There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 624-48-6 | MDL No. : | MFCD00008459 |
Formula : | C6H8O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | LDCRTTXIJACKKU-ARJAWSKDSA-N |
M.W : | 144.13 | Pubchem ID : | 5271565 |
Synonyms : |
|
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P260-P264-P270-P271-P272-P273-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312-P305+P351+P338-P314-P333+P313-P337+P313-P403+P233-P405-P501 | UN#: | 2810 |
Hazard Statements: | H302-H311-H317-H319-H335-H373-H401 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With thionyl chloride; In toluene; | EXAMPLE V This example further illustrates the preparation of an aminomulticarboxylate acid reagent, i.e., 2-chloroethyl, N-methylaminosuccinic acid. A 250 ml 3-neck round bottom flask fitted with a water cooled condenser, mechanical stirrer and addition funnel was charged with 64 ml (0.80 mole) of N-methylaminoethanol. Dimethyl maleate (100 ml, 0.80 mole) was added slowly over about 30 minutes with agitation. The reaction was warmed to 45C and stirred for 18 hours. When the reaction was complete, the product was transferred with 75 ml of toluene to a 1,000 ml 4-neck round bottom flask equipped with addition funnel, mechanical stirrer, oil bath and distillation head. The addition funnel was charged with 25.5 ml of thionyl chloride and added to the reaction slowly to keep the temperature at or below 35C. After addition, the reaction was heated to 80C for 30 minutes. The toluene was steam distilled until the head temperature reached 98 to 100C for three minutes. The product was cooled and filtered and then analyzed and gave acceptable chlorine and NMR values, indicating the desired compound, i.e., 2-chloroethyl, N-methylaminosuccinic acid, had been prepared. | |
With thionyl chloride; In toluene; | EXAMPLE 6 Preparation of an Aminomulti-carboxylate Acid Reagent, i.e., 2-chloroethyl, N-methylaminosuccinic Acid. A 250 ml 3-neck round bottom flask fitted with a water cooled condenser, mechanical stirrer and addition funnel was charged with 60 g (0.80 mole) of N-methylaminoethanol. Dimethyl maleate (115.3 g, 0.80 mole) was added slowly over about 30 minutes with agitation. The reaction was warmed to 45 C. and stirred for 18 hours. When the reaction was complete, the product was transferred with 75 ml of toluene to a 1,000 ml 4-neck round bottom flask equipped with addition funnel, mechanical stirrer, oil bath and distillation head. The addition funnel was charge with 110 ml of thionyl chloride and added to the reaction slowly to keep the temperature at or below 35 C.. After addition, the reaction was heated to 80 C. for 30 minutes. The toluene was steam distilled until the head temperature reached 98 to 100 C. for three minutes. The product was cooled and filtered and then analyzed and gave acceptable chlorine and NMR values, indicating the desired compound, i.e., 2-chloroethyl, N-methylaminosuccinic acid, had been prepared. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | With C42H28O9P2 In chloroform at 50℃; Molecular sieve; optical yield given as %ee; enantioselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
13% | In neat (no solvent); for 5h;Reflux; | General procedure: To a neat of 11a-o (1.0 equiv) was added dropwise dimethyl maleate (2.0 equiv). The mixture was refluxed for 5 h with stirring and cooled to room temperature. The mixture was diluted using ethanol and saturated with HCl gas and concentrated in vacuum. Water was added to the mixture and mixture was extracted with dichloromethane three times. The organic layers were combined and dried with anhydrous Na2SO4. After Na2SO4 was filtered, solvent was removed in vacuum and the residue was purified by silica gel column chromatography with hexanes: ethyl acetate=7:1 to afford 12a-o as sticky oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
