[ CAS No. 6142-06-9 ]

Name: 6142-06-9|N-Methyl-2-thiazolamine|95%
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Quality Control of [ 6142-06-9 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 6142-06-9 ]

CAS No. :	6142-06-9	MDL No. :	MFCD09966061
Formula :	C₄H₆N₂S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	DWVCPSQPTSNMRX-UHFFFAOYSA-N
M.W :	114.17 g/mol	Pubchem ID :	11959081
Synonyms :

Calculated chemistry of [ 6142-06-9 ]

Physicochemical Properties

Num. heavy atoms :	7
Num. arom. heavy atoms :	5
Fraction Csp3 :	0.25
Num. rotatable bonds :	1
Num. H-bond acceptors :	1.0
Num. H-bond donors :	1.0
Molar Refractivity :	31.42
TPSA :	53.16 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.46 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.47
Log Po/w (XLOGP3) :	0.75
Log Po/w (WLOGP) :	0.99
Log Po/w (MLOGP) :	-0.2
Log Po/w (SILICOS-IT) :	1.84
Consensus Log Po/w :	0.97

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.48
Solubility :	3.76 mg/ml ; 0.0329 mol/l
Class :	Very soluble
Log S (Ali) :	-1.45
Solubility :	4.09 mg/ml ; 0.0358 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.68
Solubility :	2.41 mg/ml ; 0.0211 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.19

Safety of [ 6142-06-9 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 6142-06-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 6142-06-9 ]
Downstream synthetic route of [ 6142-06-9 ]

[ 6142-06-9 ] Synthesis Path-Upstream 1~6

1
[ 3034-53-5 ]
[ 74-89-5 ]
[ 6142-06-9 ]

Yield	Reaction Conditions	Operation in experiment
67%	at 120℃; for 2 h;	Synthesis of Exemplary Compound 14: N-Methyl-N-(2-(methyl(thiazol-2-yl)amino)-2-oxoethyl)-3-phenylpropiolamide; a) Synthesis of N-methylthiazol-2-amine; 900 μl (10 mmol) of 2-bromothiazole were heated together with a 33percent strength ethanolic methylamine soln. (70 ml) in an autoclave (to approx. 120° C.) until a pressure of 10 bar had developed. The mixture was stirred for 2 h under these conditions. The reaction mixture was then evaporated under a vacuum and the residue was redissolved in a 3percent strength aq. HCl soln. and washed with ether, after which the pH was adjusted to 12 with a 20percent strength aq. NaOH soln. The solution was saturated with NaCl and extracted with chloroform. The organic phase was dried over MgSO₄, filtered and evaporated under a vacuum, 761 mg (6.7 mmol, 67percent) of N-methylthiazol-2-amine being obtained.

Reference： [1] Patent: US2009/176756, 2009, A1, . Location in patent: Page/Page column 50

2
[ 25602-39-5 ]
[ 6142-06-9 ]

Reference： [1] Synthetic Communications, 2001, vol. 31, # 19, p. 2921 - 2927
[2] Patent: US5849769, 1998, A,

3
[ 78508-29-9 ]
[ 6142-06-9 ]

Reference： [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 1569 - 1573

4
[ 598-52-7 ]
[ 43696-08-8 ]
[ 6142-06-9 ]

Reference： [1] European Journal of Medicinal Chemistry, 1986, vol. 21, # 1, p. 59 - 64

5
[ 10140-87-1 ]
[ 598-52-7 ]
[ 6142-06-9 ]

Reference： [1] Yakugaku Kenkyu, 1953, vol. 25, p. 678,680, 681[2] Chem.Abstr., 1955, p. 1013

6
[ 623-46-1 ]
[ 598-52-7 ]
[ 6142-06-9 ]

Reference： [1] Justus Liebigs Annalen der Chemie, 1891, vol. 265, p. 113

[ 6142-06-9 ] Synthesis Path-Downstream 1~33

1
[ 6142-06-9 ]
[ 121347-21-5 ]
4-(toluene-4-sulfonyloxy)-benzenesulfonic acid-(methyl-thiazol-2-yl-amide) [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1951,vol. 73,p. 2558,2560

2
[ 6142-06-9 ]
[ 98-74-8 ]
[ 858500-74-0 ]

