Alternatived Products of [ 62438-03-3 ]
Product Details of [ 62438-03-3 ]
| CAS No. : | 62438-03-3 |
MDL No. : | MFCD02091279 |
| Formula : |
C5H7N3O2
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
141.13
|
Pubchem ID : | - |
| Synonyms : |
|
Application In Synthesis of [ 62438-03-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 62438-03-3 ]
- 1
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[ 19788-35-3 ]
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[ 62438-03-3 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With hydrazine hydrate |
|
- 2
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[ 62438-03-3 ]
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[ 619-22-7 ]
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[ 93569-42-7 ]
- 3
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[ 62438-03-3 ]
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[ 621-63-6 ]
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[ 89853-92-9 ]
- 4
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[ 3209-72-1 ]
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[ 62438-03-3 ]
| Yield | Reaction Conditions | Operation in experiment |
| 82% |
With hydrazine hydrate In ethanol for 6h; Heating; |
|
| 75% |
With hydrazine hydrate In ethanol for 24h; Reflux; |
23 Preparation of 5-methyl-isoxazole-3-carboxylic acid hydrazide
5-Methyl-isoxazole-3-carboxylic acid ethyl ester (3.lg,20) was dissolved in 3011 ethanol and 80% hydrazine hydrate was added. The reaction mixture was heated to reflux 2411 and cooled to precipitate a white solid which was filtered off and dried to give a white solid. 75%. |
| 29% |
With hydrazine hydrate In methanol |
1.c c
c 5-Methylisoxazole-3-carboxylic Acid Hydrazide To a solution of ethyl 5-methylisoxazole-3-carboxylate (3.0 g, 19 mmol) in methanol (30 ml) at 0° C. under nitrogen was added hydrazine hydrate (3.04 g, 95 mmol) over 0.3 h. The reaction was stirred at 0° C. for 0.25 h and at RT for 1 h. The white precipitate was filtered off and washed with methanol to give the title-compound (0.78 g, 29%) as a white solid, 1H NMR (250 MHz, CDCl3) δ 2.41 (3H, d, J=0.8 Hz, CH3), 4.07 (2H, br s, NH2), 6.44 (1H, q, J=0.8 Hz, Ar-H), 7.99 (1H, br s, N-H); MS (ES+) m/e 142 [MH]+. |
|
With hydrazine hydrate In water; isopropyl alcohol |
|
Reference：
[1]Sung; Lee
[Journal of Heterocyclic Chemistry, 1992, vol. 29, # 5, p. 1101 - 1109]
[2]Current Patent Assignee: PEKING UNIVERSITY - CN106146487, 2016, A
Location in patent: Paragraph 0215; 0216; 0217
[3]Current Patent Assignee: MERCK & CO INC - US6613766, 2003, B1
[4]Gardner,T.S. et al.
[Journal of Organic Chemistry, 1961, vol. 26, p. 1514 - 1518]
- 5
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[ 62438-03-3 ]
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[ 59-63-2 ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: ethanol
2: KBH4 / methanol; H2O |
|
- 6
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[ 590-92-1 ]
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[ 62438-03-3 ]
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2-bromoethyl-5-[3-(5-methylisoxazolyl)]-1,3,4-oxadiazole
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
With trichlorophosphate; In toluene; at 100℃; for 2h; |
General procedure: A mixture of benzoylhydrazine 23 (0.68 g, 5 mmol), 3-<strong>[590-92-1]bromopropionic acid</strong> (1.2 g, 7.5 mmol), POCl3 (4 mL) in toluene (20 mL) was stirred at 100 C for 2 h. After cooling to room temperature, the mixture was poured into ice water slowly, and extracted with ethyl acetate (20 mL* 3). The organic layer was combined, dried over Na2SO4, and concentrated to afford crude 2-(2-bromoethyl)-5-phenyl-1,3,4- oxadiazole 19o as a yellow solid in 41% of yield. This crude product was used without purification. Following the same procedure for the synthesis of 17a, targetcompound 17o was obtained using crude 2-(2-bromoethyl)-5-phenyl-1,3,4-oxadiazole 19o as halide. |
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