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Chemical Structure| 620604-73-1 Chemical Structure| 620604-73-1

Structure of 620604-73-1

Chemical Structure| 620604-73-1

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Product Details of [ 620604-73-1 ]

CAS No. :620604-73-1
Formula : C10H12N2O
M.W : 176.22
SMILES Code : N#CCC1=CC(OC)=C(N)C=C1C
MDL No. :MFCD20723788

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Application In Synthesis of [ 620604-73-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 620604-73-1 ]

[ 620604-73-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 620604-73-1 ]
  • [ 1197953-49-3 ]
  • C22H23ClN5O2P [ No CAS ]
YieldReaction ConditionsOperation in experiment
33.4% With hydrogenchloride; In 2-methoxy-ethanol; isopropyl alcohol; at 120℃;Inert atmosphere; 50mL with magnetic stirring and condenserCompound 35 (1.4 g, 7.9 mmol) was added to a single-mouth bottle.Compound 7 (2.5 g, 7.9 mmol) and ethylene glycol monomethyl ether (15 mL),Stir and dissolve,Adding hydrogen chloride in isopropanol solution(11.8mmol, 2.4mL, 5M),The temperature was raised to 120 C under a nitrogen atmosphere and stirred to react overnight. Cool to room temperature,Add water (30 mL) and saturated sodium bicarbonate (30 mL).Extracted with dichloromethane (40 mL x 3),Combine the organic phase,Washed with saturated saline,Dry without water sodium sulfate,filter,concentrate,The residue was passed through a silica gel column to give a white solid.The yield was 33.4%.
 

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