Reference： [1]Helvetica Chimica Acta,1941,vol. 24,p. 536

3
[ 6142-06-9 ]
[ 121-60-8 ]
[ 66507-95-7 ]

Reference： [1]Dansk Tidsskrift for Farmaci,1941,vol. 15,p. 41,70

4
[ 10140-87-1 ]
[ 598-52-7 ]
[ 6142-06-9 ]

Reference： [1]Yakugaku Kenkyu,1953,vol. 25,p. 678,680, 681
Chem.Abstr.,1955,p. 1013

5
[ 623-46-1 ]
[ 598-52-7 ]
[ 6142-06-9 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1891,vol. 265,p. 113

6
[ 17118-70-6 ]
[ 6142-06-9 ]
[ 73384-51-7 ]

Reference： [1]Journal of Organic Chemistry,1980,vol. 45,p. 2474 - 2479

7
[ 6142-06-9 ]
[ 15781-70-1 ]
anhydro-(8-methyl-5-hydroxy-7-oxothiazolo<3,2-a>pyrimidinium hydroxide) [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,1985,vol. 22,p. 465 - 474
[2]Journal of Medicinal Chemistry,1981,vol. 24,p. 1284 - 1287

8
[ 6142-06-9 ]
[ 28439-86-3 ]
3-(4-Butoxy-phenyl)-1-methyl-1-thiazol-2-yl-urea [ No CAS ]

Reference： [1]European Journal of Medicinal Chemistry,1986,vol. 21,p. 59 - 64

9
[ 6142-06-9 ]
[ 15781-72-3 ]
C₉H₁₀N₂O₂S [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 1284 - 1287

10
[ 6142-06-9 ]
[ 15781-71-2 ]
anhydro(5-hydroxy-6,8-dimethyl-7-oxothiazolo<3,2-a>pyrimidinium hydroxide) [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 1284 - 1287

11
[ 6142-06-9 ]
[ 100-28-7 ]
[ 102269-22-7 ]

Reference： [1]European Journal of Medicinal Chemistry,1986,vol. 21,p. 59 - 64

12
[ 6142-06-9 ]
[ 98-88-4 ]
[ 118215-02-4 ]

Reference： [1]Chemistry of Heterocyclic Compounds,1988,p. 337 - 344
Khimiya Geterotsiklicheskikh Soedinenii,1988,vol. 24,p. 410 - 417

13
[ 6142-06-9 ]
[ 102-36-3 ]
[ 102269-20-5 ]

Reference： [1]European Journal of Medicinal Chemistry,1986,vol. 21,p. 59 - 64

14
[ 6142-06-9 ]
[ 407-25-0 ]
[ 118215-01-3 ]

Reference： [1]Chemistry of Heterocyclic Compounds,1988,p. 337 - 344
Khimiya Geterotsiklicheskikh Soedinenii,1988,vol. 24,p. 410 - 417

15
[ 598-52-7 ]
[ 43696-08-8 ]
[ 6142-06-9 ]

Reference： [1]European Journal of Medicinal Chemistry,1986,vol. 21,p. 59 - 64

16
[ 78508-29-9 ]
[ 6142-06-9 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1981,p. 1569 - 1573

18
[ 7732-18-5 ]
[ 598-52-7 ]
α.β-dichloro ether [ No CAS ]
[ 6142-06-9 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1891,vol. 265,p. 113

19
[ 6142-06-9 ]
[ 59024-02-1 ]

Reference： [1]Synthetic Communications,2001,vol. 31,p. 2921 - 2927
[2]Acta Crystallographica, Section C: Crystal Structure Communications,2004,vol. 60,p. o627-o629

20
[ 25602-39-5 ]
[ 6142-06-9 ]

Yield	Reaction Conditions	Operation in experiment
	In tetrahydrofuran;	2-formamidothiazole (1.6 g, 14 mmolee) was dissolved in dry tetrahydrofuran. To the solution was added aluminium hydride (0.8 g, 21 mmolee). The reaction mixture was refluxed for 3 hrs, and poured onto ice. It was extracted with dichloromethane three times, and the organic solution was washed with water and evaporated. 2-methylaminothiazole was isolated by alumina column chromatography.

