616-83-1|4-Methyl-3-nitrobenzene-1-sulfonyl chloride| Ambeed

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Structure of 616-83-1

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Quality Control of [ 616-83-1 ] Purity: 98% SDS Specification

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Product Details of [ 616-83-1 ]

CAS No. :	616-83-1
Formula :	C₇H₆ClNO₄S
M.W :	235.64
SMILES Code :	O=S(C1=CC=C(C)C([N+]([O-])=O)=C1)(Cl)=O
MDL No. :	MFCD00129811
InChI Key :	OQFYBGANSUNUAO-UHFFFAOYSA-N
Pubchem ID :	560638

Safety of [ 616-83-1 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H314
Precautionary Statements:	P280-P305+P351+P338-P310
Class:	8
UN#:	3265
Packing Group:	Ⅱ

Application In Synthesis of [ 616-83-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 616-83-1 ]

[ 616-83-1 ] Synthesis Path-Downstream 1~1

1
[ 616-83-1 ]
[ 932-32-1 ]
[ 1303573-46-7 ]

Yield	Reaction Conditions	Operation in experiment
47%	With pyridine; dmap; In dichloromethane; at 0 - 20℃;	General procedure: To a solution of the appropriate aniline in dry CH2Cl2 (10 mL for 3 mmol of aniline), pyridine (1.5 eq) and catalytic DMAP (15 mg) were added, then the resulting mixture was cooled to 0 C. Subsequently, commercially available sulfonylchloride 6 (1.2 eq) in dry CH2Cl2 (10 mL for 3.6 mmol of benzenesulfonylchloride) was added dropwise and the reaction was kept under stirring at RT overnight. The reaction mixture was acidified with 1N aqueous HCl, extracted several times with CH2Cl2 and the combined organic phase was dried over anhydrous sodium sulphate. Evaporation under vacuum of the organic solvent afforded a crude product which was purified by column chromatography over silica gel, to yield the sulfonamidic derivative.

References: [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 7331 - 7336.

Historical Records

Technical Information

• Alkyl Halide Occurrence • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

Related Functional Groups of
[ 616-83-1 ]

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Precautionary Statements-General
Code	Phrase
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Prevention
Code	Phrase
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Disposal
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
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H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
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H242	Heating may cause a fire
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H261	In contact with water releases flammable gas
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H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
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H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
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H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
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H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 616-83-1

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