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Chemical Structure| 61435-75-4 Chemical Structure| 61435-75-4

Structure of 61435-75-4

Chemical Structure| 61435-75-4

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Product Details of [ 61435-75-4 ]

CAS No. :61435-75-4
Formula : C8H14ClNO3
M.W : 207.65
SMILES Code : O=C(O)CCCCCNC(CCl)=O

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Application In Synthesis of [ 61435-75-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 61435-75-4 ]

[ 61435-75-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 61435-75-4 ]
  • [ 3119-15-1 ]
  • 3-[6-[(chloroacetyl)amino]-i-oxohexyl]amino-2,4,6-triiodobenzoic acid [ No CAS ]
  • [ 175732-26-0 ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; In water; 2,4-dichlorophenoxyacetic acid dimethylamine; A 3-[6-[(chloroacetyl)amino]-1-oxohexyl]amino-2,4,6-triiodobenzoic acid To 207.6 g of 6-[(chloroacetyl)amino]hexanoic acid (prepared according to the procedure described in J. Chromatography 1984, 292, 369-382) (1.00 mol), 305.4 g of thionyl chloride (2.57 mol) are slowly added and the reaction mixture heated at 60 C. After 3 h, the thionyl chloride in excess is removed. The residue is dropwise added to a suspension of 360.7 g of <strong>[3119-15-1]3-amino-2,4,6-triiodobenzoic acid</strong> (Beil. XIV, 414) (0.70 mol) in 600 ml of DMA, and leaving the temperature to rise up to 55 C. The temperature is adjusted to 60 C. and maintained for 2 h. The resulting solution is poured in 6 l of H2 O and ice obtaining a precipitate which is filtered. The residue is dissolved in 2 l of methyl ethyl ketone, the solution is concentrated, and after germination, the desired product precipitates. 212.3 g of 3-[6-[(chloroacetyl)amino]-i-oxohexyl]amino-2,4,6-triiodobenzoic acid (0.30 mol) are obtained.
 

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