Reference： [1]Synthetic Communications,2001,vol. 31,p. 2921 - 2927
[2]Patent: US5849769,1998,A

21
[ 6142-06-9 ]
[ 98-98-6 ]
pyridine-2-carboxylic acid methyl-thiazol-2-yl-amide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 635 - 638

22
[ 6142-06-9 ]
[ 169457-73-2 ]
[ 856418-71-8 ]

Yield	Reaction Conditions	Operation in experiment
22%	With potassium iodide; In N,N-dimethyl-formamide; at 80℃; for 12h;	133a) tert-butyl 4-(2-((2Z)-2-(methylimino)-1,3-thiazol-3(2H)-yl)ethyl)-1-piperidinecarboxylate To a solution of tert-butyl 4-(2-bromoethyl)-1-piperidinecarboxylate (D. Brundish et al., J. Med. Chem., 42, 4584 (1999); 5.0 g) and <strong>[6142-06-9]2-methylaminothiazole</strong> (O. Kemal et al., J. Chem. Soc. Perkin I, 5, 1569 (1981); 3.9 g) in DMF (50 ml) was added potassium iodide (5.7 g), and mixed at 80C for 12 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in chloroform and a saturated aqueous potassium hydrogen carbonate solution. The organic layer was collected by separation, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was purified with silica gel column to obtain the title compound as a brown oil (1.25 g, 22%). NMR (CDCl3) delta: 1.06-1.21 (2H, m), 1.45 (9H, s), 1.47 (1H, m), 1.58-1.69 (4H, m), 2.59-2.74 (2H, m), 2.97 (3H, s), 3.75 (2H, t, J=7.4), 4.00-4.16 (2H, br), 5.90 (1H, d, J=4.9), 6.51 (1H, d, J=4.9).

Reference： [1]Patent: EP1695961,2006,A1 .Location in patent: Page/Page column 125

23
[ 6142-06-9 ]
[ 13734-36-6 ]
[ 943429-96-7 ]

Yield	Reaction Conditions	Operation in experiment
21%	With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20℃; for 32h;	b) Synthesis of tert.-butyl methyl(2-(methyl(thiazol-2-yl)amino)-2-oxoethyl)carbamate; 871 mul (5.0 mmol) of diisopropylethylamine, 571 mg (5.0 mmol) of <strong>[6142-06-9]N-methylthiazol-2-amine</strong> and 1.60 g (5.0 mmol) of TBTU were added to a solution of 946 mg (5.0 mmol) of Boc-sarcosine in MeCN (11 ml) and the reaction mixture was stirred at RT for 16 h. A further 284 mg (1.5 mmol) of Boc-sarcosine, 216 mul (1.5 mmol) of diisopropylethylamine, 5 ml of MeCN and 1.60 g (5.0 mmol) of TBTU were added thereto and the reaction mixture was stirred at RT for a further 16 h. After removal of the solvent under a vacuum the residue was redissolved in chloroform, washed with water and sat. aq. NaCl soln. and dried over MgSO4. After filtration and evaporation under a vacuum, column chromatography (SiO2, chloroform) was carried out with the residue, 300 mg (1.05 mmol, 21%) of tert.-butyl methyl(2-(methyl(thiazol-2-yl)amino)-2-oxoethyl)carbamate being obtained.

Reference： [1]Patent: US2009/176756,2009,A1 .Location in patent: Page/Page column 50-51

24
[ 3034-53-5 ]
[ 74-89-5 ]
[ 6142-06-9 ]

Yield	Reaction Conditions	Operation in experiment
67%	In ethanol; at 120℃; under 7500.75 Torr; for 2h;	Synthesis of Exemplary Compound 14: N-Methyl-N-(2-(methyl(thiazol-2-yl)amino)-2-oxoethyl)-3-phenylpropiolamide; a) Synthesis of N-methylthiazol-2-amine; 900 mul (10 mmol) of 2-bromothiazole were heated together with a 33% strength ethanolic methylamine soln. (70 ml) in an autoclave (to approx. 120 C.) until a pressure of 10 bar had developed. The mixture was stirred for 2 h under these conditions. The reaction mixture was then evaporated under a vacuum and the residue was redissolved in a 3% strength aq. HCl soln. and washed with ether, after which the pH was adjusted to 12 with a 20% strength aq. NaOH soln. The solution was saturated with NaCl and extracted with chloroform. The organic phase was dried over MgSO4, filtered and evaporated under a vacuum, 761 mg (6.7 mmol, 67%) of N-methylthiazol-2-amine being obtained.