17.2% | In neat (no solvent); for 5h;Reflux; | General procedure: To a neat of 11a-o (1.0 equiv) was added dropwise dimethyl maleate (2.0 equiv). The mixture was refluxed for 5 h with stirring and cooled to room temperature. The mixture was diluted using ethanol and saturated with HCl gas and concentrated in vacuum. Water was added to the mixture and mixture was extracted with dichloromethane three times. The organic layers were combined and dried with anhydrous Na2SO4. After Na2SO4 was filtered, solvent was removed in vacuum and the residue was purified by silica gel column chromatography with hexanes: ethyl acetate=7:1 to afford 12a-o as sticky oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With copper(II) acetate monohydrate; triphenylphosphine; In dichloromethane; at -5℃;Inert atmosphere; Schlenk technique; Molecular sieve; | (2R,3R,4S,5S)-2-ethyl 3,4-dimethyl phenylpyrrolidine-2,3,4-tricarboxylate (4nc) Ligh yellow oil: Yield = 65%; ee = 92.4%; 1H NMR (500 MHz, CDCl3) δ 7.45 (d, J = 7.3 Hz, 2H), 7.31 (t, J = 7.5 Hz, 2H), 7.25 (d, J = 7.3 Hz, 1H), 4.66 (s, 1H), 4.34 (d, J = 1.9 Hz, 1H), 4.24 (qd, J = 7.1, 2.8 Hz, 2H), 3.70 (s, 3H), 3.63 (s, 3H), 3.62-3.58 (m, 1H), 3.24 (t, J = 8.3 Hz, 1H), 2.78 (br, 1H), 1.30 (t, J = 7.1 Hz, 3H). 13C NMR (126 MHz, CDCl3) δ 172.48, 171.61, 141.31, 128.52, 127.76, 126.96, 64.51, 62.01, 61.53, 54.33, 52.38, 52.09, 49.92, 14.16. (KBr) υ 2982, 1732, 1440, 1370, 1265, 1170, 910, 715 cm-1. HRMS Calcd. For C17H22NO6+ [M+H]+:336.1444; found: 336.1428. HPLC (Chiralpak AD-H column, hexane/2-propanol = 90/10, flow rate = 1 mL/min) tR = 11.90 min, 19.93 min. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | With siloxane-FOXAP; copper(II) acetate monohydrate; triethylamine; In dichloromethane; at -5℃;Inert atmosphere; Schlenk technique; Molecular sieve; | (2R,3R,4S,5S)-2-ethyl 3,4-dimethyl phenylpyrrolidine-2,3,4-tricarboxylate (4nc) Ligh yellow oil: Yield = 65%; ee = 92.4%; 1H NMR (500 MHz, CDCl3) δ 7.45 (d, J = 7.3 Hz, 2H), 7.31 (t, J = 7.5 Hz, 2H), 7.25 (d, J = 7.3 Hz, 1H), 4.66 (s, 1H), 4.34 (d, J = 1.9 Hz, 1H), 4.24 (qd, J = 7.1, 2.8 Hz, 2H), 3.70 (s, 3H), 3.63 (s, 3H), 3.62-3.58 (m, 1H), 3.24 (t, J = 8.3 Hz, 1H), 2.78 (br, 1H), 1.30 (t, J = 7.1 Hz, 3H). 13C NMR (126 MHz, CDCl3) δ 172.48, 171.61, 141.31, 128.52, 127.76, 126.96, 64.51, 62.01, 61.53, 54.33, 52.38, 52.09, 49.92, 14.16. (KBr) υ 2982, 1732, 1440, 1370, 1265, 1170, 910, 715 cm-1. HRMS Calcd. For C17H22NO6+ [M+H]+:336.1444; found: 336.1428. HPLC (Chiralpak AD-H column, hexane/2-propanol = 90/10, flow rate = 1 mL/min) tR = 11.90 min, 19.93 min. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | With tributylphosphine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0℃; | Dissolve 9.74 g (48.2 mmol) tributylphosphine and 0.49 g (3.2 mmol) of 1,8-diazabicyclo-carbon-7-ene in 10 mL of dry dichloromethane (MC) And the solution was slowly injected at 0 C into 40 mL of dry MC in which 4.5 g (32.1 mmol) of 2,3-thiophenedialdehyde and 4.86 g (33.7 mmol) of dimethyl maleate were dissolved. . The product from this was separated and purified by silica gel column chromatography (elution solvent: MC) to obtain 5.2 g of dimethyl benzo[b]thiophene-5,6-dicarboxylate (65% yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
46% | Stage #1: 4,5-dimethoxyphthalic anhydride; dimethyl cis-but-2-ene-1,4-dioate With chloro-trimethyl-silane; triethylamine at 20℃; Electrochemical reaction; Stage #2: With hydrogenchloride at 20℃; for 0.5h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With iron(III) chloride; choline chloride; toluene-4-sulfonic acid at 60 - 70℃; for 6h; | 6 Example 6: Synthesis of dimethyl maleate In a 250mL three-necked flask, add p-toluenesulfonic acid (19g, 0.1mol), choline chloride (7g, 0.05mol), ferric chloride (0.081g, 0.5mmol) and stir for 30min at 70 until the system becomes Colorless and transparent liquid to obtain a deep eutectic solvent, then add anhydrous methanol (40.5mL, 1.6mol), maleic acid (11.6g, 0.1mol), heat and reflux at 60 for 6h, the reaction is over, and the reaction is completed under normal pressure. Excess methanol is removed and recovered, and then extracted with methyl tert-butyl ether. The lower deep eutectic solvent layer can be used for the next cycle after being vacuum dried. The upper organic layer is first distilled under normal pressure to distill methyl tert-butyl ether and recovered. Then vacuum distillation (-100kpa) collects the 85°C fraction to obtain the product, dimethyl maleate. The yield is 90%, and the remaining undistilled liquid is monomethyl maleate and a small amount of maleic acid. , Put it into the deep eutectic solvent to continue the reaction, and repeat the above-mentioned post-treatment process, the yield of the deep eutectic solvent is still more than 90% after the deep eutectic solvent is recycled for 10 times. |
Tags: 624-48-6 synthesis path| 624-48-6 SDS| 624-48-6 COA| 624-48-6 purity| 624-48-6 application| 624-48-6 NMR| 624-48-6 COA| 624-48-6 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :