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Chemical Structure| 620-24-6 Chemical Structure| 620-24-6
Chemical Structure| 620-24-6

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KSD 2405 is an endogenous metabolite.

4.5 *For Research Use Only !

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Product Citations

Product Citations

Nenadovich, Milica ; Kubal, Molly ; Hopp, Maci R ; Crawford, Abigail D ; Hardewig, Megan E ; Sedlock, Madison G , et al.

Abstract: The increasing prevalence of antibiotic resistance and the limited availability of therapeutics for pathogens such as human respiratory syncytial virus (hRSV) underscore the need for novel, plant-derived antimicrobial substances. In this study, we evaluated the antiproliferative, , and activities of aqueous leaf extracts from two plants commonly found in North America, Osage orange (M. pomifera) and spearmint (M. spicata). Both extracts exhibited no significant cytotoxic or morphologic impact on HEp-2 human cancer cells up to 25 mg/mL. However, both extracts demonstrated strong dose-dependent activity, significantly inhibiting replication of E. coli and S. aureus at concentrations ≥ 1 mg/mL. assays revealed that both extracts inhibited hRSV infectivity, with spearmint extract showing higher potency (EC50 = 1.01 mg/mL) compared to Osage orange (EC50 = 3.85 mg/mL). Gas chromatography–mass spectrometry (GC-MS) identified three major extract constituents: 3-hydroxybenzyl alcohol, (Osage orange), and R-(-)-carvone (spearmint). Among these, only significantly inhibited hRSV in vitro, suggesting its key role in spearmint’s activity. These findings highlight the therapeutic potential of Osage orange and spearmint leaf extracts, particularly as sources of water-soluble compounds with antimicrobial properties, and support further investigation into their mechanisms of action and broader clinical relevance.

Keywords: ; cancer ; phytochemistry ; respiratory syncytial virus ; antibacterial

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Product Details of KSD 2405

CAS No. :620-24-6
Formula : C7H8O2
M.W : 124.13
SMILES Code : OCC1=CC=CC(O)=C1
MDL No. :MFCD00004643
InChI Key :OKVJCVWFVRATSG-UHFFFAOYSA-N
Pubchem ID :102

Safety of KSD 2405

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of KSD 2405

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 620-24-6 ]
  • Downstream synthetic route of [ 620-24-6 ]

[ 620-24-6 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 620-24-6 ]
  • [ 2737-19-1 ]
  • [ 2316-63-4 ]
References: [1] Phytochemistry, 1994, vol. 37, # 2, p. 307 - 310.
 

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