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Chemical Structure| 61550-02-5 Chemical Structure| 61550-02-5

Structure of 61550-02-5

Chemical Structure| 61550-02-5

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Product Details of [ 61550-02-5 ]

CAS No. :61550-02-5
Formula : C7H12O2Si
M.W : 156.25
SMILES Code : C[Si](OC1=CC=CO1)(C)C
MDL No. :MFCD00011729
InChI Key :ILBCDLOQMRDXLN-UHFFFAOYSA-N
Pubchem ID :188414

Safety of [ 61550-02-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P210-P261-P305+P351+P338
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 61550-02-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 61550-02-5 ]

[ 61550-02-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 61550-02-5 ]
  • [ 6374-91-0 ]
  • 5,7-dibromo-3-hydroxy-3-(5-oxo-2,5-dihydrofuran-2-yl)indolin-2-one [ No CAS ]
  • 5,7-dibromo-3-hydroxy-3-(5-oxo-2,5-dihydrofuran-2-yl)indolin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: To a solution of isatin 1 (1 mmol) in THF (2 mL) was added La(OTf)3 (5 mol %). The mixture was cooled to -78 C and stirred at this temperature for 15 min. Then the solution of 2-(trimethylsilyloxy)furan 2 (1.5 mmol) in THF (1 mL) was added dropwise. The mixture was stirred at -78 C for 2 h. Later the mixture was brought to 20 C and stirred for additional 0.5-1.5 h (Table 1). The reaction was monitored by TLC. After the completion of the reaction it was diluted with tetrahydrofuran (2.0 mL) and quenched with 10% aqueous HCl (1.0 mL). The mixture was stirred for 0.25 h at room temperature, neutralized by the addition of a saturated aqueous NaHCO3 solution, and extracted with ethyl acetate (3×5 mL). The combined organic layer washed with brine solution, dried over Na2SO4, and concentrated under reduced pressure (rotary evaporator). The crude products were purified by silica gel column chromatography (ethyl acetate/hexanes). The inseparable diastereomers threo/erythro ratio of the product was determined by 1H NMR analysis of the crude reaction mixture.
 

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