Reference： [1]Patent: US2009/176756,2009,A1 .Location in patent: Page/Page column 50

25
[ 6142-06-9 ]
[ 55332-38-2 ]
[ 1208552-53-7 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 493 - 498

26
[ 6142-06-9 ]
[ 1033591-79-5 ]
[ 1223596-27-7 ]

Reference： [1]Synthesis,2010,p. 979 - 984

27
[ 6142-06-9 ]
[ 929973-34-2 ]
[ 1223466-25-8 ]

Reference： [1]Synthesis,2010,p. 979 - 984

28
[ 6142-06-9 ]
[ 1033591-80-8 ]
[ 1228593-74-5 ]

Reference： [1]Synthesis,2010,p. 979 - 984

29
[ 6142-06-9 ]
[ 69812-51-7 ]
[ 1392467-10-5 ]

Yield	Reaction Conditions	Operation in experiment
79.2%	With triethylamine; In 1,2-dichloro-ethane; at 100℃; for 20.5h;	To methyl 4-chlorosulfonylbenzoate (4 g, 17.05 mmol), <strong>[6142-06-9]N-methylthiazol-2-amine</strong> (1.95 g, 17.05 mmol), 1,2-dichloroethane (20 mL), and triethylamine (2.38 mL, 17.05 mmol) were added and the reaction was heated at 100 C. in a pressure vessel for 20.5 hours on a heat block. The solvent was evaporated under reduced pressure. The crude compound was dissolved in dichloromethane and filtered. The filtrate was purified by silica gel chromatography utilizing a gradient of 0-30% ethyl acetate in dichloromethane to yield methyl 4-[methyl(thiazol-2-yl)sulfamoyl]benzoate (4.22 g, 79.2%). 1H NMR (400 MHz, DMSO) delta 8.16 (d, J=8.5 Hz, 2H), 7.95 (d, J=8.5 Hz, 2H), 7.46 (d, J=3.6 Hz, 1H), 7.44 (d, J=3.6 Hz, 1H), 3.89 (s, 3H), 3.39 (s, 3H). ESI-MS m/z calc. 312.0. found 313.3 (M+1) +; Retention time: 1.52 minutes (3 min run).

Reference： [1]Patent: US2012/196869,2012,A1 .Location in patent: Paragraph 0426; 0427

30
[ 6142-06-9 ]
[ 496-41-3 ]
N-methyl-N-(thiazol-2-yl)benzofuran-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With N-ethyl-N,N-diisopropylamine; HATU; In ethyl acetate; N,N-dimethyl-formamide; at 0 - 20℃; for 24.5h;Inert atmosphere;	Example 2 N-methyl-N-(thiazol-2-yl)benzofuran-2-carboxamide [0287] benzofuran-2-carboxylic acid (30 mg, 0.17 mmol) and <strong>[6142-06-9]N-methyl-2-thiazolamine</strong> (24.3 mg, 0.213 mmol) in DMF (1 mL) at 0 C. was added HATU (80.8 mg, 0.213 mmol), followed by addition of DIEA (63.8 mul, 0.366 mmol). After stirring under argon at 0 C. for 0.5 hours and at room temperature over 24 hours, the reaction mixture was taken up in EtOAc (10 mL) and 0.1 N HCl (10 mL). The organic layers were washed with 0.1 N NaOH (10 mL), brine (5 mL), dried (Na2SO4) and concentrated in vacuo. The resulting solid was chromatographed on silica gel with 5% and 10% EtOAc/hexane to give the target molecule as a white solid (38 mg, 82%).

