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Chemical Structure| 61485-11-8 Chemical Structure| 61485-11-8

Structure of 61485-11-8

Chemical Structure| 61485-11-8

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Product Details of [ 61485-11-8 ]

CAS No. :61485-11-8
Formula : C11H15NO
M.W : 177.25
SMILES Code : CCCCC(C1=CC=CC=C1N)=O

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Application In Synthesis of [ 61485-11-8 ]

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  • Downstream synthetic route of [ 61485-11-8 ]

[ 61485-11-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 61485-11-8 ]
  • [ 150374-99-5 ]
  • 4-(N-(2-pentanoylphenyl)sulfamoyl)phenyl pivalate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; at 20℃; for 4h; General procedure: Initially, phenol (10 mmol) was dissolved in acetonitrile. Themixture solution was slowly added 3,3-dimethylbutyryl chloride(1.5 equiv) at 0 C, and then stirred at room temperature for 12 h.The solvent was evaporated at reduced pressure. The residue waspurified by silica gel column chromatography using a mixture ofn-hexane and acetone to afford the phenyl pivalate. Subsequently,phenyl pivalate was dissolved in acetonitrile. The mixture solutionwas slowly added chlorosulfonic acid (1.5 equiv) at 0 C andreacted at 0 C for 15 min, and then refluxed at 75 C for 2 h. Thesolutions were quenched by ice; the resulting mixtures were filtrated;and the residues was purified by silica gel column chromatographyusing a mixture of n-hexane/ethyl acetate to afford<strong>[150374-99-5]4-(chlorosulfonyl)phenyl pivalate</strong> (Scheme 1). To a mixture solutionof 2-aminoacetophenone, 1-(2-aminophenyl)propan-1-one,1-(2-aminophenyl)butan-1-one, 1-(2-aminophenyl)pentan-1-one,or 2-aminobenzaldehyde (each 1.0 equiv) in pyridine, respectively,was added <strong>[150374-99-5]4-(chlorosulfonyl)phenyl pivalate</strong>, and then stirred atroom temperature for 4 h. The reaction mixture was concentratedand purified by silica gel column chromatography using a mixtureof n-hexane/acetone solutions, to afford the products (Scheme 2,1-5).
 

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