Home Cart Sign in  
Chemical Structure| 50966-65-9 Chemical Structure| 50966-65-9

Structure of 50966-65-9

Chemical Structure| 50966-65-9

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Gong, Ningqiang ; Kim, Dongyoon ; Alameh, Mohamad-Gabriel ; El-Mayta, Rakan ; Han, Emily L ; Dwivedi, Garima , et al.

Abstract: The immunogenicity of lipid nanoparticles (LNPs) used for the delivery of nucleoside-modifed messenger RNA limits the levels and durability of expression of the encoded protein. Here, by leveraging the Mannich reaction for ionizable lipid synthesis, and via the in vitro and in vivo screening of six combinatorial libraries of synthesized lipids, we report the identifcation of an antioxidant ionizable lipid, C-a16, exhibiting reduced immunogenicity. When incorporated into LNPs for mRNA delivery, C-a16 mitigated the generation of intracellular reactive oxygen species, thereby extending the duration of protein expression. In mice, and compared with commercial LNPs, LNPs incorporating C-a16 and co-delivering Cas9 mRNA and guide RNA for the editing of the transthyretin gene led to 2.8-fold higher editing efciency; LNPs with C-a16 delivering fbroblast growth factor 21 mRNA increased the expression of the protein 3.6-fold; and when delivering mRNA encoding a tumour neoantigen or the spike protein of SARS-CoV-2, LNPs with C-a16 induced stronger antigen-specifc immune responses. Our fndings support the further testing of C-a16 as a promising ionizable lipid for mRNA delivery in therapeutic applications.

Purchased from AmBeed: ; ;

Alternative Products

Product Details of [ 50966-65-9 ]

CAS No. :50966-65-9
Formula : C12H21N
M.W : 179.30
SMILES Code : CCCCCCCCN1C=CC=C1
MDL No. :MFCD00191473
InChI Key :AXCMRJJCPRARIT-UHFFFAOYSA-N
Pubchem ID :10631204

Safety of [ 50966-65-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
 

Historical Records

Technical Information

Categories