2 days. After cooling, water was added and the solution was directly purified (HPLC, C-18 YMC ODS-A 5mu 30*100 mm, 120 A column at 32 mL/min, 5-100% H2O/MeCN (0.1% TFA v/v) gradient over 10 min.) to provide the title compound (2.5 mg). 1H NMR (TFA salt) (400 MHz, CDCl3) delta (ppm): 9.46 (s, 1H), 8.92 (s, 1H), 7.44-7.35 (m, 3H), 7.30-7.23 (m, 4H), 7.13-7.06 (m, 2H), 3.83 (m, 5H), 3.22-3.13 (m, 2H), 3.01-3.07 (m, 4H), 2.78-2.53 (m, 6H), 2.16-2.20 (m, 4H); Mass Spectrum (LCMS, APCI pos.) Calcd. For: C32H31N7O2S: 577.23; Found: 578.2 (M+H).
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