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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 617-92-5 Chemical Structure| 617-92-5

Structure of 617-92-5

Chemical Structure| 617-92-5

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4.5 *For Research Use Only !

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Product Citations

Product Citations

Gong, Ningqiang ; Kim, Dongyoon ; Alameh, Mohamad-Gabriel ; El-Mayta, Rakan ; Han, Emily L ; Dwivedi, Garima , et al.

Abstract: The immunogenicity of lipid nanoparticles (LNPs) used for the delivery of nucleoside-modifed messenger RNA limits the levels and durability of expression of the encoded protein. Here, by leveraging the Mannich reaction for ionizable lipid synthesis, and via the in vitro and in vivo screening of six combinatorial libraries of synthesized lipids, we report the identifcation of an antioxidant ionizable lipid, C-a16, exhibiting reduced immunogenicity. When incorporated into LNPs for mRNA delivery, C-a16 mitigated the generation of intracellular reactive oxygen species, thereby extending the duration of protein expression. In mice, and compared with commercial LNPs, LNPs incorporating C-a16 and co-delivering Cas9 mRNA and guide RNA for the editing of the transthyretin gene led to 2.8-fold higher editing efciency; LNPs with C-a16 delivering fbroblast growth factor 21 mRNA increased the expression of the protein 3.6-fold; and when delivering mRNA encoding a tumour neoantigen or the spike protein of SARS-CoV-2, LNPs with C-a16 induced stronger antigen-specifc immune responses. Our fndings support the further testing of C-a16 as a promising ionizable lipid for mRNA delivery in therapeutic applications.

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Product Details of [ 617-92-5 ]

CAS No. :617-92-5
Formula : C6H9N
M.W : 95.14
SMILES Code : CCN1C=CC=C1
MDL No. :MFCD00060633

Safety of [ 617-92-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P210-P233-P240-P241-P242-P243-P260-P261-P264-P271-P280-P302+P352-P303+P361+P353-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P370+P378-P403-P403+P233-P403+P235-P405-P501
Class:3
UN#:1993
Packing Group:
 

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