Reference： [1]Patent: US2015/126507,2015,A1 .Location in patent: Paragraph 0287-0288

31
[ 6142-06-9 ]
[ 24673-56-1 ]
N,3-dimethyl-N-(thiazol-2-yl)benzofuran-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20℃; for 24.5h;Inert atmosphere;	Example 1 N,3-dimethyl-N-(thiazol-2-yl)benzofuran-2-carboxamide [0285] 3-methylbenzofuran-2-carboxylic acid (30 mg, 0.17 mmol) and N-methyl-2-thiazolamine (24.3 mg, 0.213 mmol) in DMF (1 mL) at 0 C. was added HATU (80.8 mg, 0.213 mmol), followed by addition of DIEA (63.8 mul, 0.366 mmol). After stirring under argon at 0 C. for 0.5 hours and at room temperature over 24 hours, the reaction mixture was taken up in EtOAc (10 mL) and 0.1 N HCl (10 mL). The organic layers were washed with 0.1 N NaOH (10 mL), brine (5 mL), dried (Na2SO4) and concentrated in vacuo. The resulting solid was chromatographed on silica gel with 5% and 10% EtOAc/hexane to give the target molecule as a white solid (38 mg, 82%).

Reference： [1]Patent: US2015/126507,2015,A1 .Location in patent: Paragraph 0285-0286

32
[ 6142-06-9 ]
methyl (2S)-1-[4-[(3-cyclopentyl-1H-pyrazol-5-yl)amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]pyrrolidine-2-carboxylate [ No CAS ]
(2S)-1-[4-[(3-cyclopentyl-1H-pyrazol-5-yl)amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]-N-methyl-N-thiazol-2-yl-pyrrolidine-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
6 mg		Example 7. Preparation of Compound Nos. 70. 70a and 70b To a solution of<strong>[6142-06-9]N-methylthiazol-2-amine</strong> (115.1 mg, 1.01 mmol) in THF (3 mL) was added isopropyl magnesium chloride (2 M) in THF (0.5 mL, 1.10 mmol) dropwise at 0 C and the resultant mixture was allowed to stir at the same temperature for 30 min. To this reaction mixture a solution of methyl (2S)-l-[4-[(3-cyclopentyl-lH-pyrazol-5-yl)amino]-6,7- dihydro 5H-cyclopenta[d]pyrimidin-2-yl]pyrrolidine-2-carboxylate (100 mg, 0.25 mmol) in THF (1 mL) was added dropwise. The reaction mixture was allowed to stir at RT for 16 h. The reaction was quenched with saturated ammonium chloride solution (2 mL) and extracted with EtOAc (2x20 mL). The combined organic layers were washed with brine (20 mL) and dried over anhydrous sodium sulfate. Concentration under reduced pressure gave a solid crude product that was purified by reverse phase HPLC to afford 6 mg of (2S)-l-[4-[(3- cyclopentyl-lH-pyrazol-5-yl)arm^o]-6,7-dihydro-5H-cyclopenta[d]pyrirnidin-2-yl]-N- methyl-N-thiazol-2-yl-pyrrolidine-2-carboxamide (Compound No. 70b). 1H NMR (CDCl3, 400 MHz) 1.42-1.82 (m, 4H), 1.90-2.42 (m, 7H), 2.50-3.20 (m, 6H), 3.87-4.02 (m, 6H), 5.22 (d, 1H), 6.20 (brs, 1H), 6.66 (brs, 1H), 6.98 (d, 1H), 7.51 (d, 1H).

Reference： [1]Patent: WO2016/3827,2016,A2 .Location in patent: Paragraph 0183

33
[ 6142-06-9 ]
4-(chlorosulfonyl)benzenesulfonyl fluoride [ No CAS ]
C₁₀H₉FN₂O₄S₃ [ No CAS ]

Reference： [1]ACS Combinatorial Science,2018,vol. 20,p. 672 - 680

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Code	Phrase
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P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 6142-06-9 ]

Quality Control of [ 6142-06-9 ]

Related Doc. of [ 6142-06-9 ]

Product Details of [ 6142-06-9 ]

Calculated chemistry of [ 6142-06-9 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 6142-06-9 ]

Application In Synthesis of [ 6142-06-9 ]

[ 6142-06-9 ] Synthesis Path-Upstream 1~6

[ 6142-06-9 ] Synthesis Path-Downstream 1~33

Related Functional Groups of [ 6142-06-9 ]

Amines

Related Parent Nucleus of [ 6142-06-9 ]

Thiazoles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 6142-06-9 ]

Related Parent Nucleus of
[ 6142-06-9 ]